Protein Alignment mus101 and ect2

DIOPT Version :10

• Sequence 1: NP_524909.1
• Gene: mus101 / 48309
• FlyBaseID: FBgn0002878
• Length: 1425
• Species: Drosophila melanogaster
• Sequence 2: XP_012818117.1
• Gene: ect2 / 100127840
• XenbaseID: XB-GENE-998093
• Length: 985
• Species: Xenopus tropicalis
• Alignment Length: 1077
• Identity: 204/1077 - (18%)
• Similarity: 338/1077 - (31%)
• Gaps: 365/1077 - (33%)

  Fly    36 EAARELLGQQLAETQIRQ--IKPSEGYPLIAAGNLTKKDVFVLTQFEGEFFEQLQQTRALILGPP 98
            |.:||...:.:...:|:.  ||.......:.|.....:.|||::.|:...:..|.:....:||||
 Frog    87 EKSRESFIKSIVNMEIKVPCIKTDSVEEFVEADTPEFESVFVISDFQKPAYRFLYKADCRVLGPP 151

  Fly    99 CLITCLRRNEPIPEGSSAIYSTAMRDLQVSATGITPQKKEELSR---LINWMGGIYFQSFGHRTT 160
            .:|.|.::.||:|..|..:|..:|.:|.:..||.  :|||||.:   |::.|||...:.|..:.|
 Frog   152 IIIYCAQKGEPLPFTSRPLYCASMLNLVLCFTGF--RKKEELVKLVTLVHHMGGTIRKDFSSKVT 214

  Fly   161 HLISNTIKSSKYEQATLNGVPVMHVDWVQYVWDQSRRSQREGIMATDPDF-DKYRLPIFFGANIT 224
            |||:|:....|:..|...|.|:|..||:...|:  :|::.| ..||:.:| .|:::|.|....::
 Frog   215 HLIANSTHGDKFRVAVSLGTPIMKADWIIQAWE--KRNELE-FSATNEEFKSKFKVPPFQDCILS 276

  Fly   225 CSGLDVARKDQVMRLVNDNGGIYHRAFRSQVVDIVITEQTKTDT--EKYKAAIRYKKDVLLPEWI 287
            ..|.....:..:..:....||.:......:...:|:.|.:..:.  |..|     |..|:..||.
 Frog   277 FLGFSDEDRVSMEEMTEMQGGTFLSVGDEKCTHLVVEENSVKELPFEPPK-----KLYVVKQEWF 336

  Fly   288 FDSCNRGYALPTKDYEVRPGKTS--------------------STPTKTTR-------------- 318
            :.|.         ..:.|.|:|.                    :||:...:
 Frog   337 WGSI---------QMDARAGETMYLFEKNDSPALKKSVSLLSLNTPSSNRKKRRLKDTLAQLTRE 392

  Fly   319 -------PGAAPGADQT-HLSDLSRISFVSGSRRMCSDLSTVNESVSSVGSSSPAK----QLLKQ 371
                   |...|.|:.: .:..|..||....|.:..||...:::. |.:.:..|.:    |:..:
 Frog   393 TDLTPFPPRKRPSAEHSLSIGSLLDISNTPESGKSFSDTPKISKP-SKISTPVPQQSARWQVAME 456

  Fly   372 ATSSGRNYQQVLAEIEPRQAKKAGAFLDGCCVYLSGFRSEEREKLNRVLNTGGATRYDEANEGIS 436
            ...:..||..:|..|                |.|.....|:..:|      ||.....|..:.|.
 Frog   457 LYQTESNYVDILTTI----------------VQLFQLPLEKEGQL------GGPILAPEEIKTIF 499

  Fly   437 HIIVGQLDDAEYRQWQRDGLMGSVHVVRLDWLLESIRAGRVV----------------------- 478
            ..|...||       ....:.|.:..:.:|| .||...|.::
 Frog   500 GSIPDILD-------VHTNIKGDLEKLMIDW-AESKSIGDIILTYSKDLVKIYPPFVNFFEMSKE 556

  Fly   479 ---------------------------SELVHRVSMPQNREPDVASPASKRTLRSMNHSFKQPTL 516
                                       ..||..:..|..|.|.||...:
 Frog   557 MIIKCEKQKPRFHAFLKINQSKPECGRQTLVELLIRPVQRLPSVALLLN---------------- 605

  Fly   517 PIKKKLFDQEPDPVQEQE----------HEEPDHTLLDQYSQDQGAVAQLPPADVSLLQPAASST 571
            .:||...|..||.|..::          |...|....:...|....|.::.....:||     |:
 Frog   606 DLKKHTADDNPDKVMLEKAIESLKEVMMHINEDKRKTEGQKQIFDVVYEVDGCPANLL-----SS 665

  Fly   572 QMDIRQRVSVANPKPPAEGLQLPDLSASTLSIDFDKLDYFAGVSVYVHRECFNEEFFNQMLTECE 636
            ...:.|||                   .|:::..|..|....|::::..:|
 Frog   666 HRILVQRV-------------------ETIALGEDLCDRGEQVTLFLFNDC-------------- 697

  Fly   637 AAQGLLVPSSFSDEVDFAIVSFEVAFDVKQLPVKARHVVTELFL-------ESCMKKNQLLPIEY 694
                                 .|:|        :.||.....|.       ::|:|...|:|:..
 Frog   698 ---------------------LEIA--------RKRHKGIGAFKSPHGTRPQACLKHIYLMPLSQ 733

  Fly   695 YHKHVPATALRQPLKGMTIVVSIYAGLERDFINATAELLGASVNKTFIKKEKPLLVCPSAEGSKY 759
            ..|.:.                         |..|.|...|..          |:|.|..|.:..
 Frog   734 IKKVLD-------------------------IKETEECHNAFA----------LVVRPPTEQTNQ 763

  Fly   760 EGAIKWNYPVVTS-----DWL-VQC---ARTGQKLPFVGYLVGKSPEDFPISPRLRDSNSRTARR 815
                .:::.:.|.     ||| :.|   |.|..|......:....|:...:|.:..||....|.|
 Frog   764 ----LFSFQLTTEELPKVDWLKMLCRHVANTICKADAENLIYSTDPDSLEVSTKDVDSTLSRASR 824

  Fly   816 PNEST---------LVAQPDVTMEEA---ENQPAGSVTPVTAG--SPGAPELTPLRNKRVSELAG 866
            ..:.|         ....|...::.|   :|....|..|.:.|  |...|..|.|...|.|....
 Frog   825 AIKKTSKKVTRAFSFTKTPKRALQRALMVQNADGRSPGPSSEGFASCRMPSTTSLAISRSSSTFS 889

  Fly   867 I--PGGSALHRGSNS------------TSSPDSPCT------------PLSQVGAQQYNLDFLEQ 905
            |  ||.....:.|||            ..||.||.|            |||         .|..:
 Frog   890 INGPGKHPSVQRSNSLDGSPRSRPVLCPGSPSSPLTHSLKGVANQSSPPLS---------PFSGK 945

  Fly   906 FVQRL------------DTEEGKD--CVREIIREMRE 928
            |.:.|            .:::|.|  ||::.:...||
 Frog   946 FCKTLVVPQTRTSGCAGQSQQGADPPCVKKSLSMKRE 982

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mus101	NP_524909.1	BRCT	127..189	CDD:349339	24/64 (38%)
		BRCT_TopBP1_rpt2_like	216..294	CDD:349363	14/79 (18%)
		BRCT_TopBP1_rpt3	392..476	CDD:349350	16/83 (19%)
		BRCT	707..786	CDD:469589	16/87 (18%)
		BRCT_TopBP1_rpt7	1208..1283	CDD:349370
		BRCT	1334..1414	CDD:469589
ect2	XP_012818117.1	BRCT_Ect2_rpt1	175..250	CDD:349365	27/78 (35%)
		BRCT_Ect2_rpt2	269..348	CDD:349364	14/92 (15%)
		RhoGEF	453..637	CDD:214619	35/229 (15%)
		PH_Ect2	628..800	CDD:269936	41/277 (15%)