Protein Alignment ATP1B3 and nrv1

DIOPT Version :10

• Sequence 1: NP_001670.1
• Gene: ATP1B3 / 483
• HGNCID: 806
• Length: 279
• Species: Homo sapiens
• Sequence 2: NP_477167.1
• Gene: nrv1 / 33952
• FlyBaseID: FBgn0015776
• Length: 309
• Species: Drosophila melanogaster
• Alignment Length: 326
• Identity: 100/326 - (30%)
• Similarity: 145/326 - (44%)
• Gaps: 71/326 - (21%)

Human     1 MTKNEKK-----------SLNQSLAEWKLFIYNPTTGEFLGRTAKSWGLILLFYLVFYGFLAALF 54
            |:||..|           :..|:.:|   .||||..|.|.|||.|||..:||||.:||..|||||
  Fly     1 MSKNNGKGAKGEFEFPQPAKKQTFSE---MIYNPQEGTFFGRTGKSWSQLLLFYTIFYIVLAALF 62

Human    55 SFTMWVMLQTLNDEVPKYR--DQI--PSPGLMVFPKPVTALEYT-------FSRSDPTSYAGYIE 108
            :..|..:|.|::|..||::  |.:  .:|||..  :|::  |.|       |....|.....:||
  Fly    63 TICMQGLLSTISDTEPKWKLQDSLIGTNPGLGF--RPLS--EQTERGSVIAFDGKKPAESDYWIE 123

Human   109 DLKKFLKPYTLEEQKNLTVCPDGALFEQKGPVYVACQFPISLLQACSGMNDPDFGYSQGNPCILV 173
            .:..||:.|...|.:::..|..|.:.|   |..| |.....|...||..|  ::||....|||.:
  Fly   124 LIDDFLRDYNHTEGRDMKHCGFGQVLE---PTDV-CVVNTDLFGGCSKAN--NYGYKTNQPCIFL 182

Human   174 KMNRIIGLKPEGVPR-------------------------IDC---VSKN-EDIPNVAVYPHNGM 209
            |:|:|.|..||...:                         :.|   :.|: |:..|:..:|..|.
  Fly   183 KLNKIFGWIPEVYDKEEKDMPDDLKKVINETKTEERQQVWVSCNGHLGKDKENFQNIRYFPSQGF 247

Human   210 IDLKYFPYYGKKLHVGYLQPLVAVQVSFAPNNTGKEVTVECKIDGSANLKSQDDRDKFLGRVMFK 274
            ... |:|:..:.   |||.||||||.:..|.  |:.:.|||:........|...||: .|.|.|:
  Fly   248 PSY-YYPFLNQP---GYLSPLVAVQFNSPPK--GQMLDVECRAWAKNIQYSGSVRDR-KGSVTFQ 305

Human   275 I 275
            |
  Fly   306 I 306

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP1B3	NP_001670.1	Na_K_ATPase_bet	1..279	CDD:273446	100/326 (31%)
		immunoglobulin-like. /evidence=ECO:0000250	186..279		29/119 (24%)
nrv1	NP_477167.1	Na_K-ATPase	20..303	CDD:459748	93/302 (31%)