DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ATP1B3 and GABA-B-R1

DIOPT Version :9

Sequence 1:	NP_001670.1	Gene:	ATP1B3 / 483	HGNCID:	806	Length:	279	Species:	Homo sapiens
Sequence 2:	NP_001246033.1	Gene:	GABA-B-R1 / 34878	FlyBaseID:	FBgn0260446	Length:	841	Species:	Drosophila melanogaster

Alignment Length:	161	Identity:	33/161 - (20%)
Similarity:	59/161 - (36%)	Gaps:	48/161 - (29%)

- Green bases have known domain annotations that are detailed below.

Human    31 RTAKSWGLILLFYLVFYGFLAALFSFTMWVMLQ-TLNDEVPKYRDQIPSPGLMVFPKPVTALEYT 94
            :..:.|.|        |..::.|.|..:.::|. .:.|.:.:|.:                   |
  Fly   574 KKVEPWKL--------YTMVSGLLSIDLVILLSWQIFDPLQRYLE-------------------T 611

Human    95 FSRSDPTSYAGYIEDLKKFLKPYT--LEEQKNLTVCPDGALFEQKGPVYVACQF------PISLL 151
            |...||.|..   :|:|  ::|..  .|.|:|....  |.::..||.:.|...|      .|.:.
  Fly   612 FPLEDPVSTT---DDIK--IRPELEHCESQRNSMWL--GLVYGFKGLILVFGLFLAYETRSIKVK 669

Human   152 QACSGMNDPDF-GYSQGNPCILVKMNRIIGL 181
            |    :||..: |.|..|..:|..:...:|:
  Fly   670 Q----INDSRYVGMSIYNVVVLCLITAPVGM 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP1B3	NP_001670.1	Na_K_ATPase_bet	1..279	CDD:273446	33/161 (20%)
ATP1B3	NP_001670.1	immunoglobulin-like. /evidence=ECO:0000250	186..279
GABA-B-R1	NP_001246033.1	PBP1_GABAb_receptor	34..437	CDD:107361
		ANF_receptor	52..415	CDD:279440
		7tm_3	476..730	CDD:278433	33/161 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3927
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900