Protein Alignment Pkc53E and aPKC

DIOPT Version :10

• Sequence 1: NP_725626.1
• Gene: Pkc53E / 48311
• FlyBaseID: FBgn0003091
• Length: 679
• Species: Drosophila melanogaster
• Sequence 2: XP_061518621.1
• Gene: aPKC / 1280683
• VectorBaseID: AGAMI1_009490
• Length: 826
• Species: Anopheles gambiae
• Alignment Length: 676
• Identity: 225/676 - (33%)
• Similarity: 304/676 - (44%)
• Gaps: 199/676 - (29%)

  Fly    11 PQQQGAEG-EAVGENKMKSRLRKGALKKKNVFNVKDHCFIARFFKQPTFCSHCKDFICGYQSGYA 74
            |....|.| ..|||:  :|..|:||.:.:.::.:..|.|.|:.|.:..||:.|.|.|
Mosquito   328 PNVPSAPGLSCVGED--RSIYRRGARRWRKLYRINGHIFQAKRFNRKAFCAFCHDRI-------- 382

  Fly    75 WMGFGKQGFQCQVCSYVVHKRCHEYVTFICPGKDKGIDSDSPKTQHNFEPFTYAGPTFCDHCGSL 139
            | |.|:|||:|..|..:|||:||:.
Mosquito   383 W-GLGRQGFKCIQCKLLVHKKCHKL---------------------------------------- 406

  Fly   140 LYGIYHQGLKCSACDMNVHARCKENVPSLCGCDHTERRGRIYLEINVKENLLTVQIKEGRNLIPM 204
                                   .|.|  |..:|.|
Mosquito   407 -----------------------GNKP--CSNEHVE----------------------------- 417

  Fly   205 DPNGLSDPYVKVKLIPDDKDQSKKKTRTIKACLNPVWNETLTYDLKPEDKDRRILIEVWDWDRTS 269
                                              ||:.|...:|  |.|:.
Mosquito   418 ----------------------------------PVFKERDHHD--PNDES-------------- 432

  Fly   270 RNDFMGALSFGISEIIKNPTNGWFKLLTQDEGEYYNVPCADDEQDLLKLKQKPSQKKPMVMRSDT 334
                      ...::|:.|.:...:|.:.|..:...|...|:.::.|         :|:..|
Mosquito   433 ----------STGDVIQAPLDYPSELHSGDGCDQVPVEVNDNVEETL---------EPVTQR--- 475

  Fly   335 NTHTSSKKDMIRATDFNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEK 399
                     .....||..|:|:|:||:.|||:.|.|.:..:||:|::||.::..|:|::....||
Mosquito   476 ---------QYSLNDFELIRVIGRGSYAKVLMVELKKTRRIYAMKVIKKALVTDDEDIDWVQTEK 531

  Fly   400 RVLALGEKPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGLFF 464
            .|.......||||.|||||||..|||||:|:|.||||||.:|:..:..|..|.||||||:..|.|
Mosquito   532 HVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMFHMQRQRRLPEEHARFYAAEISLALNF 596

  Fly   465 LHTKGILYRDLKLDNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQPYGKS 529
            ||.|||:||||||||||||.:||:|:.|:|||||.|....||.||||||:||||||:..:.||.|
Mosquito   597 LHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFS 661

  Fly   530 VDWWAYGVLLYEMLVGQPPF---------DGEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLT 585
            |||||.||||||||.|:.||         |...|:.||..|.:..:..|:|||.:|....||||.
Mosquito   662 VDWWALGVLLYEMLAGRSPFDIAGASENPDQNTEDYLFQVILEKTIRIPRSLSVKAASVLKGFLN 726

  Fly   586 KQPNKRLGCG-SSGEEDVRLHPFFRRIDWEKIENREVQPPFKPKIKH-RKDVS-NFDKQFTSEKT 647
            |.|..||||. .|...|:..|.||:.||||.:..:||.||:.|.... .:|:: :||.|||.|..
Mosquito   727 KNPADRLGCNRDSAFLDIMNHSFFKSIDWEMLAQKEVTPPYIPSFDGCDQDITCHFDPQFTREPA 791

  Fly   648 DLTPTDKVFMMNLDQSEFVGFSYMNP 673
            ||||.|...:..:|||||.||.|:||
Mosquito   792 DLTPDDPRVIDKIDQSEFEGFEYVNP 817

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383	22/65 (34%)
		C1_cPKC_rpt2	120..173	CDD:410386	3/52 (6%)
		C2_PKC_alpha_gamma	177..307	CDD:175992	10/129 (8%)
		STKc_cPKC	353..672	CDD:270739	169/330 (51%)
aPKC	XP_061518621.1	None