DRSC/TRiP Functional Genomics Resources

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Protein Alignment NKX6-1 and Dfd

DIOPT Version :10

Sequence 1:NP_006159.2 Gene:NKX6-1 / 4825 HGNCID:7839 Length:367 Species:Homo sapiens
Sequence 2:NP_477201.1 Gene:Dfd / 40832 FlyBaseID:FBgn0000439 Length:586 Species:Drosophila melanogaster


Alignment Length:381 Identity:76/381 - (19%)
Similarity:129/381 - (33%) Gaps:135/381 - (35%)


- Green bases have known domain annotations that are detailed below.


Human    49 SSSSSSSSSSSPSPPLGTHNPGGLKPPATGGLSSLG----SPPQQLSAATPHGINDILSRPSMPV 109
            |:...||:.::.:||...|:.....|.     .|||    ..|:.:||...|      |.|:...
  Fly   123 SAGGYSSNYANATPPSHPHSHPHAHPH-----QSLGYYVHHAPEFISAGAVH------SDPTNGY 176

Human   110 ASGAALPSASPSGSSSSSSS----SASASSAS-----------AAAAAAAAAAAAASSPAGLLAG 159
            ...|.:|:.|..|....|.:    .|...||:           .|..:..:..:...||...:..
  Fly   177 GPAANVPNTSNGGGGGGSGAVLGGGAVGGSANGYYGGYGGGYGTANGSVGSTHSQGHSPHSQMMD 241

Human   160 LPRFSSLSPPPPPPGLYFSPSAAAVAAVG-RYPKPLAE-LPGRTPIFWPGVMQSPPWRDARLAC- 221
            ||...|.:.||       :.:|..:..:| :..|.:.| :|....:...|:         ||.| 
  Fly   242 LPLQCSSTEPP-------TNTALGLQELGLKLEKRIEEAVPAGQQLQELGM---------RLRCD 290

Human   222 --------TPHQGSILLDK----------------------------DGKR-------------- 236
                    ...:..::||:                            ||:|              
  Fly   291 DMGSENDDMSEEDRLMLDRSPDELGSNDNDDDLGDSDSDEDLMAETTDGERIIYPWMKKIHVAGV 355

Human   237 -----------KHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTK 290
                       |..|..::..||..|||.|...:||....|..:|::|.::|.|:|:||||||.|
  Fly   356 ANGSYQPGMEPKRQRTAYTRHQILELEKEFHYNRYLTRRRRIEIAHTLVLSERQIKIWFQNRRMK 420

Human   291 WRK-------------------------KHAAEMATAKKKQDSETERLKGASENEE 321
            |:|                         |...:.|.:||:|.::.::.....:.::
  Fly   421 WKKDNKLPNTKNVRKKTVDANGNPTPVAKKPTKRAASKKQQQAQQQQQSQQQQTQQ 476

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NKX6-1NP_006159.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 36..133 22/91 (24%)
Repressor domain. /evidence=ECO:0000250 102..268 43/244 (18%)
Homeodomain 235..293 CDD:459649 25/82 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 294..367 5/28 (18%)
Involved in DNA-binding. /evidence=ECO:0000250 306..367 1/16 (6%)
DfdNP_477201.1 Homeodomain 367..423 CDD:459649 24/55 (44%)

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