DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DNaseII and Dnase2b

DIOPT Version :9

Sequence 1:	NP_650672.1	Gene:	DNaseII / 48228	FlyBaseID:	FBgn0000477	Length:	366	Species:	Drosophila melanogaster
Sequence 2:	NP_064341.3	Gene:	Dnase2b / 56629	MGIID:	1913283	Length:	354	Species:	Mus musculus

Alignment Length:	345	Identity:	107/345 - (31%)
Similarity:	160/345 - (46%)	Gaps:	20/345 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 KVSCKDEAGNDVDWWHLYKLPKHYQHNDLGKDTSGLKYLYVTSQNYDTWQMSGKFISDPLSLPAQ 86
            ::||::|.|..|||:..|||||   ......:.:||:|||:.|.. .||..|...|:...|...:
Mouse    25 EISCRNEYGEAVDWFIFYKLPK---RTSKASEEAGLQYLYLDSTR-QTWNKSLYLINSTRSALGR 85

  Fly    87 TLNPLND---DPSHTLLAAYNDQQPNGTVFS-SGGHAKGVVASDGETAIWIVHSVPKFPTIPDYS 147
            ||..|.|   ..:.|....|||..|....:| ..|||||::..:.....|::|||||||.:..|.
Mouse    86 TLQHLYDTHNSTNDTAYLIYNDGVPGSVNYSRQYGHAKGLLVWNRTQGFWLIHSVPKFPPVHGYE 150

  Fly   148 YPTSGEQYAQSMLCVTLKGEDLEKVGQILVYNEPHFYYQRNPLATRSDELFPSLERALHGQWRTE 212
            |||||.:|.|:.:|:|......|::...|:..:|:.|....|.......::  :.|........:
Mouse   151 YPTSGRRYGQTGICITFGYSQFEEIDFQLLVLQPNIYSCFIPSTFHWKLIY--MPRMCANSSSLK 213

  Fly   213 SPFQKDLEVRSLDGKKFRLFGKSGRANVELYADVVAPTLDVSLFVEAWRDGAGNLPNSCDKSDKV 277
            .|.:...|:.|..|..|..|.||.....:::...:|..|...|..:.|:.....||::|.....|
Mouse   214 IPVRYLAELHSAQGLNFVHFAKSSFYTDDIFTGWIAQKLKTHLLAQTWQKKKQELPSNCSLPYHV 278

  Fly   278 LNVESISNPELSVDFKTTQDHSKWAVSRPTGILIYHWRVGGGDWICVGDINRQEGQLHRGGGTVC 342
            .|::||.....|. |.:.||||||.||         .:.....|.|:||:||...|..||||.:|
Mouse   279 YNIKSIGVTSKSY-FSSRQDHSKWCVS---------IKGSANRWTCIGDLNRSLHQALRGGGFIC 333

  Fly   343 HKSARVSNLYRQLVTNYDKC 362
            .|:..:...:.:|...|..|
Mouse   334 TKNHYIYQAFHKLYLRYGFC 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNaseII	NP_650672.1	PLDc_DNaseII_1	21..164	CDD:197219	55/145 (38%)
		DNase_II	24..360	CDD:281283	105/339 (31%)
		PLDc_DNaseII_2	213..362	CDD:197220	44/148 (30%)
Dnase2b	NP_064341.3	DNase_II	29..342	CDD:367426	102/328 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842310
Domainoid	1	1.000	186	1.000	Domainoid score	I3342
eggNOG	1	0.900	-	-		E1_KOG3825
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1052
Inparanoid	1	1.050	187	1.000	Inparanoid score	I3901
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54389
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002558
OrthoInspector	1	1.000	-	-		otm43658
orthoMCL	1	0.900	-	-		OOG6_104320
Panther	1	1.100	-	-	O	PTHR10858
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2694
SonicParanoid	1	1.000	-	-		X1683
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790