Protein Alignment Pkc53E and prkcba

DIOPT Version :10

• Sequence 1: NP_725626.1
• Gene: Pkc53E / 48311
• FlyBaseID: FBgn0003091
• Length: 679
• Species: Drosophila melanogaster
• Sequence 2: NP_957323.1
• Gene: prkcba / 100006675
• ZFINID: ZDB-GENE-040426-1354
• Length: 668
• Species: Danio rerio
• Alignment Length: 687
• Identity: 440/687 - (64%)
• Similarity: 532/687 - (77%)
• Gaps: 37/687 - (5%)

  Fly     1 MSEGSDNNGDPQQQGAEGEAVGENKMKSRLRKGALKKKNVFNVKDHCFIARFFKQPTFCSHCKDF 65
            |:|.||::|   ::||.|.|          |:|||::|||..||||.|||||||||||||||.||
Zfish     1 MTESSDSDG---KEGARGFA----------RQGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDF 52

  Fly    66 ICGYQSGYAWMGFGKQGFQCQVCSYVVHKRCHEYVTFICPGKDKGIDSDSPKTQHNFEPFTYAGP 130
            |        | ||||||||||||.:||||||||:|.|.|||.|||..||.|:..|:|:..||..|
Zfish    53 I--------W-GFGKQGFQCQVCCFVVHKRCHEFVHFSCPGSDKGPASDDPRKYHSFKVHTYTSP 108

  Fly   131 TFCDHCGSLLYGIYHQGLKCSACDMNVHARCKENVPSLCGCDHTERRGRIYLEINVKENLLTVQI 195
            ||||||||||||:.|||::|..|.||:|.||.::||||||.||||:|||::...::..|:|:|.:
Zfish   109 TFCDHCGSLLYGLIHQGMRCLNCLMNIHKRCFKHVPSLCGTDHTEKRGRLHFSASITGNVLSVSV 173

  Fly   196 KEGRNLIPMDPNGLSDPYVKVKLIPDDKDQSKKKTRTIKACLNPVWNETLTYDLKPEDKDRRILI 260
            ||.|||:||||:||||||||:|||||.|.:||:||:|||.||||||||..|:.||..|||||:.:
Zfish   174 KEARNLVPMDPSGLSDPYVKLKLIPDPKSESKQKTKTIKGCLNPVWNEDFTFALKDTDKDRRLYV 238

  Fly   261 EVWDWDRTSRNDFMGALSFGISEIIKNPTNGWFKLLTQDEGEYYNVPC-ADDEQDLLKLKQKPSQ 324
            |||||||.:|||:||::||||||::....:||||:|..:||.::|||. .|:|:...:|.::..:
Zfish   239 EVWDWDRGTRNDYMGSMSFGISELMNQSVDGWFKILACEEGVFFNVPVYVDEEEGNKELSKRFER 303

  Fly   325 KKPMVMRSDTNTHTSSKKDM-----------IRATDFNFIKVLGKGSFGKVLLAERKGSEELYAI 378
            .|  :.....||..:||.|:           ::..|||||.||||||||||:|||||||:||||:
Zfish   304 AK--IGPGTNNTDGASKNDLSKYDANGNQDRMKLADFNFIMVLGKGSFGKVMLAERKGSDELYAV 366

  Fly   379 KILKKDVIIQDDDVECTMIEKRVLALGEKPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQF 443
            |||||||:||||||||||:|||||||..|||||..|||||||||||:|||||::||||||||||.
Zfish   367 KILKKDVVIQDDDVECTMVEKRVLALSGKPPFLTHLHSCFQTMDRLYFVMEYISGGDLMFQIQQT 431

  Fly   444 GKFKEPVAVFYAAEIAAGLFFLHTKGILYRDLKLDNVLLDADGHVKIADFGMCKENIVGDKTTKT 508
            ||||||:|||||.|||.||||||:|||:|||||||||:||::||:|||||||||||:....||||
Zfish   432 GKFKEPLAVFYAGEIAIGLFFLHSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENMFDKDTTKT 496

  Fly   509 FCGTPDYIAPEIILYQPYGKSVDWWAYGVLLYEMLVGQPPFDGEDEEELFAAITDHNVSYPKSLS 573
            |||||||||||||.|||||||||||||||||||||.||||||||||:|||.:|.:|:||||||:|
Zfish   497 FCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHHVSYPKSMS 561

  Fly   574 KEAKEACKGFLTKQPNKRLGCGSSGEEDVRLHPFFRRIDWEKIENREVQPPFKPKIKHRKDVSNF 638
            |||...|||.:||.|.||||||..||.|::.|.|||.:|||:::|:|||||:|||...| |..||
Zfish   562 KEAVAICKGLMTKHPGKRLGCGLEGERDIKEHAFFRFVDWERLQNKEVQPPYKPKSCGR-DAGNF 625

  Fly   639 DKQFTSEKTDLTPTDKVFMMNLDQSEFVGFSYMNPEY 675
            |..||.....|||.|...:.||||.||.||||:|.::
Zfish   626 DLFFTRHPPILTPPDLEVIQNLDQEEFRGFSYVNTKF 662

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383	48/65 (74%)
		C1_cPKC_rpt2	120..173	CDD:410386	33/52 (63%)
		C2_PKC_alpha_gamma	177..307	CDD:175992	78/129 (60%)
		STKc_cPKC	353..672	CDD:270739	239/318 (75%)
prkcba	NP_957323.1	C1_cPKC_rpt1	31..88	CDD:410383	48/65 (74%)
		C1_cPKC_rpt2	98..151	CDD:410386	33/52 (63%)
		C2_PKC_alpha_gamma	155..285	CDD:175992	78/129 (60%)
		Protein Kinases, catalytic domain	337..659	CDD:473864	243/322 (75%)