Protein Alignment Su(z)12 and suz12a

DIOPT Version :10

• Sequence 1: NP_730465.1
• Gene: Su(z)12 / 48071
• FlyBaseID: FBgn0020887
• Length: 900
• Species: Drosophila melanogaster
• Sequence 2: NP_001003529.1
• Gene: suz12a / 794171
• ZFINID: ZDB-GENE-040801-36
• Length: 657
• Species: Danio rerio
• Alignment Length: 695
• Identity: 266/695 - (38%)
• Similarity: 395/695 - (56%)
• Gaps: 81/695 - (11%)

  Fly     1 MAPAKKREKDSNPDGSAANGIIGLTHGAPDASNAG----STVPPTAEGQVKLNGHQQEQELFLQA 61
            |||.|        .||..||..|  :.|..|:|.|    |.|..|:..::|:...|.:.:|||:|
Zfish     1 MAPQK--------HGSGGNGFYG--NSASKAANGGAHASSGVVMTSVKRLKMEQIQADHQLFLEA 55

  Fly    62 FEKPTQIYRYLRNRHETNPIFLNRTLSYMKERMSRNNKKRISFQVNSMLESITQKSEAVSQNY-- 124
            |||||||||:||.|:...||||:|:|:||..|.||.|.||.||.:|.:|..: :||:...:::
Zfish    56 FEKPTQIYRFLRTRNLITPIFLHRSLTYMSHRNSRTNSKRKSFSLNDLLFKV-EKSKVDPESHNL 119

  Fly   125 ---LHVIYDSLHEKLPARLDNESGEDLLQEQLLCEAGESVSVETTLYKITRSKRKDSTLDFQELL 186
               |.:.:.....|...:|.|...|:           .|||||..|.|:...||||.|...:::.
Zfish   120 ASNLQLTFTGFFHKTEKQLQNSENEE-----------NSVSVEVLLVKLCHKKRKDVTCPVKQVP 173

  Fly   187 SKCSQIVYNP---KDRVGEHATISIPLQTMRPMGEQHTL--YKLLFRI-----KVLSPSTCNDEN 241
            :...|:..||   ..::|...|:.:|.....|: ..:|:  |.||||.     :..:..|..|.|
Zfish   174 TGKKQVPLNPDISPTKLGAFPTLVVPSHEFEPV-NSNTVKSYSLLFRASRPWGREHNGMTTRDTN 237

  Fly   242 A-ETPPNKRSR------PNEKMFGSELILYEKSSGF-ITEGEYEAMLQPLNSTSIKSFSPKKCTW 298
            . |...|::.|      ..|..|.:::.:::|:... :.:||||..:|.:..:.:   ..|:.||
Zfish   238 VIEELSNRKKRYCSHQDDGETTFVAQMTVFDKNRRLQLLDGEYEVSMQEIEESPV---GKKRATW 299

  Fly   299 ETMPD-SYIPLSLTYDVYQQSPMLKFHLTLSNEQLPEMISAPELQRYVQHLDAVAEMNYNNNNYN 362
            ||:.| .::|   .::.:.|.|.|:|.|..:|: ..:..:||..:       .:|..|..::..:
Zfish   300 ETILDEKWVP---PFETFSQGPTLQFTLRWTND-TADKATAPVAK-------PLATRNSESSTVD 353

  Fly   363 NNNNCSGLK-------NGSGGGNSTVCKTTPEHIQ------IVYNFMYSNNTRQQTEYTQELNCP 414
            ::.. |.:|       |.|.|.:..| :....||:      :.|.|:|:||||||||...:|:||
Zfish   354 SSKT-SNIKPPQAVAVNDSLGTDLPV-RREQTHIEPCQKLHVYYQFLYNNNTRQQTEARDDLHCP 416

  Fly   415 WCGLDCLRLYALLKHLKLCHARFNFTYQPAGSGARIDVTINDAYDGSYAGSPYDLAGPSGSSFAR 479
            ||.|:|.:||:|||||||.|:||.|.|.|...||||||:||:.|||||.|:|.|:....|.:|:|
Zfish   417 WCTLNCRKLYSLLKHLKLSHSRFIFNYVPHPKGARIDVSINECYDGSYVGNPQDILCQPGFAFSR 481

  Fly   480 TCGPVRRTSVTSLMVCRPRRQKTCLDEFLELDEDEISNQRSYITGHNRLYHHTETCLPVHPKELD 544
            . |||:||.||.::||||:|.|..|.||||.::.|...||:||:||||||.|:::|.|:.|:|::
Zfish   482 N-GPVKRTPVTQILVCRPKRSKPSLSEFLEPEDGEQEQQRTYISGHNRLYFHSDSCTPLRPQEME 545

  Fly   545 IDSEGESDPLWLRQKTIQMIDEFSDVNEGEKELMKLWNLHVMRHGFVGDCQLPIACEMFLDAKGT 609
            :|||.|.||.|||:||...|:||:||||||||:||||||.||:|||:.|.|:..||..|::..||
Zfish   546 VDSEDERDPDWLREKTAMQIEEFTDVNEGEKEIMKLWNLLVMKHGFIADNQMNQACMSFVEQHGT 610

  Fly   610 EIVRKNLYRNFILHMCSLFDYGLIAAETVYKTVQKLQGLLSKYAA 654
            .:|.|||.||.:||:.::.|:|||...|:.|.:..|:.|..:..|
Zfish   611 IMVEKNLCRNALLHLINMHDFGLITTATIDKAMTHLRDLTQQSIA 655

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(z)12	NP_730465.1	ZnB-Zn_SUZ12-like	54..>82	CDD:459250	17/27 (63%)
		C2_II_SUZ12	154..328	CDD:467848	51/192 (27%)
		ZnB-Zn_SUZ12	<388..459	CDD:439246	43/76 (57%)
		VEFS-Box	511..644	CDD:462864	70/132 (53%)
suz12a	NP_001003529.1	ZnB-Zn_SUZ12-like	48..>76	CDD:459250	17/27 (63%)
		C2_II_SUZ12	121..327	CDD:467848	56/223 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	335..363		6/35 (17%)
		ZnB-Zn_SUZ12	<389..461	CDD:439246	41/71 (58%)
		VEFS-Box	511..645	CDD:462864	70/133 (53%)
		VEFS-box	528..604		45/75 (60%)