Protein Alignment NKX6-1 and B-H1

DIOPT Version :10

• Sequence 1: NP_006159.2
• Gene: NKX6-1 / 4825
• HGNCID: 7839
• Length: 367
• Species: Homo sapiens
• Sequence 2: NP_523387.1
• Gene: B-H1 / 32724
• FlyBaseID: FBgn0011758
• Length: 544
• Species: Drosophila melanogaster
• Alignment Length: 297
• Identity: 86/297 - (28%)
• Similarity: 126/297 - (42%)
• Gaps: 50/297 - (16%)

Human    49 SSSSSSSSSSSPSPPLGTHNPGGLKPPAT-----GGLSSLGSPPQQLSAATPHGINDILSRPS-- 106
            :::|.||..|||:.....:|..|....|:     |.|.|....||......||.....|..|.
  Fly   107 NNNSGSSGGSSPAHSNNNNNINGDNCEASNVAGVGVLPSALHHPQPHPPTHPHTHPHALMHPHGK 171

Human   107 ----MPVASGAALPSASPSGSSSSSSSSASASSASAAAAAAAAAAAAASSPAGLLAGLPRFSSLS 167
                .|.|.|..|..|..:.:.....::|:|::|:...||||||||||::.||:.|
  Fly   172 LGHFPPTAGGNGLNVAQYAAAMQQHYAAAAAAAAARNNAAAAAAAAAAAAAAGVAA--------- 227

Human   168 PPPPPPGLYFSPSAAAVAAVGRYPKPLAELPGRTPIFWPGVMQSPPWRDARLACTPHQGSILLDK 232
              ||..|       .....||..|....:|...:..............|....|: :.|.   |.
  Fly   228 --PPVDG-------GVDGGVGLAPPAGGDLDDSSDYHEENEDCDSGNMDDHSVCS-NGGK---DD 279

Human   233 DG----------------KRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVK 281
            ||                |::..|..|:..|:..|||:||:.|||:..||..||:.|.:::.|||
  Fly   280 DGNSVKSGSTSDMSGLSKKQRKARTAFTDHQLQTLEKSFERQKYLSVQERQELAHKLDLSDCQVK 344

Human   282 VWFQNRRTKWRKKHAAEM-ATAKKKQDSETERLKGAS 317
            .|:|||||||:::.|..: ..|:....:..:||.|.|
  Fly   345 TWYQNRRTKWKRQTAVGLELLAEAGNFAAFQRLYGGS 381

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NKX6-1	NP_006159.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..133		24/94 (26%)
		Repressor domain. /evidence=ECO:0000250	102..268		50/187 (27%)
		Homeodomain	235..293	CDD:459649	28/57 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	294..367		6/25 (24%)
		Involved in DNA-binding. /evidence=ECO:0000250	306..367		4/12 (33%)
B-H1	NP_523387.1	Homeodomain	300..356	CDD:459649	27/55 (49%)