DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mus101 and topbp1

DIOPT Version :9

Sequence 1:	NP_524909.1	Gene:	mus101 / 48309	FlyBaseID:	FBgn0002878	Length:	1425	Species:	Drosophila melanogaster
Sequence 2:	NP_001186667.1	Gene:	topbp1 / 407679	ZFINID:	ZDB-GENE-060626-1	Length:	1526	Species:	Danio rerio

Alignment Length:	1644	Identity:	386/1644 - (23%)
Similarity:	642/1644 - (39%)	Gaps:	391/1644 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 AYFVNNLKPGDGGVQEAD-TLQQFEAARELLGQQLAETQIRQIKPSEGYPLIAAGNLTKKDVFVL 76
            ||.|   |..:...|::| .||.::|..||    .:|..::.:.......|    :...|.:||.
Zfish     8 AYIV---KFVESNGQKSDVALQAYKAIVEL----QSEKYVQMVDEEAALEL----DHNDKSLFVF 61

  Fly    77 TQFEGEFFEQLQQTRALILGPPCLITCLRRNEPIPEGSSAIYSTAMRDLQVSATGITPQKKEELS 141
            :.|....|:..::....|:.|..::.||::...:|:....:|:.:|.|:.||.|.:..:.:.|:.
Zfish    62 SDFTSSAFDHCRRLGCRIVSPLVVLFCLQKQRCVPKAEQPVYNMSMADVTVSCTNLDKEARSEVM 126

  Fly   142 RLINWMGGIYFQSFGHRTTHLISNTIKSSKYEQATLNGVPVMHVDWVQYVWDQSRRSQREGIMAT 206
            .||..|||..::......|||::..:.|.||..|...|.|::...||:..|:   :||......:
Zfish   127 DLIQLMGGRVYRDLNVSVTHLVAGEVGSKKYLVAASLGKPILLPSWVKACWE---KSQDSVFHHS 188

  Fly   207 DPDFDKYRLPIFFGANITCSGLDVARKDQVMRLVNDNGGIYHRAFR-SQVVDIVITEQTKTDTEK 270
            :.:.:.||.|:..|..:..:||....:.:|.||.:.||..|....: ::...:::.|.|   .:|
Zfish   189 ELNTEDYRCPVLKGCTVCVTGLSTVERKEVQRLCDQNGATYTGQLKMNECTHLIVNEPT---GQK 250

  Fly   271 YKAAIRYKKDVLLPEWIFDSCNRGYALPTKDYEVRPGKTSSTPTKTTRPGAAPGADQTH------ 329
            |:.|.::....:...|:|||..:|:......|.|..|....|..|:.||..:....|:.
Zfish   251 YEFARKWNVYCVSLHWLFDSIEKGFCQDESRYAVERGDKRKTDDKSGRPNTSTPTGQSRSKEDGP 315

  Fly   330 -LSDLSRISFVSGSRRMCSDLSTVNESVSSVGSSSPAKQLLKQATSSGRNYQQVLAEIEPRQAK- 392
             |..||.||.:|         ..|||:.               .|::|.::.::...::.....
Zfish   316 SLLGLSHISNIS---------LNVNETA---------------LTTAGISHIEMPDPVDSFDITV 356

  Fly   393 -KAGAFLDGCCVYLSGFRSEEREKLNRVLNTGGATRYDEANEGISHIIVGQ--------LDDAEY 448
             :....||||.:||.|...::.|||.|::||.|..|:::..:.::||::|:        ||:|.:
Zfish   357 CRVDDLLDGCKLYLCGLSGKKLEKLRRMVNTAGGLRFNQPTQELTHIVMGEADQGIKAFLDNATH 421

  Fly   449 RQWQRDGLMGSVHVVRLDWLLESIRAGRVVSE-------------------LVHRVSMPQNREPD 494
            |.          |:|.:.|||||...|.::.|                   .:|:.: |:...|.
Zfish   422 RP----------HIVTVQWLLESFSRGSLLPENGYFHPSFLPPAPAAVDIPALHKAA-PRASRPS 475

  Fly   495 VASPASKRTLRSMNHSFKQPTLPIKKKLFDQEPDPVQEQEHEEPDHTLLDQY-SQDQGAVAQLPP 558
            ||.|.:                          |.|.::...||   .||.|| ..||  ..:||
Zfish   476 VAPPPA--------------------------PSPARQSRAEE---DLLSQYMGNDQ--TVELP- 508

  Fly   559 ADVSLLQPAASSTQMDIRQRVSVANPKPPAEGLQLPDLSASTLSIDFDKLDYFAGVSVYVHRECF 623
                          .|...|.||.:|:|..||.......||...:.|.|.....|         |
Zfish   509 --------------QDTSSRHSVLHPEPLVEGKDSTLAEASEGGLFFGKRFILVG---------F 550

  Fly   624 NEEFFNQMLTE--CEAAQGLLVPSSFSDEVDFAIVSFEVAFDVKQLPVKARHVVTELFLESCMKK 686
            ..|...| |:|  .|.|..:||..|.: ...:|||.. :..||:   .....|.|:.:|..|:::
Zfish   551 GAEAEAQ-LSELVMENAGKILVGRSRA-VAHYAIVPL-LGCDVE---ATVDEVATDTWLAMCVEQ 609

  Fly   687 NQLLPIEYYHKHVPATALRQ---PLKGMTIVVSIYAGLERDFINATAELLGASVNKTFIK---KE 745
            ..:||:..:....| .|:|:   |||...:.||.:.|.|||.:...|:.|||||...|::   :.
Zfish   610 QCVLPLASHPLFTP-VAVREGFSPLKDCVLSVSQFTGAERDSLIQLAKHLGASVQDYFVRTANQR 673

  Fly   746 KPL-----LVCPSAEGSKYEGAIKWNYPVVTSDWLVQCARTGQKLPFVGYLVGKSPEDFPISP-R 804
            |.:     ||..:.||:||:.|.||..|.||..|:::.||||::.....|||     |.|.|| |
Zfish   674 KGMLASTHLVLQTPEGTKYQAAQKWGLPAVTIRWVLESARTGKRADEGQYLV-----DLPPSPER 733

  Fly   805 LRDSNSRTARRPNESTLVAQ--PDVTMEEAENQPAGSVTPVTAGSPGAPELTPLRNKRVSELAGI 867
            ..||....:::......:.|  |::.:...:|..|               :|||...|....:..
Zfish   734 TEDSFVGASQKDPPPLRLHQRSPELPLLGPQNSDA---------------ITPLDTARFQSRSVR 783

  Fly   868 PGGSALHRGSNSTSSPDSPCTPLSQVGAQQ----YNLDFLEQFVQR-------LDTEEGKDCVRE 921
            .....|.:|....:...:|....:: ||||    .:||...:|:.|       .:|::..|.::.
Zfish   784 SAVRKLKQGEEEQAEVTTPGQEEAK-GAQQKDSSLHLDTPSRFLSRDKLFGPSFNTKDVFDHLQT 847

  Fly   922 IIREMRENQ---TPELERIRRQACTPVSRKHQRPAPGIPDFCLTPEFQQRMADDFERRWRLPTMK 983
            ...:.::.|   ||..|.|.|.....|:..::.....:.....:|:..:....:.|:
Zfish   848 PGNKSQQGQGAETPLSEVIERNLKAAVANSNRSHVTNLAAMTASPQLGKEPEPEVEQ-------- 904

  Fly   984 IKPDTPLAVI----------RQRVMRITCETLGIEYEES----------------NAK------- 1015
             |...||:.:          :|..:.....:||.|:..|                |:|
Zfish   905 -KAAAPLSGVVVCVSKKLSKKQSELNAVAASLGAEFRWSCDDSVTHYIYQGKVGDNSKEYRAVKE 968

  Fly  1016 ----------------------------------TPTLSESPSTVKKKPPTRTTQATKLNFDRSP 1046
                                              :.|:|:...:.::.||:.|.:.....|..:.
Zfish   969 RGLYIVSQHWLQACADEQKHVSESLYPFTFNPKMSLTMSQMADSTQRSPPSATPRTRLRAFAENE 1033

  Fly  1047 KTPKLSLGK-------KTPLRVSMGSP-RSGTQSPFVPNTQSPIEAAPPRRSDGPTLSEEGQSTI 1103
            :|   .||.       .||.:.|:|.| :..|.|....|....:|.   |.|    |..:.|..:
Zfish  1034 ET---RLGPDDDITDVSTPKQGSVGEPEKDQTISTEKKNLTETLEM---RES----LQRQLQEIM 1088

  Fly  1104 NFDKISFEESAVPVLAP------DVPTVAPDVKQITDYLKNCESRRNSLKRSHDNDMDCGESE-- 1160
            :..|::........||.      |.|.....:.:::...:|.|:.|.|.:...|.:.:..:||
Zfish  1089 SATKLTSGRRGSSRLAKTGPGGLDSPHTPDSLGRMSRRSRNLEAIRMSRQVCVDLNTEPSQSEQI 1153

  Fly  1161 ------------------------------VQYVQPFESEGFALGTEDMVDWR--DPAEFNA--A 1191
                                          :..|.|..|:....|.:.|.|..  :.|.|..  |
Zfish  1154 VWDDPTAREERAKLADNLQWPGSPSQHSEPLALVPPPHSDHTTNGRDSMTDSELVEMAAFEVIDA 1218

  Fly  1192 KRRSSGGS--------PKMQYAGIPCFSIS---------CGDDDE-----------------KRA 1222
            :.:..|.|        ||...|....|.||         ..|::|                 :|.
Zfish  1219 QLKPKGTSSRVDTLHNPKTPEAPSIAFPISKTAALPLPRIEDEEEELKKDPPRFLLSSLNPQERI 1283

  Fly  1223 ELIARITQLGGKVCENLVNYDDSCTHLLCERPNRGEKMLACIAAGKWILNIQYIEQSHARGDFLD 1287
            :....|.:|||.|.|. .::|.||||::...|.|.||.||.:|||||||:..|:|...|.|.|:.
Zfish  1284 DYSHLIEELGGVVLEK-QSFDPSCTHVIVGHPLRNEKYLAAMAAGKWILHRSYLEACRAEGHFIQ 1347

  Fly  1288 ETLYEWGNPKAIN-LPTLAPEEEPIAAAVHRWRTELSACGG---------GAFSDHRVILSMNER 1342
            |..||||:...:. ||::..:::.:|.|..|||..|..|..         |||....|:|::::.
Zfish  1348 EDQYEWGSSSILEALPSINSQQKRLALAAMRWRKTLQGCSNKEPNVIVVQGAFGGWIVMLNIDQA 1412

  Fly  1343 SGAPIRNVLRAGGACILEPTTPFSKDPVAKSASHCFVDVKK-APLSTQ-DMEYLHKCGVQVLSQI 1405
            ..|..|.:|::|||.:|...:|    .:.|..:|.|||..: .|...: |:......||:.|...
Zfish  1413 REAGFRRLLQSGGAKVLPDPSP----SLFKETTHLFVDFSRLKPGDVRVDISEASAHGVKCLKPE 1473

  Fly  1406 AINAYLMNGRDADLGKYQL 1424
            .|..|||......:..|.|
Zfish  1474 YIADYLMQEPSPSMDAYYL 1492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mus101	NP_524909.1	BRCT	118..188	CDD:278934	21/69 (30%)
		BRCT	216..290	CDD:278934	17/74 (23%)
		BRCT	397..472	CDD:278934	28/82 (34%)
		BRCT	707..778	CDD:278934	30/78 (38%)
		BRCT	1210..1279	CDD:237994	32/94 (34%)
topbp1	NP_001186667.1	BRCT	109..178	CDD:237994	21/68 (31%)
		PTCB-BRCT	203..266	CDD:289507	13/65 (20%)
		BRCT	359..435	CDD:278934	28/85 (33%)
		PTCB-BRCT	636..707	CDD:289507	26/70 (37%)
		BRCT	909..982	CDD:278934	9/72 (13%)
		BRCT	1272..1339	CDD:237994	27/67 (40%)
		BRCT	<1418..1479	CDD:214602	18/64 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I10370
eggNOG	1	0.900	-	-		E1_KOG1929
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	335	1.000	Inparanoid score	I2386
OMA	1	1.010	-	-		QHG48684
OrthoDB	1	1.010	-	-		D305707at33208
OrthoFinder	1	1.000	-	-		FOG0003632
OrthoInspector	1	1.000	-	-		oto41148
orthoMCL	1	0.900	-	-		OOG6_102493
Panther	1	1.100	-	-	LDO	PTHR13561
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1061
SonicParanoid	1	1.000	-	-		X5299
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.870