Protein Alignment NKX6-1 and Ubx

DIOPT Version :10

• Sequence 1: NP_006159.2
• Gene: NKX6-1 / 4825
• HGNCID: 7839
• Length: 367
• Species: Homo sapiens
• Sequence 2: NP_536752.1
• Gene: Ubx / 42034
• FlyBaseID: FBgn0003944
• Length: 389
• Species: Drosophila melanogaster
• Alignment Length: 281
• Identity: 71/281 - (25%)
• Similarity: 107/281 - (38%)
• Gaps: 74/281 - (26%)

Human    70 GGLKPPATGGLSSLGSPPQQLSAATPH----GINDILSRPSMPVASGAALPSASPSGSSSSS--- 127
            ||....|.|..:..|..|.:.||.||.    |..|......:....|:|..:.|.||.:.::
  Fly   135 GGNAANANGQNNPAGGMPVRPSACTPDSRVGGYLDTSGGSPVSHRGGSAGGNVSVSGGNGNAGGV 199

Human   128 ------SSSASASSASAAAAAAAAAAAAASS----------PAGLLAGLPRFSSLSPPPPPPGLY 176
                  :.:.:|.:|:...:.|||..|||||          |...:||       ..|..|....
  Fly   200 QSGVGVAGAGTAWNANCTISGAAAQTAAASSLHQASNHTFYPWMAIAG-------ECPEDPTKSK 257

Human   177 FSPSAAAVAAVG-----RYPKPLAELPGRTPIFWPGVMQSPPWRDARLACTPHQGSIL---LDKD 233
            ..........:.     ||.:.||                              ||:|   |..:
  Fly   258 IRSDLTQYGGISTDMGKRYSESLA------------------------------GSLLPDWLGTN 292

Human   234 GKRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAE 298
            |.|:..|.|::..|...|||.|....||....|..:|::|.:||.|:|:||||||.|.:|    |
  Fly   293 GLRRRGRQTYTRYQTLELEKEFHTNHYLTRRRRIEMAHALCLTERQIKIWFQNRRMKLKK----E 353

Human   299 MATAKK--KQDSETERLKGAS 317
            :...|:  :|:.:.:..|.|:
  Fly   354 IQAIKELNEQEKQAQAQKAAA 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NKX6-1	NP_006159.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..133		17/75 (23%)
		Repressor domain. /evidence=ECO:0000250	102..268		40/192 (21%)
		Homeodomain	235..293	CDD:459649	24/57 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	294..367		5/26 (19%)
		Involved in DNA-binding. /evidence=ECO:0000250	306..367		3/12 (25%)
Ubx	NP_536752.1	Homeodomain	296..352	CDD:459649	23/55 (42%)