DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc53E and akt3b

DIOPT Version :9

Sequence 1:	NP_725626.1	Gene:	Pkc53E / 48311	FlyBaseID:	FBgn0003091	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	XP_001923454.3	Gene:	akt3b / 100149794	ZFINID:	ZDB-GENE-110309-3	Length:	479	Species:	Danio rerio

Alignment Length:	465	Identity:	177/465 - (38%)
Similarity:	256/465 - (55%)	Gaps:	71/465 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 KDQSKKKTRTIKACLNPVWNETL--TYDL-KPEDKDRRILIEVWDW--------DRTSRNDFMGA 276
            |.:..|....|..||.  |...:  |:.: .||::|        :|        |:.::.:..|.
Zfish    63 KTERPKPNTFIIRCLQ--WTTVIERTFHVDTPEERD--------EWVEAIQMVADKLAKQEEEGI 117

  Fly   277 LSFGISEIIKNPTNGWFKLLTQDEGEYYNVPCADDEQDLLKLKQKPSQKKPMVMRSDTNTHTSSK 341
            |...||:|                   .||    :|:::                 ||:|....:
Zfish   118 LCSPISQI-------------------ENV----NEEEM-----------------DTSTSHHKR 142

  Fly   342 KDMIRATDFNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEKRVLALGE 406
            |.|   .||:::|:||||:||||:|...|.|...||:|||||:|||..|:|..|:.|.|||. ..
Zfish   143 KTM---NDFDYLKLLGKGTFGKVILVREKASGTYYAMKILKKEVIIAKDEVAHTLTESRVLK-NT 203

  Fly   407 KPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGLFFLHTKGIL 471
            :.|||..|...|||.|||.|||||||||:|.|.:.:...|.|....||.|||.:.|.:||:..|:
Zfish   204 RHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSAKIV 268

  Fly   472 YRDLKLDNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQPYGKSVDWWAYG 536
            ||||||:|::||.|||:||.|||:|||.|....|.|||||||:|:|||::....||::||||..|
Zfish   269 YRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLG 333

  Fly   537 VLLYEMLVGQPPFDGEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTKQPNKRLGCGSSGEED 601
            |::|||:.|:.||..:|.|:||..|....:.:|::||.:||....|.|.|.||||||.|....::
Zfish   334 VVMYEMMCGRLPFYNQDHEKLFELILMEEIKFPRTLSADAKSLLSGLLIKDPNKRLGGGPDDAKE 398

  Fly   602 VRLHPFFRRIDWEKIENREVQPPFKPKIKHRKDVSNFDKQFTSEKTDLTPTDKVFMMNLDQSE-- 664
            :..|.||..:||:.:.::::.|||.|::....|...||::||::...:||.:|.....:|.::
Zfish   399 IMRHSFFTALDWQDVYDKKLVPPFMPQVSSETDTRYFDEEFTAQTITITPPEKYDEDGMDAADSE 463

  Fly   665 ----FVGFSY 670
                |..|||
Zfish   464 RRPHFPQFSY 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383
		C1_cPKC_rpt2	120..173	CDD:410386
		C2_PKC_alpha_gamma	177..307	CDD:175992	18/94 (19%)
		STKc_cPKC	353..672	CDD:270739	150/324 (46%)
akt3b	XP_001923454.3	PH_PKB	4..109	CDD:269947	12/55 (22%)
		PH	6..105	CDD:278594	11/51 (22%)
		PKc_like	132..479	CDD:304357	157/363 (43%)
		S_TKc	148..405	CDD:214567	130/257 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D614710at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920