Protein Alignment mus101 and topbp1

DIOPT Version :9

• Sequence 1: NP_524909.1
• Gene: mus101 / 48309
• FlyBaseID: FBgn0002878
• Length: 1425
• Species: Drosophila melanogaster
• Sequence 2: XP_002937791.3
• Gene: topbp1 / 100380063
• XenbaseID: XB-GENE-990637
• Length: 1515
• Species: Xenopus tropicalis
• Alignment Length: 1653
• Identity: 398/1653 - (24%)
• Similarity: 645/1653 - (39%)
• Gaps: 402/1653 - (24%)

  Fly     3 ISMSMDETICAYFVNNLKPGDGGVQEADTLQQFEAARELLGQQLAETQIRQIKPSEGYPLIAAGN 67
            ::.|.:|..|..|:.:.:..:...:..:.::|.::...|  |...|::...:|..:
 Frog     1 MARSENEPFCVKFIKSPENSEYFFKAYEAIKQIQSDESL--QLTEESEALLLKEKD--------- 54

  Fly    68 LTKKDVFVLTQFEGEFFEQLQQTRALILGPPCLITCLRRNEPIPEGSSAIYSTAMRDLQVSATGI 132
               |.:::...|.|..|..|::....|:||..:|.|:.....:|.....:|:.||.|:.:|.|.:
 Frog    55 ---KSLYICDPFSGAVFNHLKKLGCRIVGPQVVIFCMEHQRRVPRAEYPVYNMAMADVTISCTSL 116

  Fly   133 TPQKKEELSRLINWMGGIYFQSFGHRTTHLISNTIKSSKYEQATLNGVPVMHVDWVQYVWDQSRR 197
            ..:.:|::...:..|||..::......||||:..:.|.||..|.....|::...||:.:|||
 Frog   117 DKETREDVHNYVQLMGGCVYRDLNVSVTHLIAGEVGSKKYLVAASLEKPILLPSWVKALWDQ--- 178

  Fly   198 SQREGIMATDPDFDKYRLPIFFGANITCSGLDVARKDQVMRLVNDNGGIYHRAFRSQVVDIVITE 262
            |.::.|...|.:..:|..|||.|..|..:||:...:.:|.||...:||.|....:......:|.:
 Frog   179 SNQQIIRYCDVNMKEYLCPIFRGCTICVTGLNSLDRKEVQRLTTLHGGEYTGQLKMNESTHLIVQ 243

  Fly   263 QTKTDTEKYKAAIRYKKDVLLPEWIFDSCNRGYALPTKDYEVRPGKT-SSTPTKTTRPGAAPGAD 326
            :.|  .:||:.|.::....:..:|.|||.::|:......|::.|..: .|.|..:|..|.....|
 Frog   244 EAK--GQKYECARKWNVHCVSVQWFFDSLDKGFCQDETMYKIEPATSLKSVPDTSTPTGDNKKPD 306

  Fly   327 QTHLSDLSRISFVSGSRRMCSDLSTVNESV-SSVGSS--SPAKQLLKQATSSGRNYQQVLAEIEP 388
            ...:.|:|:||.:|        .|.||||. :||.:|  .|....|:.            .:|..
 Frog   307 SRAIYDVSQISNIS--------TSCVNESAFNSVMTSRLDPPADALEN------------LDISS 351

  Fly   389 RQAKKAGAFLDGCCVYLSGFRSEEREKLNRVLNTGGATRYDEANEGISHIIVGQLDDAEYRQWQR 453
            .||.:  ..||||.:||.||...:.:||.|::|:||..|:.:....::|||||:.|: |.:|:
 Frog   352 LQAPE--DLLDGCRIYLCGFGGRKLDKLRRLINSGGGVRFSQLTADVTHIIVGETDE-ELKQF-- 411

  Fly   454 DGLMGSVH---VVRLDWLLESIRAGRVVSELVHRVSMPQNREPDVASPASKRTLRSMNHSFKQPT 515
              |..:.|   |:.:.|||||...|.:..|.::..|..|..|  ::||.             ||.
 Frog   412 --LSKTQHRPYVLTVKWLLESFSKGHLQPENIYSHSSYQQTE--LSSPV-------------QPA 459

  Fly   516 LPIKKKLFDQEPDPVQEQEHEEPDHTLLDQYSQDQGAVAQLPPADVSLLQPAASSTQMDIRQRVS 580
            ..:..:.......|:....:::.|..||.||:::...:.:                  |...::|
 Frog   460 FNLTAQKISSTRGPLNHTHNQQADEDLLSQYTENNSTLIE------------------DEHPKIS 506

  Fly   581 VANPKPPAEGLQLPDLSASTLSIDFDKLDY-----FAGVSVYVHRECFNEEFFNQM--LTECEAA 638
            ..|             |.|.:|:..|....     .|..|..:....|:.:.|..:  |.|.||.
 Frog   507 NTN-------------SISQMSMHEDMTSCTSQSGLADTSTIIEGGLFSRKQFLVLGFLEEDEAC 558

  Fly   639 --------QGLLVPSSFSDEVDFAIVSF---EVAFDVKQLPVKARHVVTELFLESCMKKNQLL-P 691
                    .|.::.|......|:|:|..   ||...|.:       |||..:|..|:::.:|| |
 Frog   559 IIDIIKKNAGKVLSSQKRAIADYAVVPLLGCEVESTVGE-------VVTNAWLGMCIEQEKLLDP 616

  Fly   692 IEYYHKH-----VPATALRQPLKGMTIVVSIYAGLERDFINATAELLGASVNKTFIKKEKPL--- 748
                |.:     ||.....:||:...:.||.:.|.|||.:...|.||||.|.:.|::|..|.
 Frog   617 ----HSNALFTPVPCLEGSRPLQECVLSVSQFMGAERDSLVYLAGLLGAKVQEFFVRKANPKKDM 677

  Fly   749 -----LVCPSAEGSKYEGAIKWNYPVVTSDWLVQCARTGQKLPFVGYLVGKSPEDF--------- 799
                 ||...|||||||.|.|||.|.||..||:||||||:|.....|||...||:.
 Frog   678 FASTHLVLKDAEGSKYEAAKKWNLPAVTMKWLLQCARTGKKADEHHYLVDSVPEEDESFISQTYK 742

  Fly   800 -PISPRLRDSNSRTARRPNESTLVAQPDVTMEEAENQPAGSV------TPVTAGSPG-----APE 852
             .:|.|..|:.......|......|...:.|...:::...||      .|.|.|...     .|.
 Frog   743 PQVSRRSMDAPCHQENHPQALKKAAVTPLDMNRFQSKAFQSVISQHNKNPQTPGGESKVLQREPS 807

  Fly   853 L---TPLRNKRVSE-------------LAGI--PGGSALHRGSNSTSSPDSPCTPLSQVGAQQYN 899
            |   ||  :|.:|:             ||.:  ||      |.|..|...|  ||||:|..:...
 Frog   808 LHLDTP--SKFLSKDKLFKPSFDVKDALAALETPG------GPNQKSRTQS--TPLSEVIGRNLQ 862

  Fly   900 LDFLEQFVQ--------RLDTEEGKD-------------CV-REIIREMRE-------------- 928
            |.......|        :|...|.|:             || :::|::..|
 Frog   863 LAIANSTRQTAAVTASPQLKAAEQKEQLENSKVLHNVVICVSKKLIKKQGELNGIAASLGAEYRW 927

  Fly   929 ----------------NQTPELERIRRQ------------ACTPVSRKHQRPAPGIPDFCLTPEF 965
                            :.:.|.:.::.:            ||:...::       :|:......:
 Frog   928 CFDESVTHFIYHGRQNDMSREYKSVKERSGICIVSEHWLLACSEQQKR-------VPEALYPHTY 985

  Fly   966 QQRMADDFE--RRWRLPTMKIKPDTPLAVIRQRVMRI-TCETLG------IEYEESN-------- 1013
            ..:|:.|..  :.......|...||.|.:.....:|: ..:.||      ::.|..|
 Frog   986 NPKMSLDISGVQDGSHTASKFSADTSLQLDENCELRLQQNDELGETSDDQVKKEADNRDPQNPLK 1050

  Fly  1014 ----AKTPTLS-------------ESPSTVKKKPPTRTTQATKLNFDRSPKTPKLSLGKKTPLRV 1061
                |.|.||.             .:.|.||.:.|..:  .|::.||.||.||:.:...:.....
 Frog  1051 EVKGALTQTLEMRENFQRQLQELMSATSVVKPQGPRGS--LTRVGFDNSPCTPEGARSTRNGRSR 1113

  Fly  1062 SMGSPRSGTQSPFVPNTQSPIEAAPPRRS----DGPTLSEEGQSTINFDKISFEESAVPVLAPDV 1122
            .:.:.|...|:....||:      |.:..    |.||..||....::           .:..||.
 Frog  1114 VLEALRQSRQATTDLNTE------PSQNEQIIWDDPTAREERAKLVS-----------NLQWPDS 1161

  Fly  1123 PTVAPD---------------VKQ-ITD----YLKNCESRRNSLKRS--HDNDMDCGESEVQYVQ 1165
            |:...:               ||: :||    .|:.||....|:.|:  .:||:. ..:::..:.
 Frog  1162 PSQYSEQLQLNMTDAGGNYAAVKESLTDTEIAELEACEFEHKSVTRAPMTENDLQ-SPNKLDQLT 1225

  Fly  1166 P---FESEGFALGTEDMVDWRDPAE-----FNAAK----RRSSGGSPKMQYAGIPCFSISCGDDD 1218
            |   ..|..|.|....:..  .|.|     |:..|    ||               |.:|..|..
 Frog  1226 PTPQAPSIAFPLANPPVAP--QPKEKPVKPFSEEKTIKERR---------------FQLSSLDPQ 1273

  Fly  1219 EKRAELIARITQLGGKVCENLVNYDDSCTHLLCERPNRGEKMLACIAAGKWILNIQYIEQSHARG 1283
            | |.:....|.::||.|.|... :|.||||::...|.|.||.||.:|||||:|:..|:|...|..
 Frog  1274 E-RIDYSQLIEEIGGVVIEKQC-FDPSCTHIIVGHPLRNEKYLASMAAGKWVLHRSYLEACRAAK 1336

  Fly  1284 DFLDETLYEWGNPKAINLPT-LAPEEEPIAAAVHRWRTELS------ACGGGAFSDHRVILSMNE 1341
            .|:.|..||||:...::..| :.|::..:|.|..|||.:|.      ....||||..:|||::::
 Frog  1337 QFIQEDDYEWGSKSILSAVTNINPQQRMLAEAAMRWRKKLQGIKQNMGIAEGAFSGWKVILNVDQ 1401

  Fly  1342 RSGAPIRNVLRAGGACILEPTTPFSKDPVAKSASHCFVDVKK----------APLSTQDMEYLHK 1396
            ......:.:|::|||.:...    ....:.|.|:|.|.|..|          |..:.|
 Frog  1402 TKEPGFKRLLQSGGAKVFAG----HSSALFKEANHLFADFSKLKPDEPKVNVAEAAAQ------- 1455

  Fly  1397 CGVQVLSQIAINAYLMNGRDADLGKYQL 1424
             ||..|....|..|||......:..|.|
 Frog  1456 -GVNCLKPEYIADYLMKEPPPPVNNYCL 1482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mus101	NP_524909.1	BRCT	118..188	CDD:278934	19/69 (28%)
		BRCT	216..290	CDD:278934	20/73 (27%)
		BRCT	397..472	CDD:278934	30/77 (39%)
		BRCT	707..778	CDD:278934	35/78 (45%)
		BRCT	1210..1279	CDD:237994	29/68 (43%)
topbp1	XP_002937791.3	BRCT_TopBP1_rpt1	108..179	CDD:349369	21/73 (29%)
		BRCT_TopBP1_rpt2_like	197..273	CDD:349363	22/77 (29%)
		BRCT_TopBP1_rpt3	353..435	CDD:349350	33/88 (38%)
		BRCT_TopBP1_rpt4	541..624	CDD:349380	23/93 (25%)
		BRCT_TopBP1_rpt5	633..721	CDD:349387	42/87 (48%)
		BRCT_TopBP1_rpt6	896..971	CDD:349359	7/74 (9%)
		BRCT_TopBP1_rpt7	1263..1336	CDD:349370	32/89 (36%)
		BRCT_TopBP1_rpt8	1392..1472	CDD:349360	22/91 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10489
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	356	1.000	Inparanoid score	I2184
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D305707at33208
OrthoFinder	1	1.000	-	-		FOG0003632
OrthoInspector	1	1.000	-	-		otm49376
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5299
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.060