Protein Alignment NKX6-1 and Dll

DIOPT Version :10

• Sequence 1: NP_006159.2
• Gene: NKX6-1 / 4825
• HGNCID: 7839
• Length: 367
• Species: Homo sapiens
• Sequence 2: NP_001137759.1
• Gene: Dll / 37973
• FlyBaseID: FBgn0000157
• Length: 347
• Species: Drosophila melanogaster
• Alignment Length: 272
• Identity: 71/272 - (26%)
• Similarity: 110/272 - (40%)
• Gaps: 43/272 - (15%)

Human   100 DILSRPSMP--VASGAALPSASPSGSSSSSSSSASASSASAAAAAAAAAAAAASSP-AGLLAGLP 161
            |....|..|  :..|....|.:|..:....|:.......:||......:......| .|..:|.|
  Fly     2 DAPDAPHTPKYMDGGNTAASVTPGINIPGKSAFVELQQHAAAGYGGIRSTYQHFGPQGGQDSGFP 66

Human   162 R-FSSLSPPPPPPGLYFSPSAAAVAAVGRYPKPLAELPGRTPIFWPGVMQSPPWRDARLACTPHQ 225
            . .|:|..|.||    ...::.:...:|.|..|.|               |||..|..::.....
  Fly    67 SPRSALGYPFPP----MHQNSYSGYHLGSYAPPCA---------------SPPKDDFSISDKCED 112

Human   226 GSILLDKDGKR-KHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRT 289
            ..:.::..||: :..|..:|..|:..|.:.|::|:|||.||||.||.|||:|::|||:||||||:
  Fly   113 SGLRVNGKGKKMRKPRTIYSSLQLQQLNRRFQRTQYLALPERAELAASLGLTQTQVKIWFQNRRS 177

Human   290 KWRKKHAAEMATAKKKQDSETERLKGASENEEEDDDYNKPLDPNSDD-----------EKITQLL 343
            |::|.    |..|:....:....|.|...|..:    :.|...:|.:           |....|.
  Fly   178 KYKKM----MKAAQGPGTNSGMPLGGGGPNPGQ----HSPNQMHSGELANGRFLWAALETNGTLA 234

Human   344 KKHKSSSGGGGG 355
            ..|.:....|||
  Fly   235 LVHSTGGNNGGG 246

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NKX6-1	NP_006159.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..133		7/34 (21%)
		Repressor domain. /evidence=ECO:0000250	102..268		39/170 (23%)
		Homeodomain	235..293	CDD:459649	30/58 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	294..367		13/73 (18%)
		Involved in DNA-binding. /evidence=ECO:0000250	306..367		11/61 (18%)
Dll	NP_001137759.1	Homeodomain	125..181	CDD:459649	29/55 (53%)