DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc53E and prkcb

DIOPT Version :9

Sequence 1:	NP_725626.1	Gene:	Pkc53E / 48311	FlyBaseID:	FBgn0003091	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	NP_001103513.1	Gene:	prkcb / 100038043	XenbaseID:	XB-GENE-486491	Length:	670	Species:	Xenopus tropicalis

Alignment Length:	664	Identity:	438/664 - (65%)
Similarity:	523/664 - (78%)	Gaps:	20/664 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 GENKMKSRLRKGALKKKNVFNVKDHCFIARFFKQPTFCSHCKDFICGYQSGYAWMGFGKQGFQCQ 86
            ||:......|||||::|||..||:|.|.|||||||||||||.|||        | ||||||||||
Frog    10 GEDTTTRFARKGALRQKNVHEVKEHKFTARFFKQPTFCSHCTDFI--------W-GFGKQGFQCQ 65

  Fly    87 VCSYVVHKRCHEYVTFICPGKDKGIDSDSPKTQHNFEPFTYAGPTFCDHCGSLLYGIYHQGLKCS 151
            ||.:||||||||:|||.|||.|||..||.|:::|.|:..||:.|||||||||||||:.|||:||.
Frog    66 VCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCE 130

  Fly   152 ACDMNVHARCKENVPSLCGCDHTERRGRIYLEINVKENLLTVQIKEGRNLIPMDPNGLSDPYVKV 216
            .|.||||.||..|||||||.|||||||||:::..::|.:|||.:.:.|||:|||||||||||||:
Frog   131 TCMMNVHKRCVMNVPSLCGTDHTERRGRIHIKAEIREEVLTVTVGDARNLVPMDPNGLSDPYVKL 195

  Fly   217 KLIPDDKDQSKKKTRTIKACLNPVWNETLTYDLKPEDKDRRILIEVWDWDRTSRNDFMGALSFGI 281
            |||||.|.:||:||:|||..|||.|||:..:.||..|||||:.:|:||||.||||||||:|||||
Frog   196 KLIPDPKSESKQKTKTIKCSLNPTWNESFKFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGI 260

  Fly   282 SEIIKNPTNGWFKLLTQDEGEYYNVPC-ADDEQDLLKLKQK-------PSQK--KPMVMRSDTNT 336
            ||::|...:||||||:|:||||:|||. .:.|:...:|:||       |..|  :..|:......
Frog   261 SELLKAGVDGWFKLLSQEEGEYFNVPVPPEGEEGNEELRQKFERAKIGPGTKAVEEKVVNPMPKV 325

  Fly   337 HTSSKKDMIRATDFNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEKRV 401
            ..:..:|.::.:||||:|||||||||||:||||||::||||||||||||:||||||||||:||||
Frog   326 DNNETRDRMKVSDFNFLKVLGKGSFGKVILAERKGTDELYAIKILKKDVVIQDDDVECTMVEKRV 390

  Fly   402 LALGEKPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGLFFLH 466
            |||..|||||.||||||||||||:||||||||||||:||||.|:||||.|||||||||.||.|||
Frog   391 LALSGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYQIQQVGRFKEPHAVFYAAEIAIGLLFLH 455

  Fly   467 TKGILYRDLKLDNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQPYGKSVD 531
            :|||:|||||||||:||::||:|||||||||||:....|||||||||||||||||.||||.||||
Frog   456 SKGIVYRDLKLDNVMLDSEGHIKIADFGMCKENMWDGVTTKTFCGTPDYIAPEIIAYQPYAKSVD 520

  Fly   532 WWAYGVLLYEMLVGQPPFDGEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTKQPNKRLGCGS 596
            |||:|:||||||.||.||:||||:|||.:|.:|||:||||:||||...|||.:||.|.||||||.
Frog   521 WWAFGILLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGP 585

  Fly   597 SGEEDVRLHPFFRRIDWEKIENREVQPPFKPKIKHRKDVSNFDKQFTSEKTDLTPTDKVFMMNLD 661
            .||.|::.|.|||.|||||:|..|:|||:|||...| :..||||.||.....|||.|...:.|:|
Frog   586 EGERDIKDHAFFRYIDWEKLERNEIQPPYKPKACGR-NAENFDKFFTRHPPVLTPPDHEVIRNID 649

  Fly   662 QSEFVGFSYMNPEY 675
            ||||.||||:|.::
Frog   650 QSEFEGFSYVNSDF 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383	47/65 (72%)
		C1_cPKC_rpt2	120..173	CDD:410386	36/52 (69%)
		C2_PKC_alpha_gamma	177..307	CDD:175992	83/129 (64%)
		STKc_cPKC	353..672	CDD:270739	236/318 (74%)
prkcb	NP_001103513.1	C1_1	34..86	CDD:278556	44/60 (73%)
		C1_1	99..149	CDD:278556	34/49 (69%)
		C2_PKC_alpha_gamma	156..286	CDD:175992	83/129 (64%)
		STKc_cPKC_beta	338..660	CDD:270767	240/322 (75%)
		S_TKc	339..597	CDD:214567	202/257 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	421	1.000	Domainoid score	I630
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	926	1.000	Inparanoid score	I354
OMA	1	1.010	-	-		QHG51944
OrthoDB	1	1.010	-	-		D143719at33208
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	1	1.000	-	-		otm49445
Panther	1	1.100	-	-	LDO	PTHR24356
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.080