DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mus101 and DPB11

DIOPT Version :9

Sequence 1:	NP_524909.1	Gene:	mus101 / 48309	FlyBaseID:	FBgn0002878	Length:	1425	Species:	Drosophila melanogaster
Sequence 2:	NP_012445.1	Gene:	DPB11 / 853355	SGDID:	S000003626	Length:	764	Species:	Saccharomyces cerevisiae

Alignment Length:	901	Identity:	158/901 - (17%)
Similarity:	303/901 - (33%)	Gaps:	263/901 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 GGIYHRAFRSQVVDIVITEQTKTDTEKYKAAIRYKKDVLLPEWIFDSCNRGYALPTKDYEVRPGK 308
            |||:.:....| |::::...| |:|.|:|.|::::.|::..:  ..:.:..|.|......:.|..
Yeast    31 GGIFSKDLTRQ-VNVLVVGST-TNTNKFKFAVKHRFDIIFID--IQAIDDIYQLWLSGENILPDS 91

  Fly   309 TSSTPTKTTRPGAAPGADQTHLSDL-SRISF-------VSGSRRMCSDLSTVNESVSSVGSSSPA 365
            .::|.|         |:....|..| .|.||       :...|...:::::::..|.|:
Yeast    92 NTATMT---------GSTYEMLKILYRRFSFKYLHNFNIFIGRITDTNITSIDSLVRSI------ 141

  Fly   366 KQLLKQATSSGRNYQQVLAEIEPRQAKKAGAFLDGCCVYLSGFRSEEREKLNRVLNTGGATRYDE 430
                |:...|..|||..:                                   :.:|  ::..|:
Yeast   142 ----KKLGCSSYNYQNFV-----------------------------------IKDT--SSHNDD 165

  Fly   431 ANEG--------ISHIIVGQLDDAEYRQWQRDGLMGSVHVVRLDWLLESIRAGRV---------- 477
            .::|        ::..::|...:|...|        ::.:|...|:|:..:...:
Yeast   166 DDQGQNGQISIFVTDTLLGARVNAAIEQ--------NIPIVHFKWILDCQKRSALLPYDPYYLLP 222

  Fly   478 -VSELVH--------------RVSMPQNREPDVASPASKRTLRSMNHSFKQPTLPIKKKLFDQEP 527
             :.:|.:              ..:.|.|.:      |.....|..:.|...|:||
Yeast   223 NIKDLPYDSIGSNSCDCWDKINTTFPTNID------AQSSLQRQQSSSTLTPSLP---------- 271

  Fly   528 DPVQEQEHEEPDHTLLDQYSQDQGAVAQLPPADVSLLQPAASSTQMDIRQRVSVANPKPPAEGLQ 592
                      ...:||:::.         |..:  .:...|.|.|...:...||....|.:...:
Yeast   272 ----------KTSSLLNKFK---------PKGE--KIWDKAMSLQQHSKTNFSVLGQSPLSINNK 315

  Fly   593 LPDLSASTLSIDFDKLDYFAGVSVYVHRECFNEEFF----NQMLTECEAAQGLLVPSSFSDEV-- 651
            ..|||.::..|       |...:..:|      ..|    ..:||:.....|..:.:|:...:
Yeast   316 QEDLSDNSTLI-------FKNCAFIIH------HIFPGNHRSILTKIVVQNGGKIETSYLSGIYD 367

  Fly   652 --------DFAIVSFEVAFDVKQLPVKARHVVTELFLESCMKKNQLL-PIEYYHKHVPATALRQP 707
                    :.|:.||.   |:.::......:|||.|:|.|:...:|| ||:.:.|...:|...|.
Yeast   368 HSYYIIPSNKALDSFN---DLPEIIDDNDGIVTEFFIERCLYYQKLLHPIDLWSKPFLSTIEFQV 429

  Fly   708 LKG-------------MTIVVSIYAGLERDFINATAELL---GASVNKTFIKKEKPLLVCPSAEG 756
            ...             :.:.::.::|:|...:.....||   |.:..:...|....||:..:|..
Yeast   430 SSSSKLLHHEFSSSPFLNVTITGFSGVELLHLTKVLNLLKPMGINYVEYLNKSTDILLINLAALP 494

  Fly   757 SKYEGAIKWNYPVVT---SDWLVQ-CARTGQKLPFVGYLVGKSPEDFPISPRLRDSNSRTARRPN 817
            |     |...:|:.:   ||...| |.......|     ...:.:||..:..||:|..|......
Yeast   495 S-----IPKTHPLWSNEFSDLFTQFCINNNNDDP-----GDNNRKDFQNNSILRNSMKRKIEYIK 549

  Fly   818 ESTLVAQPDVTMEEAENQPAGSVTPVTAGSPGAPELTPLRNKRVSELAGIPGGSALHRGSNSTSS 882
            :...:  |.||       ||.....::|.|....|:. |.|.:...:.  |.|   |:.......
Yeast   550 KFHSI--PVVT-------PAFIFKLLSAASGENNEIF-LNNIKWCIIC--PRG---HKDDFKCKI 599

  Fly   883 PDSPCTPLSQVGAQQYN---LD---FLEQFVQRLDTEEGKDCVREIIREMRENQTPELERIRRQA 941
            .....|.:|.....|.|   :|   .|::....|.....||...|:::::||..:...:|....:
Yeast   600 KKPYYTSISSEKKYQNNDPKIDKTILLKRNNSSLSEHSMKDTKNELLQKIRETDSGRKKRSVSSS 664

  Fly   942 CTPVSRKHQRPAPGIPDFCLTPEFQQRMADDFERRWRLPTMKIKPDT-PLAVIRQRVMRITCETL 1005
            ...||.:.|.|                           .|.:||.:: |...:.:::.|.|  :.
Yeast   665 IMDVSSERQMP---------------------------DTKRIKLESLPKNFVPKQIKRTT--SW 700

  Fly  1006 G-IEYEESNAKTPTLSESPSTVKKKPPTRTTQATKLNFDRSPKTPKLSLGKKTPLR 1060
            | |..|....:.||...:|..:.:......||.|..:.....:|..|    :.|:|
Yeast   701 GTIMSENVPTEQPTAISNPEEIPRTEEVSHTQVTYGSIQDKKRTASL----EKPMR 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mus101	NP_524909.1	BRCT	118..188	CDD:278934
		BRCT	216..290	CDD:278934	12/45 (27%)
		BRCT	397..472	CDD:278934	9/82 (11%)
		BRCT	707..778	CDD:278934	15/90 (17%)
		BRCT	1210..1279	CDD:237994
DPB11	NP_012445.1	BRCT	2..85	CDD:412126	14/57 (25%)
		BRCT	111..206	CDD:395424	19/149 (13%)
		BRCT_Rad4_rpt3	326..410	CDD:349386	18/99 (18%)
		BRCT	446..>489	CDD:412126	8/42 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1929
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003632
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102493
Panther	1	1.100	-	-	LDO	PTHR13561
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1061
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.930