Protein Alignment NKX6-1 and CG15696

DIOPT Version :10

• Sequence 1: NP_006159.2
• Gene: NKX6-1 / 4825
• HGNCID: 7839
• Length: 367
• Species: Homo sapiens
• Sequence 2: NP_650921.1
• Gene: CG15696 / 42469
• FlyBaseID: FBgn0038833
• Length: 179
• Species: Drosophila melanogaster
• Alignment Length: 226
• Identity: 55/226 - (24%)
• Similarity: 82/226 - (36%)
• Gaps: 89/226 - (39%)

Human   104 RPSMPVASGAALPSASPSGSSSSSSSSASASSASAAAAAAAAAAAAASSPAGLLAGLP-----RF 163
            |.|:|..     |.|.|  :|..|..|..:..||||.|.                 :|     ::
  Fly    31 RASLPFH-----PYAHP--ASYVSKESGGSPPASAAEAQ-----------------IPVYDWLQY 71

Human   164 SSLSPPPPPPGLYFSPSAAAVAAVGRYPKPLAELPGRTPIFWPGVMQSPPWRDARLACTPHQGSI 228
            :...||..|..|             |...|....|||.|               |:..||
  Fly    72 TRYHPPKLPRAL-------------RQNAPAKRTPGRLP---------------RIPFTP----- 103

Human   229 LLDKDGKRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRK 293
                             ||:.|||..::::.||:..:..:||.||.:|.::||:||||||.:.|:
  Fly   104 -----------------QQLQALENAYKESNYLSAEDANKLADSLELTNTRVKIWFQNRRARERR 151

Human   294 KHAAEMATAKKKQDSETERL--KGASENEEE 322
            :        |:::|...:..  ..||..|.|
  Fly   152 E--------KREKDESCDSTFSSNASSPEPE 174

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NKX6-1	NP_006159.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..133		9/28 (32%)
		Repressor domain. /evidence=ECO:0000250	102..268		35/168 (21%)
		Homeodomain	235..293	CDD:459649	20/57 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	294..367		6/31 (19%)
		Involved in DNA-binding. /evidence=ECO:0000250	306..367		5/19 (26%)
CG15696	NP_650921.1	Homeodomain	95..144	CDD:459649	21/85 (25%)