DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NMBR and CCHa1-R

DIOPT Version :9

Sequence 1:	NP_002502.2	Gene:	NMBR / 4829	HGNCID:	7843	Length:	390	Species:	Homo sapiens
Sequence 2:	NP_611241.2	Gene:	CCHa1-R / 37004	FlyBaseID:	FBgn0050106	Length:	499	Species:	Drosophila melanogaster

Alignment Length:	418	Identity:	141/418 - (33%)
Similarity:	220/418 - (52%)	Gaps:	56/418 - (13%)

- Green bases have known domain annotations that are detailed below.

Human    13 TGANESGSVPEGWERDFLPASDGTTTELVIRCVIPSLYLLIITVGLLGNIMLVKIFITNSAMRSV 77
            ||::|:.|.....|..::|.  |...|..|   :|.|:.||..||:|||..|:.:|::...||:|
  Fly    56 TGSSENFSELVTTETPYVPY--GRRPETYI---VPILFALIFVVGVLGNGTLIVVFLSVRQMRNV 115

Human    78 PNIFISNLAAGDLLLLLTCVPVDASRYFFDEWMFGKVGCKLIPVIQLTSVGVSVFTLTALSADRY 142
            ||.:|.:||..|||:::|.||:.::.|..:.|.:|...|.|...::..|:|||||||||||.|||
  Fly   116 PNTYILSLALADLLVIITTVPLASTVYTVEYWPYGSFLCSLSEFMKDVSIGVSVFTLTALSGDRY 180

Human   143 RAIVNPM-DMQTSG----ALLRTCVKAMGIWVVSVLLAVPEAVFSEVARISSLDNSSFTACIPYP 202
            .|||:|: .....|    |...|...|:.||::::|..:|..:.|.:..: .::..|...|.|||
  Fly   181 FAIVDPLRKFHAHGGGRRATRMTLATAVSIWLLAILCGLPALIGSNLKHL-GINEKSIVICYPYP 244

Human   203 QTDEL-HPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLIKSAHNLPGEYNEHTKKQMETRKRLAK 266
            :...: :.|...:|.||||:.|||.:|:::|..||..|:.|| ::|||. :...:|:..|:::|.
  Fly   245 EEWGINYAKSMVLLHFLVYYAIPLVVIAVFYVLIALHLMYSA-SVPGEI-QGAVRQVRARRKVAV 307

Human   267 IVLVFVGCFIFCWFPNHILYMYRSF------NYNEIDPSLGHMIVTLVARVLSFGNSCVNPFALY 325
            .||.||..|..|:.|.|:.:::..|      :||    :..| ::.:||..:||.|||.||.|||
  Fly   308 TVLAFVVIFGICFLPYHVFFLWFYFWPTAQDDYN----AFWH-VLRIVAYCMSFANSCANPVALY 367

Human   326 LLSESFRRHFNSQLCC----GR-----------------------KSYQERGTSYLLSSSAVRMT 363
            .:|.:||:|||..|.|    ||                       |.:|.|.:.|   .|.:|..
  Fly   368 FVSGAFRKHFNRYLFCRGASGRRKKRGQHDTFCMHRDTSLTSTASKRFQSRHSCY---QSTIRSC 429

Human   364 SLKSNAKNMVTNSVLLNGHSMKQ-EMAL 390
            .|:......:.|....||.::.. |:||
  Fly   430 RLQETTITTLPNGGNQNGANISAVELAL 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NMBR	NP_002502.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		4/8 (50%)
NMBR	NP_002502.2	7tm_1	60..322	CDD:278431	98/273 (36%)
CCHa1-R	NP_611241.2	7tm_4	88..>188	CDD:304433	47/99 (47%)
CCHa1-R	NP_611241.2	7tm_1	98..364	CDD:278431	98/273 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	177	1.000	Domainoid score	I3598
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20560
Inparanoid	1	1.050	217	1.000	Inparanoid score	I3601
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153238at2759
OrthoFinder	1	1.000	-	-		FOG0001846
OrthoInspector	1	1.000	-	-		mtm8658
orthoMCL	1	0.900	-	-		OOG6_106543
Panther	1	1.100	-	-	O	PTHR45695
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4897
SonicParanoid	1	1.000	-	-		X1046
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	12.000