DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pkc53E and Akt1

DIOPT Version :10

Sequence 1:NP_725626.1 Gene:Pkc53E / 48311 FlyBaseID:FBgn0003091 Length:679 Species:Drosophila melanogaster
Sequence 2:NP_001159366.1 Gene:Akt1 / 11651 MGIID:87986 Length:488 Species:Mus musculus


Alignment Length:434 Identity:166/434 - (38%)
Similarity:251/434 - (57%) Gaps:33/434 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly   247 YDLKPEDKDRR---------ILIEVWDWDRTSRNDF-MGALSFGISEIIKNPTNGWFKLLTQDEG 301
            |..:|:|.|:|         ...::...:|...|.| :..|.:  :.:|:..    |.:.|.:|.
Mouse    38 YKERPQDVDQRESPLNNFSVAQCQLMKTERPRPNTFIIRCLQW--TTVIERT----FHVETPEER 96

  Fly   302 EYYNVPCADDEQDLLKLKQKPSQKKPMVMRSDTNTHTSSKKDM----------IRATDFNFIKVL 356
            |.:..........|     |..:::.|..||.:.:..|..::|          :...:|.::|:|
Mouse    97 EEWATAIQTVADGL-----KRQEEETMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLL 156

  Fly   357 GKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEKRVLALGEKPPFLVQLHSCFQTM 421
            |||:||||:|.:.|.:...||:|||||:||:..|:|..|:.|.|||. ..:.|||..|...|||.
Mouse   157 GKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ-NSRHPFLTALKYSFQTH 220

  Fly   422 DRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGLFFLHT-KGILYRDLKLDNVLLDAD 485
            |||.|||||.|||:|.|.:.:...|.|..|.||.|||.:.|.:||: |.::||||||:|::||.|
Mouse   221 DRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKD 285

  Fly   486 GHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLYEMLVGQPPFD 550
            ||:||.|||:|||.|....|.|||||||:|:|||::....||::||||..||::|||:.|:.||.
Mouse   286 GHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFY 350

  Fly   551 GEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTKQPNKRLGCGSSGEEDVRLHPFFRRIDWEK 615
            .:|.|:||..|....:.:|::|..|||....|.|.|.|.:|||.||...:::..|.||..|.|:.
Mouse   351 NQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPTQRLGGGSEDAKEIMQHRFFANIVWQD 415

  Fly   616 IENREVQPPFKPKIKHRKDVSNFDKQFTSEKTDLTPTDKVFMMN 659
            :..:::.|||||::....|...||::||::...:||.|:|.:::
Mouse   416 VYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQVLLLS 459

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pkc53ENP_725626.1 C1_cPKC_rpt1 44..110 CDD:410383
C1_cPKC_rpt2 120..173 CDD:410386
C2_PKC_alpha_gamma 177..307 CDD:175992 14/69 (20%)
STKc_cPKC 353..672 CDD:270739 144/308 (47%)
Akt1NP_001159366.1 PH_PKB 4..111 CDD:269947 15/83 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 114..137 5/22 (23%)
STKc_PKB 154..466 CDD:270723 144/307 (47%)
Blue background indicates that the domain is not in the aligned region.

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