DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NKX6-1 and lab

DIOPT Version :10

Sequence 1:NP_006159.2 Gene:NKX6-1 / 4825 HGNCID:7839 Length:367 Species:Homo sapiens
Sequence 2:NP_476613.1 Gene:lab / 40817 FlyBaseID:FBgn0002522 Length:629 Species:Drosophila melanogaster


Alignment Length:417 Identity:85/417 - (20%)
Similarity:137/417 - (32%) Gaps:127/417 - (30%)


- Green bases have known domain annotations that are detailed below.


Human     3 AVGAMEGTRQSAFLLSSPPLAALHSMAE---------MKTPLYPAAYP--PLPAGPPSSSSSSSS 56
            |:.||:.....|.:....|...|.::|.         .:....|...|  |....|.:......:
  Fly   276 ALDAMDSLGMHAHMHHGLPHGHLGNLANNPHQQQPQVQQQQQQPHQQPQHPQNQSPAAHQQHHQN 340

Human    57 SSSPSPPLGTHNPGGLKPPATGGLSSL----GSPPQQLSAATPHGINDI-------LSR------ 104
            |.||:..:.....||:..|.:...||.    |:.|....:.:|:..:.|       |.|      
  Fly   341 SVSPNGGMNRQQRGGVISPGSSTSSSTSASNGAHPASTQSKSPNHSSSIPTYKWMQLKRNVPKPQ 405

Human   105 -PSMPVASGAALPSASPS-----------------------GSSSSSSSSASASSASAAAAAAAA 145
             |.:|.:..|::.....:                       |.:.|.......|..::...|.:|
  Fly   406 APKLPASGIASMHDYQMNGQLDMCRGGGGGGSGVGNGPVGVGGNGSPGIGGVLSVQNSLIMANSA 470

Human   146 AAAAASSPAGLLAGLPRFSSLSPPPPPPGLYFSPSAAAVAAVGRYPKPLAELPGRTPIFWPGVMQ 210
            |||.::.|.|:..||...|.||                                           
  Fly   471 AAAGSAHPNGMGVGLGSGSGLS------------------------------------------- 492

Human   211 SPPWRDARLACTPHQGSILLDKDGKRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGM 275
                     :|:....:   :..|     |..|:.:|:..|||.|...:||....|..:|.:|.:
  Fly   493 ---------SCSLSSNT---NNSG-----RTNFTNKQLTELEKEFHFNRYLTRARRIEIANTLQL 540

Human   276 TESQVKVWFQNRRTKWRKKHAAEMATAKKKQDSETERLKGASENEEEDDDYNKPLDPNSDDEKIT 340
            .|:|||:||||||.|.:|:....:..|    |..|:.  ..|...|:.....:|..|        
  Fly   541 NETQVKIWFQNRRMKQKKRVKEGLIPA----DILTQH--STSVISEKPPQQQQPQPP-------- 591

Human   341 QLLKKHKSSSGGGGGLLLHA-SEPESS 366
            :|..|.:.|..||..|...| |.|.::
  Fly   592 ELQLKSQGSDLGGNELATGAPSTPTTA 618

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NKX6-1NP_006159.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 36..133 23/139 (17%)
Repressor domain. /evidence=ECO:0000250 102..268 32/195 (16%)
Homeodomain 235..293 CDD:459649 23/57 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 294..367 16/74 (22%)
Involved in DNA-binding. /evidence=ECO:0000250 306..367 15/62 (24%)
labNP_476613.1 Homeodomain 505..558 CDD:459649 23/52 (44%)

Return to query results.
Submit another query.