DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mus101 and rgf3

DIOPT Version :9

Sequence 1:	NP_524909.1	Gene:	mus101 / 48309	FlyBaseID:	FBgn0002878	Length:	1425	Species:	Drosophila melanogaster
Sequence 2:	NP_588115.1	Gene:	rgf3 / 2539437	PomBaseID:	SPCC645.06c	Length:	1275	Species:	Schizosaccharomyces pombe

Alignment Length:	268	Identity:	64/268 - (23%)
Similarity:	88/268 - (32%)	Gaps:	77/268 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   786 PFVGYLVGKSPEDFPISPRLRDSNSRTARRPNESTLVAQPD-VTMEEAENQPAGSVTPVTAGS-P 848
            ||:......||..|..||....: |..:||....|:.:.|. .|..:..|:|..|....|..| |
pombe    58 PFLSKRSNNSPHRFSYSPPQHPA-SINSRRVASYTVQSSPSRTTYRQLPNEPQNSAAYTTYSSFP 121

  Fly   849 GA--------------PELTPLRNKR--------VSELAGIPGGSALH-----RGSNSTSSPDSP 886
            .|              |.||...||:        :.|....||||.:|     ...:|.||..||
pombe   122 NALFDDFSPNNPLDTDPFLTSPGNKQNTVDSFRPLPETPVSPGGSLVHPLPRPPLPSSVSSHSSP 186

  Fly   887 CTPLSQVGAQQYNLDFLEQFVQRLDTEEGKDCVREIIREMRENQTPE----LERIRRQACTP--- 944
            .:..|....  |:|                      ..::..:.:||    |...|..|.||
pombe   187 YSTTSSTSL--YSL----------------------YNDISLSCSPEPYLPLSPTRSPARTPSPI 227

  Fly   945 --VSRKHQRP----APGIPDFCLTPEFQQRMADDFERRWRLPTMKI------KPDTPLAVIRQRV 997
              .|....||    :|.:.  .|||.....:..|.....:||.:.:      |..:||.....|
pombe   228 RLYSSDALRPQSPLSPSVE--YLTPPNPYSLKSDISSTRQLPKIPVQDYASGKISSPLITRTHR- 289

  Fly   998 MRITCETL 1005
             |...|||
pombe   290 -RAQSETL 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
mus101	NP_524909.1	BRCT	118..188	CDD:278934
		BRCT	216..290	CDD:278934
		BRCT	397..472	CDD:278934
		BRCT	707..778	CDD:278934
		BRCT	1210..1279	CDD:237994
rgf3	NP_588115.1	RhoGEF	470..656	CDD:279015
		PH-like	695..850	CDD:302622
		CNH	939..1236	CDD:279162
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47399
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000