Protein Alignment NKX6-1 and pb

DIOPT Version :10

• Sequence 1: NP_006159.2
• Gene: NKX6-1 / 4825
• HGNCID: 7839
• Length: 367
• Species: Homo sapiens
• Sequence 2: NP_476669.3
• Gene: pb / 40826
• FlyBaseID: FBgn0051481
• Length: 782
• Species: Drosophila melanogaster
• Alignment Length: 322
• Identity: 87/322 - (27%)
• Similarity: 128/322 - (39%)
• Gaps: 73/322 - (22%)

Human    49 SSSSSSSSSSSPSPPL-----GTHNPGGLKPPATGGLSSLGSPPQQLSAATPHGINDILSRPSMP 108
            :|..:...|.||..||     .|..|.|    ..||...:|.         ..|:...:.:|.:.
  Fly    11 TSMGTQIKSESPLNPLQVQTGQTSLPVG----GCGGAGVVGG---------VGGVGVSVGQPGIG 62

Human   109 VASGAALPSASPSGSSSSSSSSASASSASAAAAAAAAAAAAASSPAGLLAGLPRFSSLSPPPPPP 173
            ......:||.......:.:....||.:|....|:......:..|.|..|      :.|||..|..
  Fly    63 QQGVPPVPSVLMVNKMTPNCDKRSADTAYWMTASEGGFINSQPSMAEFL------NHLSPESPKI 121

Human   174 GLYFSP-SAAAVAAVG-----------RYPKPLAELPGRTPIFWPGVMQSP--PW-----RDARL 219
            |   :| .:.|:..||           .|  |:..:| :||   .|:...|  ||     ...:.
  Fly   122 G---TPVGSGAIGGVGVNVNVNVGVGVGY--PVGVVP-QTP---DGMDSVPEYPWMKEKKTSRKS 177

Human   220 ACTPHQG--SI--LLDKDGKRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQV 280
            :...:||  ||  .:.::|..:..|..::..|:..|||.|...|||..|.|..:|.||.:||.||
  Fly   178 SNNNNQGDNSITEFVPENGLPRRLRTAYTNTQLLELEKEFHFNKYLCRPRRIEIAASLDLTERQV 242

Human   281 KVWFQNRRTKWRKKHAAEMATAKKKQDSET-ERLKGASENEEEDDDYNKPLDPNSDDEKITQ 341
            ||||||||.|.:::      |..|..|.:. :.|||       |||.:   |.||:.:|..|
  Fly   243 KVWFQNRRMKHKRQ------TLSKTDDEDNKDSLKG-------DDDQS---DSNSNSKKSCQ 288

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NKX6-1	NP_006159.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..133		16/88 (18%)
		Repressor domain. /evidence=ECO:0000250	102..268		44/188 (23%)
		Homeodomain	235..293	CDD:459649	27/57 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	294..367		14/49 (29%)
		Involved in DNA-binding. /evidence=ECO:0000250	306..367		12/37 (32%)
pb	NP_476669.3	Homeodomain	199..255	CDD:459649	27/55 (49%)