Protein Alignment NKX6-1 and abd-A

DIOPT Version :10

• Sequence 1: NP_006159.2
• Gene: NKX6-1 / 4825
• HGNCID: 7839
• Length: 367
• Species: Homo sapiens
• Sequence 2: NP_732176.1
• Gene: abd-A / 42037
• FlyBaseID: FBgn0000014
• Length: 590
• Species: Drosophila melanogaster
• Alignment Length: 522
• Identity: 128/522 - (24%)
• Similarity: 190/522 - (36%)
• Gaps: 183/522 - (35%)

Human    13 SAFLLSSPPLAALHSMAEMKTPLYPAAYPPLPAGPPSSSSSSSSS-------------SSPSPPL 64
            |..|.::||.:   |.|.:...|..||.....:...||||:::||             ||.||..
  Fly    22 SHHLTTTPPNS---SSAAVAAALAAAAASASASVSASSSSNNNSSNTIAGSNTSNTNNSSSSPSS 83

Human    65 GTHNPGGLKPPATGGLSS-------LG-SPPQQLSAATP-------------------------- 95
            .::|...|.  .:||..|       || ||...:|:::|
  Fly    84 SSNNNSNLN--LSGGSLSPSHLSQHLGQSPHSPVSSSSPFQQHHPQVQQQHLNHQQQQHLHHQQQ 146

Human    96 -------------------HGIND----------------ILSRPS---MPVASGAALPSASPSG 122
                               |.|:.                :|:.||   ......:..||.|.||
  Fly   147 QHHHQYSSLSAALQLQQQQHHISKLAAAAVASHGHAHQQLLLTPPSAGNSQAGDSSCSPSPSASG 211

Human   123 SSS-----------SSSSSASASSASAAAAAAAAAAAAASS----------------PA--GLLA 158
            |||           |:|:|||||:||:.|||||||||||||                |:  |.|:
  Fly   212 SSSLHRSLNDNSPGSASASASASAASSVAAAAAAAAAAASSSFAIPTSKMYPYVSNHPSSHGGLS 276

Human   159 GLPRFSSLSPP------------------PPPPGLYFSP------------SAAAVAAVG----- 188
            |:..|:.|...                  |......|:.            |||:..|:|
  Fly   277 GMAGFTGLEDKSCSRYTDTVMNSYQSMSVPASASAQFAQFYQHATAAASAVSAASAGAIGVDSLG 341

Human   189 -RYPKPLA-ELPGRTPIFWPGVMQSP--PWRDARLACTPHQGS-----ILLDKDG----KRKHTR 240
             ...:|.: .:||.......|:...|  ||    :..|...||     :..|.:|    .|:..|
  Fly   342 NACTQPASGVMPGAGGAGGAGIADLPRYPW----MTLTDWMGSPFERVVCGDFNGPNGCPRRRGR 402

Human   241 PTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKK-HAAEMATAKK 304
            .|::..|...|||.|....||....|..:|::|.:||.|:|:||||||.|.:|: .|.:....:.
  Fly   403 QTYTRFQTLELEKEFHFNHYLTRRRRIEIAHALCLTERQIKIWFQNRRMKLKKELRAVKEINEQA 467

Human   305 KQDSE-------TERLKGASEN----EEEDDDYNKPLDPNSDDEKITQLLKKHKSSSGGGGGLLL 358
            ::|.|       .|.:|.|.:|    :::.....:........::..|..:.|.|......|.|.
  Fly   468 RRDREEQEKMKAQETMKSAQQNKQVQQQQQQQQQQQQQQQQQHQQQQQQPQDHHSIIAHNPGHLH 532

Human   359 HA 360
            |:
  Fly   533 HS 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NKX6-1	NP_006159.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..133		40/192 (21%)
		Repressor domain. /evidence=ECO:0000250	102..268		69/245 (28%)
		Homeodomain	235..293	CDD:459649	24/57 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	294..367		13/79 (16%)
		Involved in DNA-binding. /evidence=ECO:0000250	306..367		12/66 (18%)
abd-A	NP_732176.1	Homeodomain	399..455	CDD:459649	23/55 (42%)
		Abdominal-A	456..478	CDD:403567	3/21 (14%)