DRSC/TRiP Functional Genomics Resources

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Protein Alignment NKX6-1 and Dr

DIOPT Version :10

Sequence 1:NP_006159.2 Gene:NKX6-1 / 4825 HGNCID:7839 Length:367 Species:Homo sapiens
Sequence 2:NP_477324.1 Gene:Dr / 45285 FlyBaseID:FBgn0000492 Length:515 Species:Drosophila melanogaster


Alignment Length:394 Identity:104/394 - (26%)
Similarity:152/394 - (38%) Gaps:117/394 - (29%)


- Green bases have known domain annotations that are detailed below.


Human    20 PPLAALH---------SMAEMKTPLYPAAYPPLPA--GPPSSSSS------SSSSSSPSP----- 62
            ||...||         |:|.:.....|.. ||..|  ||.:.:||      |.:||:|.|     
  Fly   119 PPAHHLHKTTSRLSNFSVASLLADTRPRT-PPNQAADGPQNLTSSAATSPISQASSTPPPPPASA 182

Human    63 ----PLGTHNPGGLKP-----PATGGLSSLGSPPQQLSAATPHGINDILSRPSMPVASGAALPSA 118
                |..|.:|..:..     .|....::..:..|.::|..........:|.:.|.||.::.||:
  Fly   183 AAQVPANTFHPAAVAHHAHLLQAAHAAAAAHAQHQAMAAQLRQQQQQADARANSPPASTSSTPSS 247

Human   119 SPSGSSSSSSSSASASSASAAAAAAAAAAA--------------------------------AAS 151
            :|.||:..|..:.:::.|.....:...:..                                |..
  Fly   248 TPLGSALGSQGNVASTPAKNERHSPLGSHTDSELEYDEEMLQDHEADHDEEEDSIVDIEDMNADD 312

Human   152 SPAGLLAGLPRF--SSLSPPPPPPGLY-----FSPSAAAVAAVGRYPKPLAELP----------G 199
            ||.....||...  |..||..||||.:     .||:|.|...|...|.|.:.|.          |
  Fly   313 SPRSTPDGLDGSGKSLESPHGPPPGSHMQSTILSPAALASGHVPIRPTPFSALAAAAVAWTGMGG 377

Human   200 RTPIFWPGVMQSPPW------------RDA----RLACTPHQGSILLDKDGKRKHTRPTFSGQQI 248
            ..|  |||..|.||:            .||    |:.|.       |.|....:..|..|:.||:
  Fly   378 GVP--WPGTRQMPPFGPPGMFPGAGFGGDANEPPRIKCN-------LRKHKPNRKPRTPFTTQQL 433

Human   249 FALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAEMATAKKKQDSETERL 313
            .:|||.|.:.:||:..|||..:.||.:||:|||:||||||.|           ||:.|::|.|::
  Fly   434 LSLEKKFREKQYLSIAERAEFSSSLRLTETQVKIWFQNRRAK-----------AKRLQEAEIEKI 487

Human   314 KGAS 317
            |.|:
  Fly   488 KMAA 491

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NKX6-1NP_006159.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 36..133 29/118 (25%)
Repressor domain. /evidence=ECO:0000250 102..268 57/230 (25%)
Homeodomain 235..293 CDD:459649 27/57 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 294..367 7/24 (29%)
Involved in DNA-binding. /evidence=ECO:0000250 306..367 5/12 (42%)
DrNP_477324.1 Homeodomain 422..478 CDD:459649 28/66 (42%)

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