Protein Alignment NKX6-1 and scro

DIOPT Version :10

• Sequence 1: NP_006159.2
• Gene: NKX6-1 / 4825
• HGNCID: 7839
• Length: 367
• Species: Homo sapiens
• Sequence 2: NP_001015473.1
• Gene: scro / 3355151
• FlyBaseID: FBgn0287186
• Length: 468
• Species: Drosophila melanogaster
• Alignment Length: 267
• Identity: 65/267 - (24%)
• Similarity: 106/267 - (39%)
• Gaps: 75/267 - (28%)

Human    43 LPAGPPSSSSSSSSSSSPSPPLGTHNPGGLKPPATGGLSSLGSPPQQLSAATPHGINDILSRPSM 107
            |...|||...|:|||||      .::||.|...               :.|.|:.:..:...|.:
  Fly   134 LNGNPPSPFRSNSSSSS------INSPGTLTTS---------------TMANPYAMGTLYHSPGV 177

Human   108 PVASGAALPSASPSGSSSSSSSSASASSASAAAAAAAAAAAAASSPAGLLAGLPRFSSLSPPPPP 172
            ....|.. .:.|.:|..:...:|||...::|.....|.:...:||.:|.::.:...|.|
  Fly   178 QTYCGPT-DNLSLAGHYTDMRNSASWYGSTANDPRFAISRLMSSSASGTMSHMGNMSGL------ 235

Human   173 PGLYFSPSAAAVAAVGRYPKPLAELPGRTPIFWPGVMQSPPWRDARLACTPHQGSILLDKDGKRK 237
                   :|.:|:.......|||:                                       |:
  Fly   236 -------AACSVSDSKPLQFPLAQ---------------------------------------RR 254

Human   238 HTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAEMATA 302
            ..|..|:..|::.||:.|:|.:||:.|||..||..:.:|.:|||:||||.|.|. |:.|.|.|.|
  Fly   255 KRRVLFTQAQVYELERRFKQQRYLSAPEREHLASLIHLTPTQVKIWFQNHRYKC-KRQAKEKAMA 318

Human   303 KKKQDSE 309
            ::.|.::
  Fly   319 EQNQHNQ 325

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NKX6-1	NP_006159.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..133		21/89 (24%)
		Repressor domain. /evidence=ECO:0000250	102..268		32/165 (19%)
		Homeodomain	235..293	CDD:459649	25/57 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	294..367		5/16 (31%)
		Involved in DNA-binding. /evidence=ECO:0000250	306..367		1/4 (25%)
scro	NP_001015473.1	Homeodomain	254..310	CDD:459649	24/56 (43%)