DRSC/TRiP Functional Genomics Resources

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Protein Alignment NKX6-1 and C15

DIOPT Version :10

Sequence 1:NP_006159.2 Gene:NKX6-1 / 4825 HGNCID:7839 Length:367 Species:Homo sapiens
Sequence 2:NP_476873.2 Gene:C15 / 42544 FlyBaseID:FBgn0004863 Length:339 Species:Drosophila melanogaster


Alignment Length:363 Identity:103/363 - (28%)
Similarity:135/363 - (37%) Gaps:114/363 - (31%)


- Green bases have known domain annotations that are detailed below.


Human    30 EMKTPLYPAAYPPLPAGPPSSSSSSSSSSSPSPPLGTHNPGGLKPPATGGLSSLGSPPQQLSAAT 94
            |.:|||..:.          .|..:.||||.:.|.              .:|.|.|.|.:.|...
  Fly    52 ESETPLSESL----------QSEQTRSSSSENLPF--------------SISRLLSKPFETSHHH 92

Human    95 PHGINDILSRPSMPVASGAALPSASPSGSSSSSSSSASASSASAAA-----AAAAAAAAAASSPA 154
            .:..|.:|              |:||..||::::|...........     .|...|.:.|:|..
  Fly    93 HNNNNHLL--------------SSSPGSSSNNNNSGEKGEEKELLQQEDHDLAYKLATSIANSTY 143

Human   155 GLLAGLPRFSSLSPPPPPPGLYFSPSAAAVAAVGRYPKPLAELPGRTPIFWPGVMQSPPWRDARL 219
            |..|.|..:         |.||  ||||. ..|.|.|      |.|||:.|    ..||...|.|
  Fly   144 GSAAALYSY---------PHLY--PSAAG-GHVLRVP------PQRTPLTW----ALPPLHHAAL 186

Human   220 ACTPHQGSILLDKD---------------------GKRKHTRPTFSGQQIFALEKTFEQTKYLAG 263
            |   ||..    ||                     .|||..|.:|:..|:..|||.|.:.||||.
  Fly   187 A---HQAV----KDRLAAAFPIARRIGHPYQNRTPPKRKKPRTSFTRIQVAELEKRFHKQKYLAS 244

Human   264 PERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAEMATAKKKQDSETERLKGASENEEEDDDYNK 328
            .|||.||..|.||::|||.||||||||||::.|.|    ::.:.....||..:.:.|.....:..
  Fly   245 AERAALARGLKMTDAQVKTWFQNRRTKWRRQTAEE----REAERQAANRLMLSLQAEAISKGFAP 305

Human   329 PLDPNSDDEKITQLLKKHKSSSGGGGG---LLLHASEP 363
            |..|              ..|.||..|   ..||..:|
  Fly   306 PSAP--------------LGSQGGVNGAPLAALHGLQP 329

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NKX6-1NP_006159.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 36..133 19/96 (20%)
Repressor domain. /evidence=ECO:0000250 102..268 54/191 (28%)
Homeodomain 235..293 CDD:459649 34/57 (60%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 294..367 14/73 (19%)
Involved in DNA-binding. /evidence=ECO:0000250 306..367 12/61 (20%)
C15NP_476873.2 COG5576 <196..315 CDD:227863 43/136 (32%)
Homeodomain 218..274 CDD:459649 32/55 (58%)

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