DRSC/TRiP Functional Genomics Resources

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Protein Alignment NKX6-1 and H2.0

DIOPT Version :10

Sequence 1:NP_006159.2 Gene:NKX6-1 / 4825 HGNCID:7839 Length:367 Species:Homo sapiens
Sequence 2:NP_523488.2 Gene:H2.0 / 33841 FlyBaseID:FBgn0001170 Length:418 Species:Drosophila melanogaster


Alignment Length:407 Identity:98/407 - (24%)
Similarity:132/407 - (32%) Gaps:140/407 - (34%)


- Green bases have known domain annotations that are detailed below.


Human    52 SSSSSSSSPSPPLGTHNPGGLKPPATGGLSSLGSPPQQLSAATPHGINDILSRPSMPVASGAALP 116
            |::|...|....|.||..|..:...|             .|..|..:|.....|:....:...:.
  Fly     6 SAASMEQSMPENLSTHMYGECEVNPT-------------LAKCPDPVNVDHELPTKESCASTTIV 57

Human   117 SASPS------------------GSSSSSSSSASASSASAAAAAAAAAAAAASSP---AGLLAGL 160
            |.||:                  ||....|...|:||.|..:....:..|..|.|   :...|..
  Fly    58 STSPTSATSTTKVKLSFSVDRLLGSEPEESHRQSSSSPSTKSCCDGSILACCSFPHCFSQANAES 122

Human   161 PRFSSLSPPPP---------P--------PGLYF--------SPSAAAVAAVGRYP--------- 191
            .||...:.||.         |        ||.|.        :|..||..|...||         
  Fly   123 RRFGHATLPPTFTPTSSHTYPFVGLDKLFPGPYMDYKSVLRPTPIRAAEHAAPTYPTLATNALLR 187

Human   192 --------------------------KP-----------LAELP---------------GRTPIF 204
                                      ||           ||.|.               |:||..
  Fly   188 FHQHQKQQHQQHHHHQHHPKHLHQQHKPPPHNSTTASALLAPLHSLTSLQLTQQQQRFLGKTPQQ 252

Human   205 WPGVMQSPPWRDARLACTPH-----------QGSILLDKDGKRKH--TRPTFSGQQIFALEKTFE 256
            ...:..:.|  .|..|.|..           ||:.....:||||.  :|..||..|...||..|:
  Fly   253 LLDIAPTSP--AAAAAATSQNGAHGHGGGNGQGNASAGSNGKRKRSWSRAVFSNLQRKGLEIQFQ 315

Human   257 QTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAE-MATAKKKQDSETERLKGA--SE 318
            |.||:..|:|.:||..|.:|::||||||||||.|||  |..| :.:.::||.|......|.  :.
  Fly   316 QQKYITKPDRRKLAARLNLTDAQVKVWFQNRRMKWR--HTRENLKSGQEKQPSAVPESGGVFKTS 378

Human   319 NEEEDDDYNKPLDPNSD 335
            ....|....:.||.:||
  Fly   379 TPSGDGTPQEALDYSSD 395

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NKX6-1NP_006159.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 36..133 18/98 (18%)
Repressor domain. /evidence=ECO:0000250 102..268 59/285 (21%)
Homeodomain 235..293 CDD:459649 31/59 (53%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 294..367 11/45 (24%)
Involved in DNA-binding. /evidence=ECO:0000250 306..367 8/32 (25%)
H2.0NP_523488.2 Homeodomain 292..352 CDD:459649 32/61 (52%)

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