DRSC/TRiP Functional Genomics Resources

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Protein Alignment NKX6-1 and unpg

DIOPT Version :10

Sequence 1:NP_006159.2 Gene:NKX6-1 / 4825 HGNCID:7839 Length:367 Species:Homo sapiens
Sequence 2:NP_477146.1 Gene:unpg / 35942 FlyBaseID:FBgn0015561 Length:485 Species:Drosophila melanogaster


Alignment Length:422 Identity:88/422 - (20%)
Similarity:129/422 - (30%) Gaps:185/422 - (43%)


- Green bases have known domain annotations that are detailed below.


Human    17 LSSPPLAALHSMAEMKTPLYPAAYPPLPAGPPSSSSSSSSSSSP---SPPLGTHNPGGLKPPATG 78
            :..|.|.....:..|::|....|..|.|  .|.|..|..::.:|   :||         .||...
  Fly     1 MERPALLQNGEIGTMESPTTRLASKPFP--KPFSIESLIANQTPATATPP---------SPPEER 54

Human    79 GLSSLGSPPQQLS-----AATPHGINDI-LSRPSMP-------------VASGAALPSASPSGSS 124
            .........|:||     |::..|:... |..|.:.             :|.|..||| ||:|..
  Fly    55 DQEQEAEQEQELSARAMVASSALGLTQFPLYNPWLHGYFAQNHERLTHLIAGGCYLPS-SPAGHP 118

Human   125 SSSSSSASASSASAAAAAAAAAAAAASSPAGLLAGLPRFSSLSPPPPPPG--------------- 174
            ::....|.|..                               .||||.|.               
  Fly   119 AAQQPQAQAQP-------------------------------QPPPPHPPTHALEKQLPPTLPHP 152

Human   175 -----LYFSPSAAAVAAVGRYPKPLAELPGRTPIFW----------------------PGVMQ-- 210
                 |.|:|:||.||......:.||||..:..:..                      ||:.|  
  Fly   153 LDTRFLPFNPAAAGVAPTDLSYRRLAELMNQDYVHSLSVHARLQHMAAAGRMHEDQANPGMAQLQ 217

Human   211 --SPP---------------------------------WRDARLACTP----------------- 223
              :||                                 ..|..|..:|                 
  Fly   218 EPTPPQAHSSPAKSGSHSPMEPALDVGMDEDFECSGDSCSDISLTMSPRNYNGEMDKSRNGAYTN 282

Human   224 ---------------HQGSILLDKD---------GKRKHTRPTFSGQQIFALEKTFEQTKYLAGP 264
                           |:|..:..||         .|.:..|..|:.:|:..||:.|...|||:..
  Fly   283 SDSEDCSDDEGAQSRHEGGGMGGKDSQGNGSSSNSKSRRRRTAFTSEQLLELEREFHAKKYLSLT 347

Human   265 ERARLAYSLGMTESQVKVWFQNRRTKWRKKHA 296
            ||:::|.||.::|.|||:||||||.||::..|
  Fly   348 ERSQIATSLKLSEVQVKIWFQNRRAKWKRVKA 379

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NKX6-1NP_006159.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 36..133 27/118 (23%)
Repressor domain. /evidence=ECO:0000250 102..268 52/298 (17%)
Homeodomain 235..293 CDD:459649 27/57 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 294..367 1/3 (33%)
Involved in DNA-binding. /evidence=ECO:0000250 306..367
unpgNP_477146.1 Homeodomain 324..376 CDD:459649 25/51 (49%)
Blue background indicates that the domain is not in the aligned region.

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