Protein Alignment Pkc53E and lats1

DIOPT Version :10

• Sequence 1: NP_725626.1
• Gene: Pkc53E / 48311
• FlyBaseID: FBgn0003091
• Length: 679
• Species: Drosophila melanogaster
• Sequence 2: XP_017949762.1
• Gene: lats1 / 100145677
• XenbaseID: XB-GENE-959763
• Length: 1117
• Species: Xenopus tropicalis
• Alignment Length: 655
• Identity: 171/655 - (26%)
• Similarity: 271/655 - (41%)
• Gaps: 181/655 - (27%)

  Fly   101 TFICPGKDKGIDSDSPKTQHN-----FEPFTYAG--PTFCDHCGSLLYGIYHQGLKCSACDMNVH 158
            |::.|....|...:.  ..||     .|...|.|  |.:..|.......:|..|||.|
 Frog   509 TWMTPNVQPGPFQEG--VSHNTSAQLAEAPNYQGPPPPYPKHLLQQNTTVYEPGLKSS------- 564

  Fly   159 ARCKENVPSLCGCDHTERRGRIYLEINVKENLLTVQIKEGRNL----IPMDPNGLSDPYVKVKLI 219
               ||:...:..|...|      :|.|.:.   |..|.|.:.:    :|:..|
 Frog   565 ---KEDAAGVSTCTQEE------MEKNTEP---TTGITEKKQITTSPVPVRRN------------ 605

  Fly   220 PDDKDQSKKKTRTIKACLNPVWNETLTYDLKPEDKDRRILIEVWDWDRTSRNDFMGALSFGISEI 284
              .:|:.::              |:......|:                       |..|.:.:.
 Frog   606 --KRDEERR--------------ESQIQSYSPQ-----------------------AFKFFMEQH 631

  Fly   285 IKNPTNGWFKLL---TQDEGEYYNVPCADDEQDLLKLKQKPSQKKPMVMRSDTNTHTSSKKDMIR 346
            ::|......:.|   .|.|.|...|..:.:.||         |.:.|:.:.::| :...|:..:.
 Frog   632 VENILKSHHQRLHRKKQLENEMMRVGLSQEAQD---------QMRKMLCQKESN-YIRLKRAKME 686

  Fly   347 ATDFNFIKVLGKGSFGKVLLAERKGSEELYAIKIL-KKDVIIQDDDVECTMIEKRVLALGEKPPF 410
            .:.|..||.||.|:||:|.||.:..:..|||:|.| ||||::: :.|.....|:.:||..:. .:
 Frog   687 KSMFVKIKTLGIGAFGEVCLARKTDTNALYAMKTLRKKDVLLR-NQVAHVKAERDILAEADN-EW 749

  Fly   411 LVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGLFFLHTKGILYRDL 475
            :|:|:..||..|.|:|||:|:.|||:|..:.:.|.|.|.:|.||.||:...:..:|....::||:
 Frog   750 VVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGVFPEDLARFYIAELTCAVESVHKMDFIHRDI 814

  Fly   476 KLDNVLLDADGHVKIADFGMCK------------------------ENIVGDKT----------- 505
            |.||:|:|.|||:|:.|||:|.                        .|..||..
 Frog   815 KPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHLRQDSMDFSNEWGDPANCRCGDRLKPL 879

  Fly   506 ------------TKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLYEMLVGQPPFDGEDEEELF 558
                        ..:..|||:|||||::|...|.:..|||:.||:|||||||||||..:...|..
 Frog   880 EWRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILYEMLVGQPPFLAQSPVETQ 944

  Fly   559 AAI----TDHNVSYPKSLSKEAKE----ACKGFLTKQPNKRLGCGSSGEEDVRLHPFFRRIDWEK 615
            ..:    |..::.....||.||.:    .|:|     |..||  |.:|.:::::||||:.||:..
 Frog   945 MKVIKWQTTLHIPAQAKLSPEASDLIVKLCRG-----PEDRL--GKNGVDEIKVHPFFKNIDFSS 1002

  Fly   616 IENREVQPPFKPKIKHRKDVSNFDKQFTSEKTDLTPTDKVFMMNLD-----QSEFVGFSYMN--- 672
             :.|:...|:.|.|.|..|.||||           |.|...:.|.:     :::.:...|.|
 Frog  1003 -DLRQQPAPYTPTITHPTDTSNFD-----------PVDPEKLWNDEDKDGNKNDTLNGWYKNGKH 1055

  Fly   673 PEYVF 677
            ||:.|
 Frog  1056 PEHAF 1060

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383	2/8 (25%)
		C1_cPKC_rpt2	120..173	CDD:410386	15/59 (25%)
		C2_PKC_alpha_gamma	177..307	CDD:175992	17/136 (13%)
		STKc_cPKC	353..672	CDD:270739	123/379 (32%)
lats1	XP_017949762.1	UBA_LATS1	102..142	CDD:270580
		MobB_LATS1	614..689	CDD:439273	15/107 (14%)
		STKc_LATS1	688..1069	CDD:270775	128/394 (32%)