Protein Alignment NKX6-1 and B-H2

DIOPT Version :10

• Sequence 1: NP_006159.2
• Gene: NKX6-1 / 4825
• HGNCID: 7839
• Length: 367
• Species: Homo sapiens
• Sequence 2: NP_523386.1
• Gene: B-H2 / 32723
• FlyBaseID: FBgn0004854
• Length: 645
• Species: Drosophila melanogaster
• Alignment Length: 493
• Identity: 98/493 - (19%)
• Similarity: 145/493 - (29%)
• Gaps: 257/493 - (52%)

Human    47 PPSSSSSSSSSSSPSPPLGTHNPGGLKPPATGGLSSLGSPPQQLSAATPHGINDILSRPSMPVAS 111
            ||..|:::::....:|....|:|.     |.||    |.|                 ||:.| |.
  Fly     5 PPEMSATTAAPVGSAPSATAHHPA-----AVGG----GMP-----------------RPASP-AV 42

Human   112 GAALPSASPSGSSSS----SSSSASASSASAAAAAAAAAAAAASSPAGLLAGLP----RFSSL-- 166
            |:...:|:.:.::.|    :...|.|::|||||||||||.|||||..|  .|.|    |..||
  Fly    43 GSNTTTATATTATRSRFMITDILAGAAAASAAAAAAAAALAAASSGGG--RGSPTDSEREQSLVA 105

Human   167 -----------------------------------------------------------SPP--- 169
                                                                       |||
  Fly   106 QHHHHHQQQQQHHHHQQQQQQQQHQQAALQQYIVQQQQLLRFEREREREREREHYRERHSPPGNN 170

Human   170 -----PPPPGL--YFSPSAAAVAAVGRYPKPLAELP------------------GRTPIFWPGVM 209
                 |.||.|  :|.|:..||....:..:...:.|                  |.      |:.
  Fly   171 PYAHHPMPPHLLAHFPPAHYAVLQQQQQQQQQQQHPHPHHLQLERERLEALHRHGH------GLT 229

Human   210 QSPPWRDARLACTPHQ------------------------------------------------- 225
            ..|....:.|:...||
  Fly   230 GDPAQHLSHLSHLSHQQHHPHLHHPMHDERSRSPLMLQQLGGNGGNNNNNNNNSSSASNNNNNNN 294

Human   226 -------------------------GSILL--------------------------DKDG----- 234
                                     |::||                          |.||
  Fly   295 NSASANSNIISGNSSSSNNNNGSGNGNMLLGGPGSSISGDQASTIDDSDSDDCGGKDDDGDDSMK 359

Human   235 -------------------KRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQV 280
                               |::..|..|:..|:..|||:||:.|||:..:|..||..|.:::.||
  Fly   360 NGSSANGDSSSHLSLSLSKKQRKARTAFTDHQLQTLEKSFERQKYLSVQDRMELANKLELSDCQV 424

Human   281 KVWFQNRRTKWRKKHAAEM-ATAKKKQDSETERLKGAS 317
            |.|:|||||||:::.|..: ..|:....:..:||.|.:
  Fly   425 KTWYQNRRTKWKRQTAVGLELLAEAGNYAAFQRLYGGA 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NKX6-1	NP_006159.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..133		19/89 (21%)
		Repressor domain. /evidence=ECO:0000250	102..268		68/386 (18%)
		Homeodomain	235..293	CDD:459649	27/57 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	294..367		5/25 (20%)
		Involved in DNA-binding. /evidence=ECO:0000250	306..367		3/12 (25%)
B-H2	NP_523386.1	Homeodomain	381..437	CDD:459649	26/55 (47%)