DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NKX6-1 and CG18599

DIOPT Version :10

Sequence 1:NP_006159.2 Gene:NKX6-1 / 4825 HGNCID:7839 Length:367 Species:Homo sapiens
Sequence 2:NP_650701.1 Gene:CG18599 / 42191 FlyBaseID:FBgn0038592 Length:475 Species:Drosophila melanogaster


Alignment Length:355 Identity:92/355 - (25%)
Similarity:141/355 - (39%) Gaps:95/355 - (26%)


- Green bases have known domain annotations that are detailed below.


Human    40 YPPLPAGPPSSSSSSSSSSSPSPPLGTHNP-GGLKPPATGGLSSLGSPPQQLSAATPHGINDILS 103
            :||.|....::::|||||:|.|     ||. ...:.......::..|..|.:.||..|...|:  
  Fly   110 HPPTPTTGNNNNNSSSSSNSSS-----HNSNSNHREQLAAAAATATSHAQLIEAAAAHSSLDV-- 167

Human   104 RPSMPVASGAALPS-----------------------------ASPSGSSSSSSSSASASSASAA 139
            ..|..:|:...|.|                             ::|:.:::::::..|.|..:  
  Fly   168 GKSFTIAAILGLQSQRKDYNNAINLSLHDNNNIIGDDNNKCYTSNPNNNNNNNNNGGSNSGNN-- 230

Human   140 AAAAAAAAAAASSPA------GLLAGLPRF---SSLSPPPPPPGLYFSPSAAAVAAVGRYPKPLA 195
                      .|||:      ..:||..|:   ....|.|...|.     ||..||||..|..|.
  Fly   231 ----------NSSPSVNNFNCDSVAGNGRYLHGGHQHPHPHQAGF-----AAVAAAVGAAPSALQ 280

Human   196 ELPGRTPIFWPGVMQSPPWRDARLACTPHQGSILLDKDGKRKHTRPTFSGQQIFALEKTFEQTKY 260
            .|.............:..::..:|....|:.|.|     |.|..|..|:.:|:..||..||:.:|
  Fly   281 SLQQLHQQHHAQQQATLSFQREKLKSDSHKKSAL-----KNKRVRTIFTPEQLECLEAEFERQQY 340

Human   261 LAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKH----AAEMATAKKKQ--------------- 306
            :.||||..||::|.:||:||||||||||.||||.|    ...:|..::.|               
  Fly   341 MVGPERLYLAHTLKLTEAQVKVWFQNRRIKWRKHHLELTQQRLALIRQTQLPGTSLLGNQVSVSA 405

Human   307 ----DSETERLKGAS----ENEEEDDDYNK 328
                ...|||..|.|    ..:|||::.:|
  Fly   406 NAAHSVSTERTNGCSAASPSLQEEDNEDSK 435

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NKX6-1NP_006159.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 36..133 23/122 (19%)
Repressor domain. /evidence=ECO:0000250 102..268 43/203 (21%)
Homeodomain 235..293 CDD:459649 31/57 (54%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 294..367 12/62 (19%)
Involved in DNA-binding. /evidence=ECO:0000250 306..367 10/46 (22%)
CG18599NP_650701.1 Homeodomain 317..373 CDD:459649 30/55 (55%)

Return to query results.
Submit another query.