DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mus101 and rad4

DIOPT Version :9

Sequence 1:	NP_524909.1	Gene:	mus101 / 48309	FlyBaseID:	FBgn0002878	Length:	1425	Species:	Drosophila melanogaster
Sequence 2:	NP_593190.1	Gene:	rad4 / 2543281	PomBaseID:	SPAC23C4.18c	Length:	648	Species:	Schizosaccharomyces pombe

Alignment Length:	810	Identity:	145/810 - (17%)
Similarity:	264/810 - (32%)	Gaps:	274/810 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 GANITCSGLDVARKDQVMRLVNDNGGIYHRAFRSQVVDIVITEQTKTDTEKYKAAIRYKKD--VL 282
            |..|.|:.:|:.::.::.......|..|...|...|..::..:   .||.|||.|.:.:.|  ::
pombe     9 GFVICCTSIDLKQRTEISTKATKLGAAYRSDFTKDVTHLIAGD---FDTPKYKFAAKSRPDIKIM 70

  Fly   283 LPEWIFDSCNRGYALPTKDYEVRPGKTSSTPTKTTRPGAAPGADQTHLSDLSRISFVSGSRRMCS 347
            ..|||          |.. ||                                 |:|.|     .
pombe    71 SSEWI----------PVL-YE---------------------------------SWVQG-----E 86

  Fly   348 DLSTVNESVSSVGSSSPAKQLLKQATSSGRNYQQVLAEIEPRQAKKAGAFLD--------GCCVY 404
            ||..                                           |..:|        .|.|.
pombe    87 DLDD-------------------------------------------GLLVDKHFLPTLFKCRVC 108

  Fly   405 LSGFRSEEREKL-NRVLNTGGATRYDEANEGISHIIVGQLDDAEYR---QWQRDGLMGSVHVVRL 465
            |:.....||.:: |.||..|| |...:....::|:|.|.....:|.   :|:       ::||.:
pombe   109 LTNIGQPERSRIENYVLKHGG-TFCPDLTRDVTHLIAGTSSGRKYEYALKWK-------INVVCV 165

  Fly   466 DWLLESIRAGRVVSELVHRVSMPQNR---------EPDV--ASPASKRTLRSMNHSFKQPTLPIK 519
            :||.:||:...|:.....::.||..:         :|:.  |...|:....|.|......:|...
pombe   166 EWLWQSIQRNAVLEPQYFQLDMPAEKIGLGAYVRLDPNTTEAKSYSENQKISKNKEKSGQSLAAL 230

  Fly   520 KKLFDQEP--------------------DPVQEQEHEEPDHTLLDQYSQDQGAVAQLPPADVSLL 564
            .:..|.||                    ...:.....|.:..|||.::          |..|..|
pombe   231 AEEADLEPVIMKRGKKRDRSILWEELNNGKFEFSSRSEENSVLLDDFT----------PETVQPL 285

  Fly   565 QPAASSTQMDIRQRVSVANPKPPAEGLQLPDLSASTLSIDFDKLDYFAGVSVYVHRECFNEEFFN 629
            :.....|:::|.....:                             |..::.|::      ||.|
pombe   286 EENELDTELNIENEAKL-----------------------------FKNLTFYLY------EFPN 315

  Fly   630 ---QMLTECEAAQGLLVPSSFSDEVDFAIVSFEVAFDVKQLPVKARHVVTELFLESCMKKNQLLP 691
               ..|.:|.:..|..:....|..:||.::..  .|.|.:||:.:...|.|.::|.|:...::..
pombe   316 TKVSRLHKCLSDNGGQISEFLSSTIDFVVIPH--YFPVDELPIFSFPTVNEWWIERCLYYKKIFG 378

  Fly   692 IEYYHKHVPATALRQP-----LKGMTIVVSIYAGLERDFINATAELLGASVNKTFIKKEKPLLVC 751
            |:   :|..|....:|     ..|::|.::.:.|.|...:.....:|||.|:: |:..::.:|:.
pombe   379 ID---EHALAKPFFRPSLVPYFNGLSIHLTGFKGEELSHLKKALTILGAVVHE-FLGVQRSILLV 439

  Fly   752 PSAE------GSKYEGAIKWNYPVVTSDWLVQCARTGQKLPFVGYLVGKSPEDFPISPRLRD--S 808
            .:.|      ..|.:.|.:||..||...||....::|:   |:.          .:||...|  .
pombe   440 NTNEPFSMKTRFKIQHATEWNVRVVGVAWLWNIIQSGK---FID----------QVSPWAIDKKE 491

  Fly   809 NSRTARRPNESTLV---AQPDVTMEEA-ENQPAGSVTPVTAGSPGAPELTPLRNKRVSELAG--- 866
            |....:..|::.:|   :..|..::.: ..||.|..||     ..:|.|..::.::.:.:..
pombe   492 NQEIKKFTNQNNMVFPTSDRDTRLQNSLAQQPIGHSTP-----HNSPSLLSVKKRQNNHIRSNTL 551

  Fly   867 -------------------IPGGSALHRGSNSTSSPDSPCTPLSQVG-----AQQYNLDFLEQFV 907
                               :||........:|.:.|::|.:|...|.     ||:.......|..
pombe   552 IQLNSNSKDSTIFPRRSVTVPGDKIDTVWKSSVTKPETPTSPQEHVSYIDPDAQREKHKLYAQLT 616

  Fly   908 QRLDT----------EEGKDCVREIIREMR 927
            ..:|.          |.|...:.|..|::|
pombe   617 SNVDAIPPANDLQNQENGLLLITESHRKLR 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mus101	NP_524909.1	BRCT	118..188	CDD:278934
		BRCT	216..290	CDD:278934	18/71 (25%)
		BRCT	397..472	CDD:278934	21/86 (24%)
		BRCT	707..778	CDD:278934	20/81 (25%)
		BRCT	1210..1279	CDD:237994
rad4	NP_593190.1	BRCT	4..75	CDD:214602	16/68 (24%)
		PTCB-BRCT	105..167	CDD:289507	18/69 (26%)
		BRCT	301..371	CDD:214602	18/106 (17%)
		BRCT	395..473	CDD:278934	19/78 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1929
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003632
OrthoInspector	1	1.000	-	-		otm47399
orthoMCL	1	0.900	-	-		OOG6_102493
Panther	1	1.100	-	-	LDO	PTHR13561
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1061
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.930