Protein Alignment NKX6-1 and E5

DIOPT Version :10

• Sequence 1: NP_006159.2
• Gene: NKX6-1 / 4825
• HGNCID: 7839
• Length: 367
• Species: Homo sapiens
• Sequence 2: NP_524825.1
• Gene: E5 / 45396
• FlyBaseID: FBgn0008646
• Length: 524
• Species: Drosophila melanogaster
• Alignment Length: 453
• Identity: 112/453 - (24%)
• Similarity: 144/453 - (31%)
• Gaps: 161/453 - (35%)

Human    41 PPLPAGP--PSSSSSSSSSSSPSPPLGTHNPGGLKPPATGGLSSL-----------------GSP 86
            |..|..|  .||||.::||:|.|...........||.....:.|:                 ..|
  Fly    13 PMAPTSPFVSSSSSVAASSTSVSASSTVSASASSKPKLAFSIDSIVGESSTRSAPLRVSVISSPP 77

Human    87 PQQLSAATPHGINDILSRPSMPVASGAALP--------------SASPSGSSSSSSSSASASSAS 137
            |:..|.|:|...|:          ||...|              |.||..|..|.|.|...:..:
  Fly    78 PRSESPASPTNTNN----------SGRRTPRGYIYCRRRDSLDRSRSPQRSPVSRSPSPPNAGGN 132

Human   138 AAAAAAAAAAAAASS----PAGLLAGLP--------------------RFSSLSPPP--PPPGLY 176
            .|||...|.:...||    |..|:..||                    |.:....||  |||.|.
  Fly   133 PAAAGNTAKSGDPSSGTGNPPTLIRPLPLPAPNLALIGNRTSPNAMAVRMAGPPHPPSQPPPFLA 197

Human   177 FSPSAAAVAA------------------VGRYPKPLAEL-PGRTPI-FWPG---VMQSPPWRDAR 218
            .....||..|                  .|....|...| ||:.|: .:||   ....||.....
  Fly   198 AQFQMAAALAHHHQQQQQQQQQQLPPVPTGPPHGPHPHLPPGQIPLGIFPGGPHPGHPPPHGHHP 262

Human   219 LACTPH-----------------------QGSILLDKDGKRKHTRPTFSGQQIFALEKTFEQTKY 260
            ....||                       .|:.|.....|.|..|..||..|:..||..||...|
  Fly   263 FGSAPHLIRDSYPLYPWLLSRHGRIFPRFPGNFLFQPFRKPKRVRTAFSPTQLLKLEHAFEGNHY 327

Human   261 LAGPERARLAYSLGMTESQVKVWFQNRRTKWRK-------------------------------K 294
            :.|.||.:||..|.:||:||||||||||||.::                               |
  Fly   328 VVGAERKQLAQGLSLTETQVKVWFQNRRTKHKRMQQEGGDGSDTKSNKGSSSGGGGGGDGEDDAK 392

Human   295 HAAEMATAKKKQDSETERLKGASENEEED-------DDYNKPLDPNSDD---EKITQLLKKHK 347
            |.....:.:..:|.|.|     .|.||:|       |||...:|.....   |:..|.|.:|:
  Fly   393 HDGSQHSYEDAEDPEDE-----DEIEEDDEDEVIDMDDYGSEMDAEEHQRLREQFQQQLAQHQ 450

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NKX6-1	NP_006159.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..133		30/124 (24%)
		Repressor domain. /evidence=ECO:0000250	102..268		58/251 (23%)
		Homeodomain	235..293	CDD:459649	31/57 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	294..367		17/64 (27%)
		Involved in DNA-binding. /evidence=ECO:0000250	306..367		15/52 (29%)
E5	NP_524825.1	Homeodomain	304..360	CDD:459649	30/55 (55%)