Protein Alignment ATP1B3 and nrv2

DIOPT Version :10

• Sequence 1: NP_001670.1
• Gene: ATP1B3 / 483
• HGNCID: 806
• Length: 279
• Species: Homo sapiens
• Sequence 2: NP_477168.1
• Gene: nrv2 / 33953
• FlyBaseID: FBgn0015777
• Length: 323
• Species: Drosophila melanogaster
• Alignment Length: 319
• Identity: 89/319 - (27%)
• Similarity: 132/319 - (41%)
• Gaps: 70/319 - (21%)

Human     5 EKKSLNQSLAEWKLFIYNPTTGEFLGRTAKSWGLILLFYLVFYGFLAALFSFTMWVMLQTLNDEV 69
            :||||.|       .:|:.....:.||:..||..|.:||:.|||.||||.:..||...|||:..:
  Fly    24 KKKSLKQ-------MVYDSEDNSYFGRSMDSWAKIGIFYVAFYGVLAALVAICMWAFFQTLDPRI 81

Human    70 PKY---RDQI-PSPGLMVFP-KPVTALEYT---FSRSDPTSYAGYIEDLKKFLKPY-----TLEE 121
            ||:   |..| .:|||...| .||..:|.|   :..:...:|..:.:.|..||..|     |...
  Fly    82 PKWTLDRSLIGTNPGLGFRPLPPVDNVESTLIWYKGTQHENYKHWTDSLDDFLAVYKVPGLTPGR 146

Human   122 QKNLTVCPDGALFEQKGPVYVACQFPISLLQACSGMNDPDFGYSQGNPCILVKMNRIIGLKPEGV 186
            .:|:..|.    :.|..|....|...|.....|:..|  ::.|.:..|||.:|:|:|.|..||..
  Fly   147 GQNIYNCD----YNQPPPKGQVCDVDIKTWSPCTKEN--NYSYHKSAPCIFLKLNKIYGWIPEYY 205

Human   187 PR-------------------------------IDCVSKN----EDIPNVAVYPHNGMIDLKYFP 216
            .|                               :.|..:|    |:|..|...|..|.... ::|
  Fly   206 NRSNDLPANMPASLKTYIAEVEKTQPEKLNTIWVSCEGENPADQENIGAVNYLPIRGFPGY-FYP 269

Human   217 YYGKKLHVGYLQPLVAVQVSFAPNNTGKEVTVECKIDGSANLKSQDDRDKFLGRVMFKI 275
            |...:   |||.|||||.  |.....|..:.|||:. .:.|:  ..||.:.:|.|.:::
  Fly   270 YQNSE---GYLSPLVAVH--FQRPKRGIIINVECRA-WARNI--IHDRKERIGSVHYEL 320

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP1B3	NP_001670.1	Na_K_ATPase_bet	1..279	CDD:273446	89/319 (28%)
		immunoglobulin-like. /evidence=ECO:0000250	186..279		28/125 (22%)
nrv2	NP_477168.1	Na_K-ATPase	18..317	CDD:459748	88/314 (28%)