Protein Alignment Pkc53E and C8orf44-SGK3

DIOPT Version :10

• Sequence 1: NP_725626.1
• Gene: Pkc53E / 48311
• FlyBaseID: FBgn0003091
• Length: 679
• Species: Drosophila melanogaster
• Sequence 2: NP_001191102.1
• Gene: C8orf44-SGK3 / 100533105
• HGNCID: 48354
• Length: 496
• Species: Homo sapiens
• Alignment Length: 501
• Identity: 183/501 - (36%)
• Similarity: 260/501 - (51%)
• Gaps: 69/501 - (13%)

  Fly   216 VKLIPDDKDQSKKKTRTIKACLNPV----W--------NETLTYDLKPE-------DKDRRILIE 261
            |.:...|:.:.|||..|:...|..|    |        .:.|...||.:       ...:||..:
Human    16 VSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNTLKKQFPAMALKIPAKRIFGD 80

  Fly   262 VWDWDRTSRNDFMGALSFGISEIIKN----PTNGWFKLLTQDEGEYYNVPCADDEQDLLKLKQKP 322
            .:|      .||:.....|::|.|:|    |             |.||.|   |.:..|::....
Human    81 NFD------PDFIKQRRAGLNEFIQNLVRYP-------------ELYNHP---DVRAFLQMDSPK 123

  Fly   323 SQKKPMV---MRSDTNTHTSSKKDMI--------RATDFNFIKVLGKGSFGKVLLAERKGSEELY 376
            .|..|..   .||....|::|:...:        :.|||:|:||:|||||||||||:||...:.|
Human   124 HQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFY 188

  Fly   377 AIKILKKDVIIQDDDVECTMIEKRVLALGEKPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQ 441
            |:|:|:|.:::...:.:..|.|:.||....|.||||.||..|||.::|:||:::||||:|.|.:|
Human   189 AVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQ 253

  Fly   442 QFGKFKEPVAVFYAAEIAAGLFFLHTKGILYRDLKLDNVLLDADGHVKIADFGMCKENIVGDKTT 506
            :...|.|..|.|||||||:.|.:||:..|:|||||.:|:|||:.|||.:.|||:|||.|....||
Human   254 RERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTT 318

  Fly   507 KTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLYEMLVGQPPFDGEDEEELFAAITDHNVSYPKS 571
            .||||||:|:|||:|..|||..:||||..|.:|||||.|.|||...|..|::..|....:|....
Human   319 TTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPG 383

  Fly   572 LSKEAKEACKGFLTKQPNKRLGCGSSGEED---VRLHPFFRRIDWEKIENREVQPPFKPKIKHRK 633
            :|..|....:..|.|....|||    .:||   ::.||||..:.|..:..:::.|||.|.:....
Human   384 VSLTAWSILEELLEKDRQNRLG----AKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPD 444

  Fly   634 DVSNFDKQFTSEKT--DLTPTDKVFMMNLDQSE----FVGFSYMNP 673
            |:.|||..||.|..  .:..:....::|....|    ||||||..|
Human   445 DIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383
		C1_cPKC_rpt2	120..173	CDD:410386
		C2_PKC_alpha_gamma	177..307	CDD:175992	25/113 (22%)
		STKc_cPKC	353..672	CDD:270739	144/327 (44%)
C8orf44-SGK3	NP_001191102.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		1/4 (25%)
		PX_CISK	12..120	CDD:132780	28/125 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	121..156		6/34 (18%)
		STKc_SGK3	165..490	CDD:270755	144/328 (44%)
		Nuclear localization signal. /evidence=ECO:0000250	195..205		1/9 (11%)