DRSC/TRiP Functional Genomics Resources

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Protein Alignment NKX6-1 and tin

DIOPT Version :10

Sequence 1:NP_006159.2 Gene:NKX6-1 / 4825 HGNCID:7839 Length:367 Species:Homo sapiens
Sequence 2:NP_524433.1 Gene:tin / 42536 FlyBaseID:FBgn0004110 Length:416 Species:Drosophila melanogaster


Alignment Length:373 Identity:89/373 - (23%)
Similarity:119/373 - (31%) Gaps:141/373 - (37%)


- Green bases have known domain annotations that are detailed below.


Human    26 HSMAEMKTPLYPAAYPPLPAGPPSSSSSSSSSSSPSPPLGTHNPGGLKPPATGGLSSLGSPPQ-- 88
            |..:|:..|.....:..|..|  :::|||.|...|.||...:          ||....|.|..  
  Fly    87 HQQSELPIPQQQLHHQHLDDG--ATTSSSLSPLLPPPPHQLY----------GGYQDYGMPAHMF 139

Human    89 QLSAATPHGINDILSRPSMPVASGAALPSASPSGSSSSSSSSASASSASAAAAAAAAAAAAASSP 153
            |.....||                            .|...||||.:.||:...|.|:|.|..:|
  Fly   140 QHHHGHPH----------------------------QSFQHSASAYNMSASQFYAGASATAYQTP 176

Human   154 AGL---LAGLPRFSSLSPPPPPPGLYFSPSAAAVAAVGRY-------PKPLAELPGRTPIFWPGV 208
            |..   .||...            :|...:.:||.....|       |.|..:|.....:   ..
  Fly   177 ATYNYNYAGSGE------------VYGGATPSAVGIKSEYIPTPYVTPSPTLDLNSSAEV---DS 226

Human   209 MQSPPWR------DARLACTPHQGSIL-----LDKDGKRK------------------------- 237
            :|:|..:      ..||..|....|.|     .|:..|:|                         
  Fly   227 LQAPTQKLCVNPLSQRLMETASNSSSLRSIYGSDEGAKKKDNSQVTSSRSELRKNSISGNSNPGS 291

Human   238 ---HTRP--------TFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKW 291
               .|:|        .||..|:..||..|...|||.|.||..:|..|.::.:|||:||||||.| 
  Fly   292 NSGSTKPRMKRKPRVLFSQAQVLELECRFRLKKYLTGAEREIIAQKLNLSATQVKIWFQNRRYK- 355

Human   292 RKKHAAEMATAKKKQDSETE----RLKGASENEEEDDDYNKPLD-PNS 334
                       .|:.|.:.|    .||..||          ||| |.|
  Fly   356 -----------SKRGDIDCEGIAKHLKLKSE----------PLDSPTS 382

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NKX6-1NP_006159.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 36..133 19/98 (19%)
Repressor domain. /evidence=ECO:0000250 102..268 46/222 (21%)
Homeodomain 235..293 CDD:459649 28/93 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 294..367 12/46 (26%)
Involved in DNA-binding. /evidence=ECO:0000250 306..367 11/34 (32%)
tinNP_524433.1 Homeodomain 302..358 CDD:459649 24/67 (36%)

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