Protein Alignment NINJ1 and NijA

DIOPT Version :10

• Sequence 1: NP_004139.2
• Gene: NINJ1 / 4814
• HGNCID: 7824
• Length: 152
• Species: Homo sapiens
• Sequence 2: NP_996040.1
• Gene: NijA / 39215
• FlyBaseID: FBgn0036101
• Length: 245
• Species: Drosophila melanogaster
• Alignment Length: 154
• Identity: 53/154 - (34%)
• Similarity: 80/154 - (51%)
• Gaps: 25/154 - (16%)

Human    11 NGGLPP--GTPGSPDASPARWGWRHGP----IN--------VNHYASKKSAAESMLDIALLMANA 61
            |||..|  ..||           .:||    ||        ||.|..||:.|:.|:|:|||.|||
  Fly    99 NGGRRPSFSFPG-----------YNGPGFVTINGVETPIPDVNAYQHKKTLAQGMMDLALLSANA 152

Human    62 SQLKAVVEQGPSFAFYVPLVVLISISLVLQIGVGVLLIFLVKYDLNNPAKHAKLDFLNNLATGLV 126
            :||:.|:|......::.|.::.||:|::.||.|||.||...:|::.|.....:.:.:||.....:
  Fly   153 NQLRYVLETSSQHPYFYPSLLFISLSIIFQIAVGVGLILNGQYNIKNGHDICRANRINNYTVSGI 217

Human   127 FIIVVVNIFITAFGVQKPLMDMAP 150
            ||:.|||:.|:||.|.:..:...|
  Fly   218 FIVTVVNVLISAFTVDRDTVPALP 241

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NINJ1	NP_004139.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26		6/16 (38%)
		N-terminal adhesion motif. /evidence=ECO:0000269|PubMed:33028854	26..37		2/14 (14%)
		Ninjurin	38..139	CDD:461482	39/100 (39%)
		Required to induce plasma membrane rupture. /evidence=ECO:0000250|UniProtKB:O70131	40..69		15/28 (54%)
		Helix alpha1. /evidence=ECO:0000269|PubMed:37198476, ECO:0000269|PubMed:39667936, ECO:0007744|PDB:8SZA	44..55		5/10 (50%)
		Helix alpha2. /evidence=ECO:0000269|PubMed:37198476, ECO:0000269|PubMed:39667936, ECO:0007744|PDB:8SZA	58..74		7/15 (47%)
NijA	NP_996040.1	Ninjurin	129..230	CDD:461482	39/100 (39%)