DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc53E and akt2

DIOPT Version :9

Sequence 1:	NP_725626.1	Gene:	Pkc53E / 48311	FlyBaseID:	FBgn0003091	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	NP_001116936.1	Gene:	akt2 / 100144709	XenbaseID:	XB-GENE-484168	Length:	485	Species:	Xenopus tropicalis

Alignment Length:	397	Identity:	167/397 - (42%)
Similarity:	236/397 - (59%)	Gaps:	25/397 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   293 FKLLTQDEGEYY------------NVPCADDEQDLLKLKQ-KPSQKKPMVMRSDTNTHTSSKKDM 344
            |.:.|.:|.|.:            |....|:|::.:::|. .||.   :......:...|..:..
Frog    89 FHVDTPEEREEWIIAIQTVANGLKNQVAEDEEEEAMEVKYGSPSD---VSSAEQMDVAMSKGRPK 150

  Fly   345 IRATDFNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEKRVLALGEKPP 409
            :...||:::|:||||:||||:|...|.|...||:|||:|:|||..|:|..|:.|.|||. ..|.|
Frog   151 VTMNDFDYLKLLGKGTFGKVILVREKSSGRYYAMKILRKEVIIAKDEVAHTLTESRVLQ-NTKHP 214

  Fly   410 FLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGLFFLHTKGILYRD 474
            ||..|...|||.|||.|||||.|||:|.|.:.:...|.|..|.||.|||.:.|.:||::.::|||
Frog   215 FLTALKYAFQTSDRLCFVMEYANGGELFFHLSRERVFTEDRARFYGAEIVSALEYLHSRNVVYRD 279

  Fly   475 LKLDNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLL 539
            :||:|::||.||||||.|||:|||.|....|.:||||||:|:|||::....||::||||..||::
Frog   280 IKLENLMLDKDGHVKITDFGLCKEGITDGATMRTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVM 344

  Fly   540 YEMLVGQPPFDGEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTKQPNKRLGCGSSGEEDVRL 604
            |||:.|:.||..:|.|.||..|....:.:|::||.|||....|.|.|.|.:|||.|.:..::|..
Frog   345 YEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPNDAQEVMS 409

  Fly   605 HPFFRRIDWEKIENREVQPPFKPKIKHRKDVSNFDKQFTSEKTDLTPTDKVFMMNLDQSE----- 664
            |.||..|:|:.:..|::.|||||::....|...||.:||::...|||.|:  ..|||..|
Frog   410 HRFFASINWQDVTERKLTPPFKPQVTSEIDTRYFDDEFTAQSITLTPPDR--YDNLDALESDQRP 472

  Fly   665 -FVGFSY 670
             |..|||
Frog   473 HFPQFSY 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383
		C1_cPKC_rpt2	120..173	CDD:410386
		C2_PKC_alpha_gamma	177..307	CDD:175992	5/25 (20%)
		STKc_cPKC	353..672	CDD:270739	154/324 (48%)
akt2	NP_001116936.1	PH_PKB	4..112	CDD:269947	4/22 (18%)
akt2	NP_001116936.1	STKc_PKB_beta	160..482	CDD:173686	154/323 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D614710at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010