DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc53E and RSKR

DIOPT Version :9

Sequence 1:	NP_725626.1	Gene:	Pkc53E / 48311	FlyBaseID:	FBgn0003091	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	NP_001167574.1	Gene:	RSKR / 124923	HGNCID:	26314	Length:	410	Species:	Homo sapiens

Alignment Length:	308	Identity:	92/308 - (29%)
Similarity:	151/308 - (49%)	Gaps:	36/308 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   353 IKVLG---KGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDV-EC---TMIEKRVLALGEKPPF 410
            :|:||   |||||.||.......:.::|:|::.|..::|.|.| :|   ..|::::     ..||
Human   107 LKILGLVAKGSFGTVLKVLDCTQKAVFAVKVVPKVKVLQRDTVRQCKEEVSIQRQI-----NHPF 166

  Fly   411 LVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGLFFLHTKGILYRDL 475
            :..|...:|....||.:..|.: .||.......|.|.|.....:|||:...|.:||..||::||:
Human   167 VHSLGDSWQGKRHLFIMCSYCS-TDLYSLWSAVGCFPEASIRLFAAELVLVLCYLHDLGIMHRDV 230

  Fly   476 KLDNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLY 540
            |::|:|||..||:|:.|||:.: ::.......|.|||..|:|||::...||..:.|||:.||||:
Human   231 KMENILLDERGHLKLTDFGLSR-HVPQGAQAYTICGTLQYMAPEVLSGGPYNHAADWWSLGVLLF 294

  Fly   541 EMLVGQPPFDGE-DEEELFAAITDHNVSYPKSLSKEAKEACKGFLTKQPNKRLGCGSSGEEDVRL 604
            .:..|:.|...| |...:.|::|..:...|.||::.........|.:.|..||    ......::
Human   295 SLATGKFPVAAERDHVAMLASVTHSDSEIPASLNQGLSLLLHELLCQNPLHRL----RYLHHFQV 355

  Fly   605 HPFFRRIDWEKIENREVQPPFKPKIKHRKDVSNFDKQFTSEKTDLTPT 652
            |||||.:            .|.|::..::.|:     |.:|.....|:
Human   356 HPFFRGV------------AFDPELLQKQPVN-----FVTETQATQPS 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383
		C1_cPKC_rpt2	120..173	CDD:410386
		C2_PKC_alpha_gamma	177..307	CDD:175992
		STKc_cPKC	353..672	CDD:270739	92/308 (30%)
RSKR	NP_001167574.1	S_TKc	108..324	CDD:214567	74/222 (33%)
RSKR	NP_001167574.1	STKc_AGC	115..359	CDD:270693	80/254 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910