DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NKX6-1 and slou

DIOPT Version :10

Sequence 1:NP_006159.2 Gene:NKX6-1 / 4825 HGNCID:7839 Length:367 Species:Homo sapiens
Sequence 2:NP_001262808.1 Gene:slou / 42547 FlyBaseID:FBgn0002941 Length:698 Species:Drosophila melanogaster


Alignment Length:392 Identity:108/392 - (27%)
Similarity:146/392 - (37%) Gaps:138/392 - (35%)


- Green bases have known domain annotations that are detailed below.


Human    21 PLAALHSMAEMKTPLYPAAYPPLPAGPPSS---SSSSSSSSSPSPPLGTHNPGGLKPPATGGLSS 82
            |.|..|    ::.|...:..||.||..|.|   |.:..|....|||:.        ||.....||
  Fly   234 PSAVFH----LRAPSSSSTAPPSPATSPLSPPTSPAMHSDQQMSPPIA--------PPQNPPHSS 286

Human    83 LGSPPQQLSAATPHGINDILSRPSMPVA---------SGAALPSASPSGSSSSSSSSASASSASA 138
              .||||...|.|..::  |.|..:..|         |.:||.|||.|.|::|.|.|.|:|.:.:
  Fly   287 --QPPQQQQVAAPSDMD--LERIKLVAAVAARTTQASSTSALASASNSVSNASISISNSSSGSPS 347

Human   139 ----------------AAAAAAAAA-----AAA-------------------------SSPAGLL 157
                            |||||||||     |||                         |:|:...
  Fly   348 GRDLSDYGFRIQLGGLAAAAAAAAATSRQIAAATYARSDTSEELNVDGNDEDSNDGSHSTPSVCP 412

Human   158 AGLPRFSSLSPPPPPPGLYFSPSAAAVAAVGRYPKPLAEL--PGRTPIFWPGVMQSPP------W 214
            ..|.|..:.|....|.....|.|:...||..|....:..:  |.:   |....:.|.|      |
  Fly   413 VDLTRSVNSSAAANPSSASTSASSDRDAATKRLAFSVENILDPNK---FTGNKLPSGPFGHPRQW 474

Human   215 ---RDARL------------------------ACTPHQGSILLDK--------------DGKR-- 236
               ||..:                        .|  ..||.:.|.              |||.  
  Fly   475 SYERDEEMQERLDDDQSEDMSAQDLNDMDQDDMC--DDGSDIDDPSSETDSKKGGSRNGDGKSGG 537

Human   237 --------KHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRK 293
                    :..|..|:.:|:.:||..|:.|:||:..||..||.||.:||:|||:|||||||||:|
  Fly   538 GGGGGSKPRRARTAFTYEQLVSLENKFKTTRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKK 602

Human   294 KH 295
            ::
  Fly   603 QN 604

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NKX6-1NP_006159.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 36..133 35/108 (32%)
Repressor domain. /evidence=ECO:0000250 102..268 64/279 (23%)
Homeodomain 235..293 CDD:459649 30/67 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 294..367 0/2 (0%)
Involved in DNA-binding. /evidence=ECO:0000250 306..367
slouNP_001262808.1 Homeodomain 546..602 CDD:459649 29/55 (53%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.