DRSC/TRiP Functional Genomics Resources

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Protein Alignment NKX6-1 and HGTX

DIOPT Version :10

Sequence 1:NP_006159.2 Gene:NKX6-1 / 4825 HGNCID:7839 Length:367 Species:Homo sapiens
Sequence 2:NP_001368954.1 Gene:HGTX / 53446 FlyBaseID:FBgn0040318 Length:587 Species:Drosophila melanogaster


Alignment Length:371 Identity:150/371 - (40%)
Similarity:187/371 - (50%) Gaps:117/371 - (31%)


- Green bases have known domain annotations that are detailed below.


Human    14 AFLLSSPPLAALHSM-AEMKTPLYPAAYPPLPAGPPSSSSSSSSSSSPSPPLGTHNPGG--LKPP 75
            :||  .||||||||| .|||           ..|...||:|::..|.      :|:|..  :...
  Fly   291 SFL--GPPLAALHSMTTEMK-----------GQGVGGSSASANGLSY------SHSPNSHLISDR 336

Human    76 ATGGLSSLGSP----PQQLSAATPHGINDILSRPSMPVASGAALPSASPSGSSSSSSSSASASSA 136
            .:||.||..|.    .....|..||||:.|||:|. ||.|                         
  Fly   337 GSGGSSSSSSTTTTNTNSQGAPNPHGIDTILSKPP-PVTS------------------------- 375

Human   137 SAAAAAAAAAAAAASSPAGLLAGLPRFSSLSPPPPPPGLYFSPSAAAVAAVGRY-----PKPLAE 196
                       |..|:..|  ||:||||               .|||.|.:.:|     ..||..
  Fly   376 -----------AGLSALTG--AGIPRFS---------------IAAAAAGMAQYLSQSQGAPLKT 412

Human   197 LPG----RTPIFWP---GVMQSP-PWRDARLACT-------PHQGSILLDKDGKRKHTRPTFSGQ 246
            ..|    ||.::||   |::.:| .||: ||:.|       .||.....|||||:||||||||||
  Fly   413 HAGHIVDRTHLYWPGLQGLVANPIAWRE-RLSNTMSANLSQSHQHHPSNDKDGKKKHTRPTFSGQ 476

Human   247 QIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAEMATAKKKQDSETE 311
            |||||||||||||||||||||:|||:|||:|||||||||||||||||:|||||||||:|||.   
  Fly   477 QIFALEKTFEQTKYLAGPERAKLAYALGMSESQVKVWFQNRRTKWRKRHAAEMATAKRKQDD--- 538

Human   312 RLKGASENEEEDDDYNKPLDPNSDDEKITQ-----LLKKHKSSSGG 352
             :.|     :.|.|.::.:|  ||:|.:..     ..|:.:|:|.|
  Fly   539 -MGG-----DNDGDCSETMD--SDNESLDMGESPAQNKRCRSNSSG 576

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NKX6-1NP_006159.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 36..133 24/102 (24%)
Repressor domain. /evidence=ECO:0000250 102..268 71/185 (38%)
Homeodomain 235..293 CDD:459649 53/57 (93%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 294..367 23/64 (36%)
Involved in DNA-binding. /evidence=ECO:0000250 306..367 13/52 (25%)
HGTXNP_001368954.1 ROM1 179..>388 CDD:227709 43/154 (28%)
Homeodomain 465..523 CDD:459649 53/57 (93%)

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