DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NID1 and nid-1

DIOPT Version :9

Sequence 1:NP_002499.2 Gene:NID1 / 4811 HGNCID:7821 Length:1247 Species:Homo sapiens
Sequence 2:NP_001256465.1 Gene:nid-1 / 179770 WormBaseID:WBGene00003738 Length:1584 Species:Caenorhabditis elegans


Alignment Length:1682 Identity:396/1682 - (23%)
Similarity:610/1682 - (36%) Gaps:565/1682 - (33%)


- Green bases have known domain annotations that are detailed below.


Human    16 LLLPLLLAGPVGCLSRQELFPFGPGQGDLELEDGDDFVSPALELSGALRFYDRSDIDAVYVTTNG 80
            ||:....|.|.       .:|:|...||..|:...:  ..|:.|...|.:.::| :|.::::.||
 Worm    14 LLIETTTANPA-------FYPYGQPAGDNRLDYSME--QSAIALKIPLTYMEQS-VDELFLSHNG 68

Human    81 IIATSEPPAKESHPGLFPPTFGAVAPFLADLDTTDGLGKVYYR-----EDLSPSITQRAAECVHR 140
            |:...: |..|...||...:..|:|.|...:.:    |.:.||     :.|...:||.    |.:
 Worm    69 IVGLGK-PTPEKIGGLMTISTPAIAVFYVPVTS----GVIDYRVSSDDQGLLTKLTQD----VKQ 124

Human   141 GFPE-ISFQPSSAVVVTWESV--APYQGPSRDPDQKGKRNTFQAVLASSDSSSYAIFLYPEDGLQ 202
            .|.: :.|....||::||..:  |...||:          :||..:.|...|:||||.|      
 Worm   125 VFADAVEFHGLQAVIITWTQIENAEKDGPA----------SFQLAIVSDGISTYAIFRY------ 173

Human   203 FHTTFSKKENNQVPAVVAFSQGSVGFLWKSNGAYNIFANDRESVENLAKSSNSGQQGV------- 260
                      ..:|             |.|:..|...|....|:..:..:.|||...|       
 Worm   174 ----------ESLP-------------WSSSMGYYAQAGFVRSIGKIQTNVNSGGPDVKELVNLS 215

Human   261 -------WVFEIGSPATTNGVVPADVILGTEDGAEYDDEDEDY------DLATTRLGLEDVGTTP 312
                   ::|.:...|..:   |.|.  |.:| .:|::.|::|      |....:.    |...|
 Worm   216 NNQFGNFFIFRVSGSAIED---PKDE--GADD-YDYNNYDQEYEGEHPADCPKDKF----VDNCP 270

Human   313 FSYKALR--RGGADTYSVPSVLSPRRAATERPLGP--PTERTRSFQLAV---------------- 357
            ...:.:|  ||           ..|....|||..|  |.|.....:..|                
 Worm   271 AECRTVRDERG-----------CERCICAERPHAPRAPQEPRPELENTVEDDEDDEQVDGTRYEE 324

Human   358 ------ETFHQQHPQVIDVDEVEETGVVFSYNTDSRQTCA-NNRHQCSVHAECRDYATGFCCSCV 415
                  |..||||.|   .|:.::........:..:.:|: .:...|..::.|:|:..||||:|.
 Worm   325 PARQAQEQHHQQHHQ---PDQPQQQPQRSQEGSLPKMSCSQRDDKSCHANSVCQDFEGGFCCNCD 386

Human   416 AGYTGNGRQCVAEGSPQRVNGKVKGRIFVGSSQVPIVFENTDLHSYVVMNHGRSYTAISTIPETV 480
            .|:.|||::|:.:|.|||::|..:|.|    :::||  :.|:||::.....|..:||:|.||..:
 Worm   387 TGFYGNGKECLPKGEPQRISGSFEGVI----NRIPI--DKTELHTFATSTDGNVHTAVSKIPSDL 445

Human   481 GYSLLPLAPVGGIIGWMFA-VEQDGFKNGFSITGGEFTRQAEVTFVGHPGNLVIKQRFSGIDEHG 544
            |:.|..|..:||::||:|| |:.....|||.:|||.|.|...: .:.....:.|||.|||.:.|.
 Worm   446 GHPLRFLYSIGGVMGWLFADVQSPNVYNGFQLTGGLFNRTVAL-HIEQNYYVTIKQEFSGRNIHD 509

Human   545 HLTIDTELEGRVPQIPFGSSVHIEPYTELY-HYSTSVITSSSTREYTVTEPERDGASPSRIYTYQ 608
            :......:.|.:|.|..||.|....|.|.| ......:||.:..:..|    |||.:   :.||:
 Worm   510 YFKSHLFVSGTLPDIAPGSEVIFPDYEEEYVRERRGYLTSKAAFDVIV----RDGGN---VQTYR 567

Human   609 WR--QTITFQECVHDD-SRPALPSTQQLSVDSVFVLYNQEEKILRYALSN----SIGPV------ 660
            ..  |.|||:||.:.: .|   ..:.:|.|..:.|:||.:|.::||...|    |:||.      
 Worm   568 MSVDQQITFEECPNKEFDR---DHSMKLHVKRINVVYNDDEGVVRYGAKNFATRSVGPAVSAPSG 629

Human   661 ------REGSPD-ALQNPCYI--GTHGCDTNAACRPGPRTQFT--------------CECSIGFR 702
                  :.|..: |.:.|..|  .:....|::.|.|| |.|.|              |||..|::
 Worm   630 GHFDRRQHGQSNMASERPIEIPSQSESISTDSVCAPG-RHQCTLPNMKCRVVDPSYRCECEPGYQ 693

Human   703 GD-------GRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQ----------------- 743
            ..       |..|.|:|||......|..|..|.|.||:|.|:|::|||                 
 Worm   694 AAHDASSHIGWICQDLDECQRGDHNCDQHAKCTNRPGSFSCQCLQGYQGDGRSCIREHQASHHEH 758

Human   744 ------------FSDEGTCVA-----------VVDQRP--------------INYC---ETGL-- 766
                        .:.||.|.|           ...:.|              :|:|   |..:  
 Worm   759 NQQTPQEMAGVGATTEGFCTAHNQCHQWGECVFTSEHPTGRCKCRGWYVGDGVNHCGPPEENMPK 823

Human   767 HNCDIPQR--------------------------------------------------------- 774
            ||.:||||                                                         
 Worm   824 HNANIPQRGGQACGSYVCDVNAECMPEPSGGSECVCKAGFSGNGVTCESLLDDRHAHSSHNRHEQ 888

Human   775 ----------------------------------------------------------------- 774
                                                                             
 Worm   889 QQQTGSLGKVCRSHDECSEHGSCAYHHSLGYYQCACTEPYVGNGVECTLPGSSASAPELGCDVTR 953

Human   775 -----AQCIY---TGGSSYTCSCLPGFSGDGQACQ-----------------------DVDECQP 808
                 |.|:|   :.|:::.|.|..|::|||:.|.                       ....|.|
 Worm   954 DCSEFADCVYERSSTGATFRCVCQSGYTGDGKYCMQSQLAISAISPSVPQLPSEPAVLSTASCNP 1018

Human   809 SRCHPDAFC----YNTPGSFTCQCKPGYQGDGFRCVPGE------------VEKTRCQHEREHIL 857
            : |.|||.|    :|.  .:.|:|...:.|||:.|||..            ||.:.|......::
 Worm  1019 N-CGPDAQCVYDDHNR--QYRCECYAAFMGDGYNCVPLAKPNMVPAQPKTCVESSDCHINGHCVI 1080

Human   858 GAAGA---------------------TDPQRPIPPGLFVPECDAHGH------------------ 883
            ...||                     .|...|..|.    .|..:.|                  
 Worm  1081 NEHGAGEYICQCLPGFSGDGFINCRGADQCNPSNPS----ACYQNAHCVYDAILNAHACKCVDGF 1141

Human   884 ---------YAP--------------TQC--HGSTGYCWCVDRDGREVEG-TRTRPGMTPPCLST 922
                     |||              .||  |..|....|:.:.|...:| |:.....||.|.:.
 Worm  1142 KGDGTSCVPYAPATNCNLEPRICHANAQCVMHHDTNAYECICKPGSSGDGYTKCDVIETPRCTNC 1206

Human   923 VAPPIHQGPAV-PTA------------------------------------VIPLPPGTHLLFAQ 950
               .||...|. ||:                                    .:|...|.::....
 Worm  1207 ---SIHAYCAQNPTSGAYQCKCNAGYNGNGHLCVSMSSCLDDRSLCDENADCVPGEAGHYVCNCH 1268

Human   951 TG--------------KIERLPL-------EGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYW 994
            .|              :.::|.:       |.:|......|..:.:|..:.:|:.|||.::.:.|
 Worm  1269 YGYHGDGRSCSPESSTRSDKLLVARGMAIFERSTNPDEYGKQLIVIPHHIPVGIDFDCKEEKIVW 1333

Human   995 TDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLF 1059
            :|::..||..:||:|.|..:...::|.||||||||...||:::.||..|.|.||.|:|..::.|.
 Worm  1334 SDMSGHSIRTSSLNGTEHKSYFNKELSSPEGIAVDWSSRNVYYADSMNDEIGVASLNGKFKKSLV 1398

Human  1060 ETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLC 1124
            ...|||||.:|.|....:||::||:|:||.|....|||.|.|:.:.:|:.||||||......:||
 Worm  1399 TEGLVNPRSVVLDLYGRHLYYSDWHRENPYIGRVDMDGKNNRVFLNEDVHLPNGLTILPNRRELC 1463

Human  1125 WVDAGTNRAECLNPSQPSRRKALEGLQYPFAVT-SYGKNLYFTDWKMNSVVALDLAISKETDAFQ 1188
            |||||.:|..|:..:...||.....|||||.:| ...:..|:||||.|.:.::.: ..:...:||
 Worm  1464 WVDAGNHRLSCIQYNGAGRRTVFSSLQYPFGLTHDEEQKFYWTDWKDNRIHSVGV-YGEGYRSFQ 1527

Human  1189 PH--KQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLGVDC 1243
            ..  ...:::||......|......||.:||||.||||.......|.||||.....|
 Worm  1528 ISLGGSGKVFGILAVPKSCVGPSTPCSEDNGGCQHLCLPGQNGAVCECPDNVKVKGC 1584

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NID1NP_002499.2 NIDO 106..269 CDD:214712 37/184 (20%)
EGF_3 390..425 CDD:289699 13/35 (37%)
nidG2 429..660 CDD:238158 78/239 (33%)
EGF_3 672..708 CDD:289699 13/58 (22%)
Cell attachment site 702..704 0/1 (0%)
EGF_CA 710..751 CDD:214542 18/69 (26%)
EGF_3 762..800 CDD:289699 18/172 (10%)
EGF_3 811..839 CDD:289699 11/31 (35%)
Thyroglobulin_1 849..919 CDD:278514 21/134 (16%)
LDL-receptor class B 1 990..1032 17/41 (41%)
Ldl_recept_b 992..1029 CDD:278487 15/36 (42%)
LY 1014..1055 CDD:214531 19/40 (48%)
LDL-receptor class B 2 1033..1075 18/41 (44%)
LY 1056..1100 CDD:214531 19/43 (44%)
LDL-receptor class B 3 1076..1120 20/43 (47%)
LY 1101..1137 CDD:214531 17/35 (49%)
LDL-receptor class B 4 1121..1162 17/41 (41%)
FXa_inhibition 1212..>1236 CDD:291342 12/23 (52%)
nid-1NP_001256465.1 NIDO 93..232 CDD:214712 37/185 (20%)
G2F 398..629 CDD:214774 79/247 (32%)
EGF_3 712..747 CDD:289699 13/34 (38%)
EGF_3 841..870 CDD:289699 0/28 (0%)
EGF_CA 954..987 CDD:304395 10/32 (31%)
EGF_CA 1205..1236 CDD:304395 5/33 (15%)
EGF_3 1242..1278 CDD:289699 3/35 (9%)
NHL <1319..1513 CDD:302697 82/193 (42%)
NHL repeat 1319..1354 CDD:271320 12/34 (35%)
NHL repeat 1362..1399 CDD:271320 18/36 (50%)
NHL repeat 1402..1445 CDD:271320 20/42 (48%)
NHL repeat 1450..1482 CDD:271320 14/31 (45%)
NHL repeat 1490..1513 CDD:271320 11/22 (50%)
FXa_inhibition 1553..>1580 CDD:291342 15/26 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 96 1.000 Domainoid score I5069
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 388 1.000 Inparanoid score I1289
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46639
OrthoDB 1 1.010 - - D58517at33208
OrthoFinder 1 1.000 - - FOG0002321
OrthoInspector 1 1.000 - - otm16039
orthoMCL 1 0.900 - - OOG6_104883
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4861
SonicParanoid 1 1.000 - - X2373
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1211.910

Return to query results.
Submit another query.