DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mus101 and MEI1

DIOPT Version :9

Sequence 1:	NP_524909.1	Gene:	mus101 / 48309	FlyBaseID:	FBgn0002878	Length:	1425	Species:	Drosophila melanogaster
Sequence 2:	NP_001323210.1	Gene:	MEI1 / 844068	AraportID:	AT1G77320	Length:	1001	Species:	Arabidopsis thaliana

Alignment Length:	834	Identity:	182/834 - (21%)
Similarity:	321/834 - (38%)	Gaps:	179/834 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 TLQQFEAA-----RELLGQQLAETQIRQIK-----------PSEGYPLIAAGNLTKKDVFVLTQF 79
            |.|.|:.|     |.|:..::.:|.:...|           ||...|         .|..|:...
plant     3 TTQLFKGANVFMSRNLVPPEVFDTLLDAFKLNGAEIFLCCDPSRSGP---------SDFHVIASP 58

  Fly    80 EGEFFEQLQQTRALILGPPCLITCLRRNEPIPEGSSAIYSTAMRDLQVSATGITPQKKEELSRLI 144
            :.|.|:.|:.....::||.|.:.|.:...|:|:..... ..||..|:|.|:|....:|.::..|:
plant    59 DHEKFKDLKAKGCNLIGPQCALFCAKEGRPLPQRGFTC-CLAMDGLKVLASGFLVDEKVKIKELV 122

  Fly   145 NWMGGIYFQSFGHRTTHLISNTIKSSKYEQATLNGVPVMHVDWVQYVWDQSRRSQREGIMATDPD 209
            ..|||:...........:|...:.::||:.| ||..|::.::|:...|::.|      ::..:|
plant   123 TSMGGVLLSRASSDVNFVIVKNVLAAKYKWA-LNKKPIVTLNWLHRCWNEHR------VVPQEP- 179

  Fly   210 FDKYRLPIFFGANITCSGLDVARKDQVMRLVNDNGGIYHRAFRSQVVDIVITEQTKTDT------ 268
               |::|.|.|..|..:.:....:..:.:::::.||.|.            .|.||:.|
plant   180 ---YKIPPFSGLTICVTRIPADERKGMEKVISEYGGSYS------------AELTKSCTHLIADA 229

  Fly   269 ---EKYKAAIRYKK-DVLLPEWIFDSCNRGYALPTKDYEVRPGKTSSTP-TKTTR---------- 318
               :|||.|.::.. .::..:|...|.::...|..:.|.|    ..|.| |:..|
plant   230 AEGDKYKVARKWGHIQIVTRKWFQQSIDKKVCLNEESYPV----LGSIPLTRGVRDLGVHNGLEK 290

  Fly   319 -PGA--APGADQTHLSDLSRISFVSGSRRMCSDL-STVNESV--SSVGSSSPAKQLLKQATSSGR 377
             |.|  |..||          |:||.::...||: ::.:::|  :|:..|:..|:  .....:.|
plant   291 FPSAATASAAD----------SYVSCAQSRDSDIEASASQNVFPTSMNPSTDVKE--PGGGPTAR 343

  Fly   378 NYQQVLAEIEPR--QAKKAGAFLDGCCVYLSGFRSEEREKLNRVLNTGGATRYDEANEGISHIIV 440
            ..:|.:.....|  :::....:|..|.::|.||.:.|..||.:::..||.:||...||.::||:|
plant   344 PQEQNIDGCTARDSESEDNDLYLSDCRIFLLGFEASEMRKLAKLVRRGGGSRYMLLNERMTHIVV 408

  Fly   441 GQLDDAEYRQWQRDGLMGSVHVVRLDWLLESIRAGRVVSELVHRV-------------------- 485
            |...::|.|:.:.....|.:.||...||.:..|..:.:.  ||.:
plant   409 GTPSESEKREARSVAASGVIQVVIPSWLEDCDREKKEIP--VHNIYTANHLILPRDSACLTKGSF 471

  Fly   486 ----SMPQNREPDVASPASKRTLRSMNHSFKQPTLPIKKKLFDQEPDPVQEQEHEEPDHTLLDQY 546
                ||.|.:.....:.....:.||:|.|....||..|.|      :.:||...::..||
plant   472 ARMSSMEQTKNTHDQTMVYDSSSRSINVSNGPATLLGKNK------EAMQEFGRKDEIHT----- 525

  Fly   547 SQDQGAVAQLPPADVSL--LQPAASSTQMDIRQRVSVANPKPPAEGLQLPDLSASTLSIDFDKLD 609
                |.....|....:|  |....|..|..|:...|..|.:.                   .|..
plant   526 ----GRKIVSPTQKETLISLVTCESKEQRSIQCEFSGQNDQE-------------------RKSS 567

  Fly   610 YFAGVSVYVHRECFNEEFFN----QMLTECEAAQGLLVPSSFSDEVDFAIV---SFEVAFDVKQL 667
            .|.|.:.     ||:..|..    |::.......|.:|.....:...|.|.   .|:.....:.:
plant   568 VFKGETF-----CFSHSFPEDRRPQIVEWVNQGGGEVVNDPLINNAHFTIECHGGFQSTETTQTI 627

  Fly   668 PVKARHVVTELFLESCMKKNQLLPIEYYHKHVPATALRQPLKG---MTIVVSIYAGLERDFINAT 729
            .|.:.      ::.:|:|...||.:..:..:.|... :.||.|   :.|..|.:.....:.:...
plant   628 YVSSH------WVRNCLKVGCLLAVSSHILYSPLPC-QTPLPGFESLCICSSQHNEKNVELLRNL 685

  Fly   730 AELLGASVNKTFIKKEKPLLVCPSAEGSKYEGAIKWNYPVVTSDWLVQCARTGQ 783
            :.:|||...:...:|... |:|..|:|.||..|.||....||.|||.:|.|..|
plant   686 SVVLGADFVERLTRKVTH-LICNFAKGDKYVRASKWGIISVTPDWLYECVRQNQ 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mus101	NP_524909.1	BRCT	118..188	CDD:278934	18/69 (26%)
		BRCT	216..290	CDD:278934	16/83 (19%)
		BRCT	397..472	CDD:278934	25/74 (34%)
		BRCT	707..778	CDD:278934	23/73 (32%)
		BRCT	1210..1279	CDD:237994
MEI1	NP_001323210.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	53	1.000	Domainoid score	I4226
eggNOG	1	0.900	-	-		E1_KOG1929
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D557169at2759
OrthoFinder	1	1.000	-	-		FOG0003632
OrthoInspector	1	1.000	-	-		oto3168
orthoMCL	1	0.900	-	-		OOG6_102493
Panther	1	1.100	-	-	LDO	PTHR13561
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.820