DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkc53E and LOC100498287

DIOPT Version :9

Sequence 1:	NP_725626.1	Gene:	Pkc53E / 48311	FlyBaseID:	FBgn0003091	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	XP_017952823.2	Gene:	LOC100498287 / 100498287	-ID:	-	Length:	340	Species:	Xenopus tropicalis

Alignment Length:	367	Identity:	115/367 - (31%)
Similarity:	174/367 - (47%)	Gaps:	45/367 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   311 DEQDLLKLKQKPSQKKPMVMRSDTNTHTSSKKDMIRATDFNFIKVLGKGSFGKVLLAERKGSEEL 375
            ||....|.:.:..:..|:.:||                 :.|.:.||:||.|||:||.....::|
Frog     7 DESAKKKSRVEGRRPPPLDIRS-----------------YKFHRKLGEGSGGKVMLASFAPKKQL 54

  Fly   376 YAIKILKKDVIIQDDDVECT----MIEKRVLALGEKPPFLVQLHSCFQTMDRLFFVMEYVNGGDL 436
            .||||:.|      ....|.    .:|..:..:..:.|||...|:.||:..:.|||:||..||.|
Frog    55 VAIKIVPK------KPNRCNYPWISMEAWLSKIARECPFLCHSHATFQSKAQAFFVLEYAGGGTL 113

  Fly   437 MFQIQQFGKFKEPVAVFYAAEIAAGLFFLHTKGILYRDLKLDNVLLDADGHVKIADFGMCKENIV 501
            ...|.:..........||.||:...|.|||:.||::||||.||:|:|.|||:||.|||:....:.
Frog   114 YRMISRKKNLPTKSIQFYTAEMVVALQFLHSNGIIHRDLKPDNILVDNDGHIKICDFGIAAAGMF 178

  Fly   502 GDKTTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLYEMLVGQPPF-DGEDEEELFAAITDHN 565
            .....:...|||.|.|||::..:.|....|||:.||::|||..|:.|| ...|..:.|..:....
Frog   179 AGWKIRGLAGTPGYRAPEMLSLEAYDAGADWWSLGVIMYEMATGRKPFAPSLDPAKEFLDMKLTK 243

  Fly   566 VSYPKSLSKEAKEACKGFLTKQPNKRLGCGSSGEEDVRLHPFFRRIDWEKIENREVQPPFKPKIK 630
            |.||..:|:|..:.....|....|.|||...    ::|.|.||..|:|.::|.|..|.||||||:
Frog   244 VDYPSHMSQEMLDLLPKLLEMDNNNRLGVNG----NIREHQFFAGINWSELEKRTTQTPFKPKIQ 304

  Fly   631 HRKDVSNFDKQFTSEKTDLTPTDKVFMMNLDQSEFVGFSYMN 672
            ....:......|.:|.:             ::::...|:|::
Frog   305 PADKLKEIKPGFCAETS-------------EENKLEDFTYVD 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383
		C1_cPKC_rpt2	120..173	CDD:410386
		C2_PKC_alpha_gamma	177..307	CDD:175992
		STKc_cPKC	353..672	CDD:270739	108/323 (33%)
LOC100498287	XP_017952823.2	PKc_like	35..326	CDD:419665	106/313 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165168470
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930