DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mus101 and Topbp1

DIOPT Version :9

Sequence 1:	NP_524909.1	Gene:	mus101 / 48309	FlyBaseID:	FBgn0002878	Length:	1425	Species:	Drosophila melanogaster
Sequence 2:	XP_038938515.1	Gene:	Topbp1 / 315969	RGDID:	1562949	Length:	1594	Species:	Rattus norvegicus

Alignment Length:	1613	Identity:	373/1613 - (23%)
Similarity:	614/1613 - (38%)	Gaps:	384/1613 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 YFVNNLKPGDGG---VQEADTLQQFEAARELLGQQLAETQIRQIKPSEGYPLIAAGNLTKKDVFV 75
            :||..||..|..   .:..:::::.::...|  |.:.:.:..:||.::            |.:::
  Rat    84 FFVKFLKSSDNSECFFKALESIKELQSEEYL--QVITDEEALRIKEND------------KSLYI 134

  Fly    76 LTQFEGEFFEQLQQTRALILGPPCLITCLRRNEPIPEGSSAIYSTAMRDLQVSATGITPQKKEEL 140
            ..:|.|..|:.|:|....|:||..:..|:|..:.:|.....:|:..|.|:.:|.|.:...|:||:
  Rat   135 CDRFSGTAFDHLKQLGCRIVGPQVVTFCMRHQQCVPRAEHPVYNMIMSDITISCTSLDKDKREEV 199

  Fly   141 SRLINWMGGIYFQSFGHRTTHLISNTIKSSKYEQATLNGVPVMHVDWVQYVWDQSRRSQREGIMA 205
            .:.:..|||..::......||||:..:.|.||..|.....|::...|::.:|::|:  :::....
  Rat   200 HKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPAWIKTLWEKSQ--EKKITKY 262

  Fly   206 TDPDFDKYRLPIFFGANITCSGLDVARKDQVMRLVNDNGGIYHRAFRSQVVDIVITEQTKTDTEK 270
            ||.:.:.::.|||.|..|..:||:...:..|.:|...:||.|....:......:|.::.|  .:|
  Rat   263 TDVNMEDFKCPIFLGCIICVTGLNGIHRKTVQQLTAKHGGQYMGQLKMNECTHLIVQEPK--GQK 325

  Fly   271 YKAAIRYKKDVLLPEWIFDSCNRGYALPTKDYEVRPGKTSSTPTKTTRPGAAPG---ADQTHLSD 332
            |:.|.|:....:..:|..||..:|:......|:..|.....|...|:.|.|..|   |:...|:|
  Rat   326 YECARRWNVHCVTLQWFHDSIEKGFCQDESIYKAEPRAAVKTVPDTSTPTAQSGSAAAENHRLAD 390

  Fly   333 LSRISFVSGSRRMCSDLSTVNESVSSVGSSSPAKQLLKQATSSGRNYQQVLAEIEPRQAKKAGAF 397
            :|.||.::||   |     |||::  .||::      .:...:..|.:.:  :|...||.:  ..
  Rat   391 VSHISNINGS---C-----VNETM--FGSTT------SKLECTXENLENL--DISMFQAPE--DL 435

  Fly   398 LDGCCVYLSGFRSEEREKLNRVLNTGGATRYDEANEGISHIIVGQLDDAEYRQWQRDGLMGSVHV 462
            ||||.:||.||...:.:||.|::|:||..|:::.||.::|:|:|..:|...:.|.:..  ...||
  Rat   436 LDGCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIMGDYEDDVRQFWSKSS--HRPHV 498

  Fly   463 VRLDWLLESIRAGRVVSE--LVHRVSMPQNREPDVASPASKRTLRSMNHSFKQPTLPIKKKLFDQ 525
            |...||||.:..|.::.|  .:|     .|.:|| ..|.|       :....|.|:..|...|.:
  Rat   499 VGAKWLLECLVKGYILPEESYIH-----ANYQPD-GIPVS-------DQPRNQTTVLEKSGTFSK 550

  Fly   526 EPDPVQEQEHEEPDHTLLDQYSQDQGAVAQL-----------PPADVSLLQPAASSTQMDIRQ-- 577
            : |.|..::.::.|..||.||..|...:.:.           |....:.::|...||.:.:::
  Rat   551 K-DFVPNEKFQQTDEDLLAQYVHDDSTIVEAKLSEAIEPEVGPCGGSAHVEPCDDSTHISVQEEN 614

  Fly   578 RVSVAN-----PKPPAEGLQLPDLSASTLSIDFDKLDYFA-GVSVYVHRECFNEEFFNQMLTECE 636
            :.||::     ...|.|||             |.:..:.. |.|  |..||.......:     .
  Rat   615 KSSVSHCLLDGSTVPEEGL-------------FSQKSFLVLGFS--VENECNIVNIIRE-----H 659

  Fly   637 AAQGLLVPSSFSDEVDFAIVSF---EVAFDVKQLPVKARHVVTELFLESCMKKNQLLPIEYYHKH 698
            |.:.:.:||..  ..|:|:|..   ||...|.:       |||..:|.:|:....|:..:.....
  Rat   660 AGKIVSLPSRI--VADYAVVPLLGCEVEATVAE-------VVTNTWLVTCIDNQTLVDPKSNPLF 715

  Fly   699 VPATAL--RQPLKGMTIVVSIYAGLERDFINATAELLGASVNKTFIKKEKPL--------LVCPS 753
            .|.:.:  ..||:...|..|...|.|||.:...|..|||||.:.|::|....        |:...
  Rat   716 TPVSVMSGMTPLEDCVISFSQCVGAERDSLVFLANHLGASVQEFFVRKSNAKKGMLASTHLIVKE 780

  Fly   754 AEGSKYEGAIKWNYPVVTSDWLVQCARTGQKLPFVGYLVGKSPEDFPISPRLRDSNSRTARRPNE 818
            ..|||||.|.||:.|.|...||::.||.|::.....:||..:|:    ..::.::|......||.
  Rat   781 PTGSKYEAAKKWSLPAVNISWLLETARMGKRADENHFLVDSAPK----QEQVLETNIPNGVSPNP 841

  Fly   819 STLVAQPDVTMEEAENQPAGSVTPVTAGSPGAPELTPLRNKRVSELAGIPGGSALHRGSNSTSSP 883
            .: .|.||..: |...|.|               :|||...|..       ..|.|...:..:..
  Rat   842 DS-PAHPDAHL-EIHRQKA---------------VTPLDMNRFQ-------SKAFHAVISQHNRQ 882

  Fly   884 DSPCTPLSQVGAQQ--YNLDFLEQFVQR----------------LDTEEGKDCVREIIREMRE-- 928
            .....|:.|...::  ::||...:|:.:                |:|.......|::...:.|
  Rat   883 GLASPPVRQPPKKEPSFHLDTPSKFLSKDKLFKPSFDVTDALAALETPNAASQKRKLSSPLSEVI 947

  Fly   929 --NQTPEL-ERIRRQACTPVS--------RKHQRPAP--------------------GIP----- 957
              |.|..| ...|...|...|        .|.:.|.|                    |:.
  Rat   948 VRNLTTALANSSRNTGCLSASPQLKGAHLEKEETPKPLDKVVVCVSKRLSKKQSELNGVAASLGA 1012

  Fly   958 ------DFCLTPEFQQRMADDFER---------------RWRL-------------------PTM 982
                  |..:|....|..|:|..|               .|.|                   |.|
  Rat  1013 EYRWSFDETVTHYIYQGRANDSNREYKSAKERGVHVVSEHWLLECAQEYKHLPESLYPHTYNPKM 1077

  Fly   983 KIKPDT-----------PLAVIRQR--------VMRITCETLGIEYEES---------------- 1012
            .:...|           |.|:...:        |.....||||....||
  Rat  1078 SLDISTVQDGRLCDSRLPSALSASKDDEPDHLSVEENATETLGTHSRESALLNGNGRDDCKGAMF 1142

  Fly  1013 -------NAKTPTLSESPSTVKKKPPTRTTQATKLNFDRSPKTPKLSLGKKTPLRVSMGSPRSGT 1070
                   |.:........:|...:.|.:.|..::.:.:.:..||.           |..|.|||.
  Rat  1143 QCLEMRENFQKQLQEIMSATSIVRTPAQKTCMSRSSCNSASSTPD-----------STRSARSGR 1196

  Fly  1071 QSPFVPNTQS-----PIEAAPPRRS----DGPTLSEE-----------------GQSTINFDKIS 1109
            ........||     .|...|.:..    |.||..||                 .:..:...|:.
  Rat  1197 SRVLEALRQSRQIVPDINTEPSQNEQIIWDDPTAREERARLASNLQWPSYPTQYSELQVEIKKLD 1261

  Fly  1110 FEESAVPVLAPDVPTVAPDVKQITDYLKNCE------SRRNSLKRSHDNDMDCGESEVQYVQ-PF 1167
            ...|..||...::...|..|.|........|      :.||.:.          |.:...|. |.
  Rat  1262 DSPSRKPVYHSEIAGQASCVTQAPGQHPGSEEPEAPAAERNLIP----------EPQAPSVAFPL 1316

  Fly  1168 ESEGFALGTEDMVDWRDPAEFNAAKRRSSGGSPKMQYAGIPCFSISCGDDDEKRAELIARITQLG 1232
            .....|...||.::..:          .:.|..|.||.    |.:|..:..| |.:....|..||
  Rat  1317 AKPPVAPQPEDKIETLE----------ETHGKLKKQYV----FQMSSLNSQE-RIDYCRLIKDLG 1366

  Fly  1233 GKVCENLVNYDDSCTHLLCERPNRGEKMLACIAAGKWILNIQYIEQSHARGDFLDETLYEWGNPK 1297
            |.|.|...: |.||||::...|.|.||.||.:|||||:|:..|::.....|.|:.|..||||:..
  Rat  1367 GSVIEKQCS-DPSCTHMVVGYPLRNEKYLASMAAGKWVLHRSYLDACRTAGRFVQEEDYEWGSSS 1430

  Fly  1298 AIN-LPTLAPEEEPIAAAVHRWRTEL-----SACGGGAFSDHRVILSMNERSGAPIRNVLRAGGA 1356
            .:: ||.:...::.:|.|..|||..:     |....||||..:|||.::....|..:.:|:||||
  Rat  1431 ILDALPDVTEHQQKLALAAMRWRKRIQQSRESGIAEGAFSGWKVILRVDRPREAGFKRLLQAGGA 1495

  Fly  1357 CILEPTTPFSKDPVAKSASHCFVDVKK----------APLSTQDM-----EYL 1394
            .:|    |...:|:.|.|:|.|.|..|          |..:.|:|     ||:
  Rat  1496 KVL----PGHPEPLFKDATHLFCDFNKLKPDDCRVFIAEATAQNMVCLKTEYI 1544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mus101	NP_524909.1	BRCT	118..188	CDD:278934	20/69 (29%)
		BRCT	216..290	CDD:278934	19/73 (26%)
		BRCT	397..472	CDD:278934	29/74 (39%)
		BRCT	707..778	CDD:278934	29/78 (37%)
		BRCT	1210..1279	CDD:237994	28/68 (41%)
Topbp1	XP_038938515.1	BRCT_TopBP1_rpt1	183..254	CDD:349369	20/70 (29%)
		BRCT_TopBP1_rpt2_like	273..349	CDD:349363	21/77 (27%)
		BRCT_TopBP1_rpt3	430..511	CDD:349350	31/84 (37%)
		BRCT_TopBP1_rpt4	634..717	CDD:349380	21/98 (21%)
		BRCT_TopBP1_rpt5	726..814	CDD:349387	32/87 (37%)
		BRCT_TopBP1_rpt6	985..1059	CDD:349359	9/73 (12%)
		BRCT_TopBP1_rpt7	1342..1416	CDD:349370	30/79 (38%)
		BRCT_TopBP1_rpt8	1471..1549	CDD:349360	23/78 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	66	1.000	Domainoid score	I9712
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	240	1.000	Inparanoid score	I3263
OMA	1	1.010	-	-		QHG48684
OrthoDB	1	1.010	-	-		D305707at33208
OrthoFinder	1	1.000	-	-		FOG0003632
OrthoInspector	1	1.000	-	-		oto98571
orthoMCL	1	0.900	-	-		OOG6_102493
Panther	1	1.100	-	-	LDO	PTHR13561
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5299
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.980