Protein Alignment mus101 and SLF1

DIOPT Version :10

• Sequence 1: NP_524909.1
• Gene: mus101 / 48309
• FlyBaseID: FBgn0002878
• Length: 1425
• Species: Drosophila melanogaster
• Sequence 2: NP_115666.2
• Gene: SLF1 / 84250
• HGNCID: 25408
• Length: 1058
• Species: Homo sapiens
• Alignment Length: 232
• Identity: 72/232 - (31%)
• Similarity: 107/232 - (46%)
• Gaps: 40/232 - (17%)

  Fly  1198 GSPK--MQYAGIPCFSISCGDDDEKRAELIARI--TQLGGKVCENLVNYDDSCTHLLCERPNRGE 1258
            |:||  :|..|...      ::.|...:|:.::  |.:..:..:|       ||||:.||..:.|
Human     4 GTPKHIIQMTGFKM------EEKEALVKLLLKLDCTFIKSEKYKN-------CTHLIAERLCKSE 55

  Fly  1259 KMLACIAAGKWILNIQYIEQSHARGDFLDETLYEWGNPKAINLPTLAPEEEPIAAAVHRWRTELS 1323
            |.||..|||||||...||..|...|.:||||.||||. |.......:|:   :.:|..|||.||.
Human    56 KFLAACAAGKWILTKDYIIHSAKSGRWLDETTYEWGY-KIEKDSRYSPQ---MQSAPKRWREELK 116

  Fly  1324 ACGG-GAFSDHRVILSM--NERSGAPIRNVLRAGGACILEP-TTPFSKDPVAKSASHCFVDVK-- 1382
            ..|. |||...:|:|.:  ::||.:.|| ||.||.|.::.| ::|.....|..|.:....:.:
Human   117 RTGAPGAFHRWKVVLLVRTDKRSDSLIR-VLEAGKANVILPKSSPSGITHVIASNARIKAEKEKD 180

  Fly  1383 --KAPLSTQDMEYLHKCGVQVLSQIAINAYLMNGRDA 1417
              |||...          :|.|....:...:.|..|:
Human   181 NFKAPFYP----------IQYLGDFLLEKEIQNDEDS 207

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mus101	NP_524909.1	BRCT	127..189	CDD:349339
		BRCT_TopBP1_rpt2_like	216..294	CDD:349363
		BRCT_TopBP1_rpt3	392..476	CDD:349350
		BRCT	707..786	CDD:469589
		BRCT_TopBP1_rpt7	1208..1283	CDD:349370	24/76 (32%)
		BRCT	1334..1414	CDD:469589	20/86 (23%)
SLF1	NP_115666.2	BRCT_SLF1	5..85	CDD:349381	30/92 (33%)
		BRCT	127..198	CDD:469589	20/81 (25%)
		NSE5-like domain, mediates interaction with SLF2. /evidence=ECO:0000269|PubMed:36373674	410..1058
		ANKYR	<796..>916	CDD:440430
		ANK repeat	807..838	CDD:293786
		ANK repeat	840..871	CDD:293786
		ANK repeat	874..904	CDD:293786