Protein Alignment mus101 and rgf1

DIOPT Version :10

• Sequence 1: NP_524909.1
• Gene: mus101 / 48309
• FlyBaseID: FBgn0002878
• Length: 1425
• Species: Drosophila melanogaster
• Sequence 2: NP_588116.1
• Gene: rgf1 / 2539580
• PomBaseID: SPCC645.07
• Length: 1334
• Species: Schizosaccharomyces pombe
• Alignment Length: 960
• Identity: 191/960 - (19%)
• Similarity: 304/960 - (31%)
• Gaps: 298/960 - (31%)

  Fly   297 LPTKDYEVRPGKTSSTPTKTTRPGAAPGADQTHLSDLSRISFVSGSRRMCSDLSTVNESVSSVGS 361
            ||.|....|  .||..|     |.:.|.|..||..:.|.:..:..|           ||..||..
pombe    57 LPRKPLPFR--STSLQP-----PSSQPPAPPTHQREASPVKNIEHS-----------ESFPSVFG 103

  Fly   362 SSPAKQLLKQATSSGRNYQQVLAEIE-----PRQAKKAGAFLDGCCVYLSGFRSEEREKLNRVLN 421
            :|...|::......|.::..:.|.:.     |:.:..|.             .:.....|....:
pombe   104 TSNNHQIVPLTLKDGNDFGALYASLNTTPHFPQVSNHAP-------------NNSNSPSLTWHTS 155

  Fly   422 TGGATRYDEANEGISHIIVGQLDDAEYRQWQR----------DGLMGSVHVVRLDWLLESIRAGR 476
            :|     |::|:....:         .||.|.          :.|:.:|..|     .||:..
pombe   156 SG-----DDSNQNPFFV---------RRQSQSSTSPVSDSVDENLLSAVSSV-----TESVET-- 199

  Fly   477 VVSELVHRVSMPQNREPDVASPASKRTLRSMNHSFKQPTLPIKKKLFDQEPDPVQEQEHEEPDHT 541
                   .:.:.||.  ...||.         .|.|.|.|....:|      |..:..|....|:
pombe   200 -------NLHLDQNY--PYGSPV---------RSSKNPFLSSNSRL------PTDDSSHTVGSHS 240

  Fly   542 LLDQYSQ---DQGAVAQLPPADVSLLQPAASSTQMDIRQRVS--VANPKPPAEGLQLP------- 594
            .......   ...:...||.|    :.|||   |..:.:.||  .||..|||:.||||
pombe   241 FTSGTHPPIVSSNSAFTLPNA----VTPAA---QAPLIRSVSEYPANVSPPAQSLQLPKSTSNPA 298

  Fly   595 DLSASTLSIDFDKLDYFAGVSVYVH-------------RECFNEEFFNQMLTECEAA--QGLLV- 643
            ||..|..|....| :.|:|:.|:.:             .:..|..|.:..|...||.  |.|.|
pombe   299 DLHLSIASASSHK-NIFSGLDVFSNVFHGPSTTLRDREHDMRNRSFDHSTLAHYEAVKQQRLGVE 362

  Fly   644 PSSFSDEVDFAIVSFEVAFDVKQLPVKARHVVTELFLESCMKKNQLLPIEYYHKHVPATALRQPL 708
            |::.|    |.:.|::.......|........|..|:.|    ....|:   ||:....
pombe   363 PTARS----FTLSSYKSRASGNSLINDRSSTTTPTFVNS----EASSPV---HKNKRRR------ 410

  Fly   709 KGMTIVVSIYAGLERDFINATAELLGASVNKTFIKKEKPLLVCPSAEGSKYEGAIKWNYPVVTSD 773
                   .|||.|   .....:|||           ::..|...:.:|..|..|...::.|....
pombe   411 -------RIYAAL---LSRVASELL-----------DRLQLGDITKDGLIYSNAFTGDHAVTVLM 454

  Fly   774 WLVQCARTGQKLPFVGYLVGKSPE------DFPISPRLRDSNSR------TARRP----NESTLV 822
            .::..:.....|     |||:|.:      |.....|||||:..      |..||    |::..:
pombe   455 GIIHTSDRNLAL-----LVGRSLDAQKFIHDVTYDHRLRDSHREIYQLQGTGYRPFLRANDNASI 514

  Fly   823 AQPDVTMEEAENQPAGSVTPVTAGSPGAPELTPLRNKRVSELAGIPGGSALHRGSNSTSSPDSPC 887
            ...:...|..:|:....::|.|.|....|.             ||  .:.|....:.|.:.|.||
pombe   515 NNKNHHKELEDNESGTRISPSTLGDTSFPN-------------GI--FTLLTHCYSPTCAKDHPC 564

  Fly   888 TPLS--QVGAQQYNLDFLEQFVQRLDTE----------EGKDCVREIIREMRENQTPELERIRRQ 940
            ..:|  :...||:.| |.:   .|.:||          |.|..:..:.:|:..: ..:.||.|::
pombe   565 YSISCPRRLEQQHRL-FAK---MRANTEQSSSLAFDDKEQKLWIHSVPQEIAYS-VSDRERKRQE 624

  Fly   941 ACTPV---SRKHQRPAPGIPDFCLTPEF-----QQRMADDFERRWRLPTMKIKP-DTPLA---VI 993
            ....|   .|...:....:.|:.:.|.:     .:|..:.|.|...|..::::. ::.||   ..
pombe   625 VICEVIYTERDFVKDLEYLRDYWIKPLWASSCIPERKKEKFIRTVFLNALEVQAVNSKLAEALTK 689

  Fly   994 RQRVMRITCETLGI-----------------------EYEESNAKTPTLSESPSTVKK------- 1028
            ||....|......|                       |:|:..:..|..::..|.|::
pombe   690 RQNYKPIVDNIADIFLEHVPKFEPFIRYGAGQLYGKYEFEKEKSSNPAFAKFVSDVERLKESRKL 754

  Fly  1029 -------KPPTRTTQATKL-----------NFDRS--PKTPKLSLGKKTPLRVSMGSPRS----- 1068
                   ||.||..:...|           |.|:.  ||...:..|..:.|.|..|...:
pombe   755 ELNGYLTKPTTRLARYPLLLEAVLKYTDEGNPDKQDIPKVINIVRGFLSRLNVESGKAENKFNLF 819

  Fly  1069 --GTQSPFVP-----------NTQSPIEAAPPRRSDGPTLSEEGQSTINF 1105
              ..|..|.|           |.|...:....:||.|.|.||.......|
pombe   820 HLNQQLVFKPGEHYDLHLLDANRQLIFKGPLKKRSAGSTSSESASDVTLF 869

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mus101	NP_524909.1	BRCT	127..189	CDD:349339
		BRCT_TopBP1_rpt2_like	216..294	CDD:349363
		BRCT_TopBP1_rpt3	392..476	CDD:349350	13/93 (14%)
		BRCT	707..786	CDD:469589	12/78 (15%)
		BRCT_TopBP1_rpt7	1208..1283	CDD:349370
		BRCT	1334..1414	CDD:469589
rgf1	NP_588116.1	ROM1	6..1320	CDD:227709	191/960 (20%)