DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(z)12 and NPL6

DIOPT Version :9

Sequence 1:	NP_730465.1	Gene:	Su(z)12 / 48071	FlyBaseID:	FBgn0020887	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	NP_013809.1	Gene:	NPL6 / 855116	SGDID:	S000004697	Length:	435	Species:	Saccharomyces cerevisiae

Alignment Length:	533	Identity:	90/533 - (16%)
Similarity:	150/533 - (28%)	Gaps:	217/533 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 ERMSRNNKKRISFQVNSMLESITQKSEAVSQNYLHVIYDSLHEKLPARLDNESGEDLLQEQLLCE 156
            |:.||:...|.::.:::....|.:..|....:|               .:.|:.|.:.:|::..|
Yeast    15 EKRSRSTSNRPNYAIDTEDLDIDENDENEDDDY---------------REEEANEGVNEEEISDE 64

  Fly   157 AGESVSVETTLYKITRSKRK--DSTLDFQE--------LLSKCSQIVYNPKDRVGEHATISIPLQ 211
                   |..:.|..|:||:  |...|..|        ..||..:.|:...|...|:      |.
Yeast    65 -------EEQINKSGRNKRRHVDEEEDLSEDKGVTRSRNRSKFKKPVFPGIDDAEEN------LN 116

  Fly   212 TMRPMGEQHTLYKLLFRIKVLSPSTCNDENAETPPNKRSRPNEKMFGSELILYEKSSGFITEGEY 276
            .::.:.|::.|           |   :|...||   |.:...:.:.|.|.::  ::.....:|..
Yeast   117 PLKVVNEEYVL-----------P---DDPEGET---KITADGDLLGGREFLV--RTFTLTEKGNR 162

  Fly   277 EAML--QPLNSTSIKSFSPKKCTWETMPDSYIPLSLTYDVYQQSPMLKFHLTLSNEQLPEMISAP 339
            :.||  :|......:             |||:       .:|..|.| :...|:..|..::|...
Yeast   163 KFMLATEPARIVGFR-------------DSYL-------FFQTHPNL-YKFILNQTQKNDLIDRG 206

  Fly   340 ELQRYVQHLDAVAEMNYNNNNYNNNNNCSGLKNGSG-----------GGNSTVCKTTPEHIQIVY 393
            .|.                  |:..|....|....|           ||         :||...|
Yeast   207 VLP------------------YSYRNRQIALVTARGVFKEFGAKIIRGG---------KHITDDY 244

  Fly   394 NFMYSNNTRQQTEYTQELNCPWCGLDCLRLYALLKHLKLCHARFNFTYQPAGSGARIDVTINDAY 458
                         |..||.                                        |..:..
Yeast   245 -------------YASELR----------------------------------------TKGNVI 256

  Fly   459 DGSYAGSPYDLAGPSGSSFARTCGPVRRTSVTSLMVCRPRRQKTCLDEFLE------LDEDEISN 517
            :|..||.|.|   .|..:......|.....:      .|.:.:.   ||.|      :....|..
Yeast   257 EGKLAGDPID---KSARALETMMYPASENGI------NPAKNQV---EFFEHRPHGHMSNSNIIA 309

  Fly   518 QRSYITGHNRLYHHTETCLPVHP-------KELDIDSEGESDPL-----------------WLRQ 558
            ..|.::..|.||.|:..|...:.       |.|.:|.:|..|..                 |.|.
Yeast   310 SGSKLSSTNWLYQHSAACSRFNSDLFYDRVKVLLVDQQGLRDAYTNILHIPESTQSTTVLGWRRS 374

  Fly   559 KTIQMIDEFSDVN 571
            |.    |..||.:
Yeast   375 KN----DSPSDTS 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(z)12	NP_730465.1	VEFS-Box	511..644	CDD:286776	18/85 (21%)
NPL6	NP_013809.1	CRC_subunit	121..253	CDD:400790	36/251 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345196
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22597
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030