DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc53E and AKT3

DIOPT Version :9

Sequence 1:	NP_725626.1	Gene:	Pkc53E / 48311	FlyBaseID:	FBgn0003091	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	NP_001357003.1	Gene:	AKT3 / 10000	HGNCID:	393	Length:	479	Species:	Homo sapiens

Alignment Length:	344	Identity:	157/344 - (45%)
Similarity:	221/344 - (64%)	Gaps:	10/344 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   333 DTNTHTSSKKDMIRATDFNFIKVLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMI 397
            |.:|....:|.|   .||:::|:||||:||||:|...|.|.:.||:|||||:|||..|:|..|:.
Human   134 DASTTHHKRKTM---NDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLT 195

  Fly   398 EKRVLALGEKPPFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGL 462
            |.|||. ..:.|||..|...|||.|||.|||||||||:|.|.:.:...|.|....||.|||.:.|
Human   196 ESRVLK-NTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSAL 259

  Fly   463 FFLHTKGILYRDLKLDNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQPYG 527
            .:||:..|:||||||:|::||.|||:||.|||:|||.|....|.|||||||:|:|||::....||
Human   260 DYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYG 324

  Fly   528 KSVDWWAYGVLLYEMLVGQPPFDGEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTKQPNKRL 592
            ::||||..||::|||:.|:.||..:|.|:||..|...::.:|::||.:||....|.|.|.|||||
Human   325 RAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRL 389

  Fly   593 GCGSSGEEDVRLHPFFRRIDWEKIENREVQPPFKPKIKHRKDVSNFDKQFTSEKTDLTPTDKV-- 655
            |.|....:::..|.||..::|:.:.::::.|||||::....|...||::||::...:||.:|.
Human   390 GGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKYDE 454

  Fly   656 ----FMMNLDQSEFVGFSY 670
                .|.|..:..|..|||
Human   455 DGMDCMDNERRPHFPQFSY 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc53E	NP_725626.1	C1_cPKC_rpt1	44..110	CDD:410383
		C1_cPKC_rpt2	120..173	CDD:410386
		C2_PKC_alpha_gamma	177..307	CDD:175992
		STKc_cPKC	353..672	CDD:270739	151/324 (47%)
AKT3	NP_001357003.1	PH_PKB	4..110	CDD:269947
		STKc_PKB_gamma	132..479	CDD:270745	157/344 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	458..479		6/16 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D614710at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920