DRSC/TRiP Functional Genomics Resources

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Protein Alignment NKX6-1 and Hmx

DIOPT Version :10

Sequence 1:NP_006159.2 Gene:NKX6-1 / 4825 HGNCID:7839 Length:367 Species:Homo sapiens
Sequence 2:NP_001262674.1 Gene:Hmx / 42110 FlyBaseID:FBgn0264005 Length:718 Species:Drosophila melanogaster


Alignment Length:531 Identity:123/531 - (23%)
Similarity:165/531 - (31%) Gaps:249/531 - (46%)


- Green bases have known domain annotations that are detailed below.


Human     4 VGAMEGTRQSAFLLSSPPLAALHSMAEMKTPLYPAAYPPLPAGPPSSSSSSSSSSSPSPPLGTHN 68
            :||  ..|.|..|..||..:| ...:...||.:.:..|...||.|::|:|..:....||      
  Fly    21 LGA--AARDSPLLARSPARSA-DGSSPPATPTHRSNTPNTAAGTPTTSASGGNHFHHSP------ 76

Human    69 PGGLKPPAT------GGLSSLGSPP-------------------------------------QQL 90
            .||..|||.      ..||||||.|                                     |||
  Fly    77 SGGAVPPAVLHHHLQHHLSSLGSHPVALHHALHTFGHLHPAHGATHPALLQHALTPTGQQQQQQL 141

Human    91 SAATPHGINDI--LSRP-SMPVASGAALPSASPSGSSSSSSSSASASSASAAAAAAAAAAAAA-- 150
            .....|..:.:  ||.| ..|..:|..........:::|.:.:.:.:.|||||||||||.|||  
  Fly   142 QVQQQHQQSHVERLSPPMKSPERNGGDEVQGHSLNNNNSKALNHNNTCASAAAAAAAAAVAAANL 206

Human   151 ------------------------------------SSP------AGLLAGLPRFSSLSPPPPPP 173
                                                |.|      |||:..:|:.     |.|..
  Fly   207 SNNSNDSNGSSGGGGGKSTTGSNGFTSFSISSILSRSEPAKKNGAAGLITPIPQL-----PQPGA 266

Human   174 GLYFSPSAAAV-----------AAVGRY---------------------------------PKPL 194
            |   .|..||:           |..|||                                 |.|.
  Fly   267 G---GPQDAAMLSRLGFISQWGALAGRYAALCPPGWPWAPQRLPFHSPTHDSSSTNTTENPPSPT 328

Human   195 AELPGRT-----------------------PIFWP-GVMQ------------------------- 210
            :..|...                       |::.| |..|                         
  Fly   329 SMSPNNNNNNSNTTASSNQASKSPSHHPLHPLYHPLGSQQQQQQQQQHQQHPQQQQHPQQQQQQH 393

Human   211 ----------SPPWRDARLACTPH------QGSILL-------DKDG------------------ 234
                      |.....:.|...||      .|..||       |::|                  
  Fly   394 PHQPTTPTSSSSSGGGSSLTHHPHPHLTGSHGGYLLPSSSNESDEEGEEIIEEDDGTDGPSDSSS 458

Human   235 --------KRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKW 291
                    ::|.||..||..|:|.||.||:..:||:..|||.||.||.:||:|||:||||||.||
  Fly   459 PHGDGNSKRKKKTRTVFSRAQVFQLESTFDLKRYLSSSERAGLAASLRLTETQVKIWFQNRRNKW 523

Human   292 RKKHAAEMATA 302
            :::.|||:..|
  Fly   524 KRQLAAELEAA 534

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NKX6-1NP_006159.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 36..133 30/142 (21%)
Repressor domain. /evidence=ECO:0000250 102..268 67/352 (19%)
Homeodomain 235..293 CDD:459649 33/57 (58%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 294..367 4/9 (44%)
Involved in DNA-binding. /evidence=ECO:0000250 306..367
HmxNP_001262674.1 Homeodomain 469..525 CDD:459649 33/55 (60%)
Blue background indicates that the domain is not in the aligned region.

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