Protein Alignment mus101 and Topbp1

DIOPT Version :10

• Sequence 1: NP_524909.1
• Gene: mus101 / 48309
• FlyBaseID: FBgn0002878
• Length: 1425
• Species: Drosophila melanogaster
• Sequence 2: XP_063122517.1
• Gene: Topbp1 / 315969
• RGDID: 1562949
• Length: 1519
• Species: Rattus norvegicus
• Alignment Length: 1613
• Identity: 375/1613 - (23%)
• Similarity: 615/1613 - (38%)
• Gaps: 384/1613 - (23%)

  Fly    14 YFVNNLKPGDGG---VQEADTLQQFEAARELLGQQLAETQIRQIKPSEGYPLIAAGNLTKKDVFV 75
            :||..||..|..   .:..:::::.::...|  |.:.:.:..:||.::            |.:::
  Rat     9 FFVKFLKSSDNSECFFKALESIKELQSEEYL--QVITDEEALRIKEND------------KSLYI 59

  Fly    76 LTQFEGEFFEQLQQTRALILGPPCLITCLRRNEPIPEGSSAIYSTAMRDLQVSATGITPQKKEEL 140
            ..:|.|..|:.|:|....|:||..:..|:|..:.:|.....:|:..|.|:.:|.|.:...|:||:
  Rat    60 CDRFSGTAFDHLKQLGCRIVGPQVVTFCMRHQQCVPRAEHPVYNMIMSDITISCTSLDKDKREEV 124

  Fly   141 SRLINWMGGIYFQSFGHRTTHLISNTIKSSKYEQATLNGVPVMHVDWVQYVWDQSRRSQREGIMA 205
            .:.:..|||..::......||||:..:.|.||..|.....|::...|::.:|::|:  :::....
  Rat   125 HKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPAWIKTLWEKSQ--EKKITKY 187

  Fly   206 TDPDFDKYRLPIFFGANITCSGLDVARKDQVMRLVNDNGGIYHRAFRSQVVDIVITEQTKTDTEK 270
            ||.:.:.::.|||.|..|..:||:...:..|.:|...:||.|....:......:|.::.|  .:|
  Rat   188 TDVNMEDFKCPIFLGCIICVTGLNGIHRKTVQQLTAKHGGQYMGQLKMNECTHLIVQEPK--GQK 250

  Fly   271 YKAAIRYKKDVLLPEWIFDSCNRGYALPTKDYEVRPGKTSSTPTKTTRPGAAPG---ADQTHLSD 332
            |:.|.|:....:..:|..||..:|:......|:..|.....|...|:.|.|..|   |:...|:|
  Rat   251 YECARRWNVHCVTLQWFHDSIEKGFCQDESIYKAEPRAAVKTVPDTSTPTAQSGSAAAENHRLAD 315

  Fly   333 LSRISFVSGSRRMCSDLSTVNESVSSVGSSSPAKQLLKQATSSGRNYQQVLAEIEPRQAKKAGAF 397
            :|.||.::||   |     |||::  .||::...:...:      |.:.:  :|...||.:  ..
  Rat   316 VSHISNINGS---C-----VNETM--FGSTTSKLECTLE------NLENL--DISMFQAPE--DL 360

  Fly   398 LDGCCVYLSGFRSEEREKLNRVLNTGGATRYDEANEGISHIIVGQLDDAEYRQWQRDGLMGSVHV 462
            ||||.:||.||...:.:||.|::|:||..|:::.||.::|:|:|..:|...:.|.:..  ...||
  Rat   361 LDGCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIMGDYEDDVRQFWSKSS--HRPHV 423

  Fly   463 VRLDWLLESIRAGRVVSE--LVHRVSMPQNREPDVASPASKRTLRSMNHSFKQPTLPIKKKLFDQ 525
            |...||||....|.::.|  .:|     .|.:|| ..|.|       :....|.|:..|...|.:
  Rat   424 VGAKWLLECFSKGYILPEESYIH-----ANYQPD-GIPVS-------DQPRNQTTVLEKSGTFSK 475

  Fly   526 EPDPVQEQEHEEPDHTLLDQYSQDQGAVAQL-----------PPADVSLLQPAASSTQMDIRQ-- 577
            : |.|..::.::.|..||.||..|...:.:.           |....:.::|...||.:.:::
  Rat   476 K-DFVPNEKFQQTDEDLLAQYVHDDSTIVEAKLSEAIEPEVGPCGGSAHVEPCDDSTHISVQEEN 539

  Fly   578 RVSVAN-----PKPPAEGLQLPDLSASTLSIDFDKLDYFA-GVSVYVHRECFNEEFFNQMLTECE 636
            :.||::     ...|.|||             |.:..:.. |.|  |..||.......:     .
  Rat   540 KSSVSHCLLDGSTVPEEGL-------------FSQKSFLVLGFS--VENECNIVNIIRE-----H 584

  Fly   637 AAQGLLVPSSFSDEVDFAIVSF---EVAFDVKQLPVKARHVVTELFLESCMKKNQLLPIEYYHKH 698
            |.:.:.:||..  ..|:|:|..   ||...|.:       |||..:|.:|:....|:..:.....
  Rat   585 AGKIVSLPSRI--VADYAVVPLLGCEVEATVAE-------VVTNTWLVTCIDNQTLVDPKSNPLF 640

  Fly   699 VPATAL--RQPLKGMTIVVSIYAGLERDFINATAELLGASVNKTFIKKEKPL--------LVCPS 753
            .|.:.:  ..||:...|..|...|.|||.:...|..|||||.:.|::|....        |:...
  Rat   641 TPVSVMSGMTPLEDCVISFSQCVGAERDSLVFLANHLGASVQEFFVRKSNAKKGMLASTHLIVKE 705

  Fly   754 AEGSKYEGAIKWNYPVVTSDWLVQCARTGQKLPFVGYLVGKSPEDFPISPRLRDSNSRTARRPNE 818
            ..|||||.|.||:.|.|...||::.||.|::.....:||..:|:    ..::.::|......||.
  Rat   706 PTGSKYEAAKKWSLPAVNISWLLETARMGKRADENHFLVDSAPK----QEQVLETNIPNGVSPNP 766

  Fly   819 STLVAQPDVTMEEAENQPAGSVTPVTAGSPGAPELTPLRNKRVSELAGIPGGSALHRGSNSTSSP 883
            .: .|.||..: |...|.|               :|||...|..       ..|.|...:..:..
  Rat   767 DS-PAHPDAHL-EIHRQKA---------------VTPLDMNRFQ-------SKAFHAVISQHNRQ 807

  Fly   884 DSPCTPLSQVGAQQ--YNLDFLEQFVQR----------------LDTEEGKDCVREIIREMRE-- 928
            .....|:.|...::  ::||...:|:.:                |:|.......|::...:.|
  Rat   808 GLASPPVRQPPKKEPSFHLDTPSKFLSKDKLFKPSFDVTDALAALETPNAASQKRKLSSPLSEVI 872

  Fly   929 --NQTPEL-ERIRRQACTPVS--------RKHQRPAP--------------------GIP----- 957
              |.|..| ...|...|...|        .|.:.|.|                    |:.
  Rat   873 VRNLTTALANSSRNTGCLSASPQLKGAHLEKEETPKPLDKVVVCVSKRLSKKQSELNGVAASLGA 937

  Fly   958 ------DFCLTPEFQQRMADDFER---------------RWRL-------------------PTM 982
                  |..:|....|..|:|..|               .|.|                   |.|
  Rat   938 EYRWSFDETVTHYIYQGRANDSNREYKSAKERGVHVVSEHWLLECAQEYKHLPESLYPHTYNPKM 1002

  Fly   983 KIKPDT-----------PLAVIRQR--------VMRITCETLGIEYEES------------NAKT 1016
            .:...|           |.|:...:        |.....||||....||            .|.|
  Rat  1003 SLDISTVQDGRLCDSRLPSALSASKDDEPDHLSVEENATETLGTHSRESALLNGNGRDDCKGALT 1067

  Fly  1017 PTLSESPSTVKK-----------KPPTRTTQATKLNFDRSPKTPKLSLGKKTPLRVSMGSPRSGT 1070
            ..|....:..|:           :.|.:.|..::.:.:.:..||.           |..|.|||.
  Rat  1068 QALEMRENFQKQLQEIMSATSIVRTPAQKTCMSRSSCNSASSTPD-----------STRSARSGR 1121

  Fly  1071 QSPFVPNTQS-----PIEAAPPRRS----DGPTLSEE-----------------GQSTINFDKIS 1109
            ........||     .|...|.:..    |.||..||                 .:..:...|:.
  Rat  1122 SRVLEALRQSRQIVPDINTEPSQNEQIIWDDPTAREERARLASNLQWPSYPTQYSELQVEIKKLD 1186

  Fly  1110 FEESAVPVLAPDVPTVAPDVKQITDYLKNCE------SRRNSLKRSHDNDMDCGESEVQYVQ-PF 1167
            ...|..||...::...|..|.|........|      :.||.:.          |.:...|. |.
  Rat  1187 DSPSRKPVYHSEIAGQASCVTQAPGQHPGSEEPEAPAAERNLIP----------EPQAPSVAFPL 1241

  Fly  1168 ESEGFALGTEDMVDWRDPAEFNAAKRRSSGGSPKMQYAGIPCFSISCGDDDEKRAELIARITQLG 1232
            .....|...||.::..:          .:.|..|.||.    |.:|..:..| |.:....|..||
  Rat  1242 AKPPVAPQPEDKIETLE----------ETHGKLKKQYV----FQMSSLNSQE-RIDYCRLIKDLG 1291

  Fly  1233 GKVCENLVNYDDSCTHLLCERPNRGEKMLACIAAGKWILNIQYIEQSHARGDFLDETLYEWGNPK 1297
            |.|.|...: |.||||::...|.|.||.||.:|||||:|:..|::.....|.|:.|..||||:..
  Rat  1292 GSVIEKQCS-DPSCTHMVVGYPLRNEKYLASMAAGKWVLHRSYLDACRTAGRFVQEEDYEWGSSS 1355

  Fly  1298 AIN-LPTLAPEEEPIAAAVHRWRTEL-----SACGGGAFSDHRVILSMNERSGAPIRNVLRAGGA 1356
            .:: ||.:...::.:|.|..|||..:     |....||||..:|||.::....|..:.:|:||||
  Rat  1356 ILDALPDVTEHQQKLALAAMRWRKRIQQSRESGIAEGAFSGWKVILRVDRPREAGFKRLLQAGGA 1420

  Fly  1357 CILEPTTPFSKDPVAKSASHCFVDVKK----------APLSTQDM-----EYL 1394
            .:|    |...:|:.|.|:|.|.|..|          |..:.|:|     ||:
  Rat  1421 KVL----PGHPEPLFKDATHLFCDFNKLKPDDCRVFIAEATAQNMVCLKTEYI 1469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mus101	NP_524909.1	BRCT	127..189	CDD:349339	18/61 (30%)
		BRCT_TopBP1_rpt2_like	216..294	CDD:349363	21/77 (27%)
		BRCT_TopBP1_rpt3	392..476	CDD:349350	29/83 (35%)
		BRCT	707..786	CDD:469589	32/86 (37%)
		BRCT_TopBP1_rpt7	1208..1283	CDD:349370	28/74 (38%)
		BRCT	1334..1414	CDD:469589	23/76 (30%)
Topbp1	XP_063122517.1	None